CAJ | 학술논문

目的：探讨不同剂量阿托伐他汀对老年脑梗死患者临床预后的影响。方法：选取2012年2月-2013年10月在我院住院治疗的老年脑梗死患者114例，按随机数字表法分为大剂量组（n=64）和低剂量组（n=50），大剂量组和低剂量组患者在常规治疗的基础上分别加用阿托伐他汀40 mg/d 和10 mg/d 口服治疗。结果：治疗后第3个月，两组患者 NIHSS 评分均明显降低，Barthel 指数明显升高（P ＜0.05），但组间差异无显著性（P ＞0.05）；治疗后第12个月，两组患者稳定性斑块积分均明显升高，不稳定性斑块积分均明显降低，且组间差异具有统计学意义（P ＜0.05）；大剂量组患者治疗后1年内复发率为9.38%，低剂量组患者为16.00%，差异具有统计学意义（P ＜0.05）。结论：大剂量阿托伐他汀可有效改善动脉粥样硬化斑块的稳定性，减少脑梗死的复发。
목적：탐토불동제량아탁벌타정대노년뇌경사환자림상예후적영향。방법：선취2012년2월-2013년10월재아원주원치료적노년뇌경사환자114례，안수궤수자표법분위대제량조（n=64）화저제량조（n=50），대제량조화저제량조환자재상규치료적기출상분별가용아탁벌타정40 mg/d 화10 mg/d 구복치료。결과：치료후제3개월，량조환자 NIHSS 평분균명현강저，Barthel 지수명현승고（P ＜0.05），단조간차이무현저성（P ＞0.05）；치료후제12개월，량조환자은정성반괴적분균명현승고，불은정성반괴적분균명현강저，차조간차이구유통계학의의（P ＜0.05）；대제량조환자치료후1년내복발솔위9.38%，저제량조환자위16.00%，차이구유통계학의의（P ＜0.05）。결론：대제량아탁벌타정가유효개선동맥죽양경화반괴적은정성，감소뇌경사적복발。
Objective: To discuss the effect of different dosage of atorvastatins on the clinical outcomes of elderly patients with cerebral infarction. Methods: One hundred and fourteen cases of elderly patients with cerebral infarction were selected and divided into a large dose group (n=64) and a low dose group (n=50). Patients were treated with atorvastatin 40 mg/d in the large dose group and 10 mg/d in the low dose group on the basis of conventional treatment. Results: The NIHSS scores of both groups were obviously decreased, and Barthel index were obviously increased three months after treatment, however, the differences between two groups showed no statistical significance (P>0.05). The stable plaque scores of both groups were obviously increased, and instability plaque scores were obviously decreased twelfth months after treatment, and the differences between two groups showed statistical significance (P<0.05). The recurrence rate within 1 year was 9.38% in the large dose group and 16% in the low dose group (P<0.05). Conclusion: Atorvastatin at large dosage can effectively improve the stability of atherosclerotic plaque and reduce the recurrence of cerebral infarction.