CAJ | 학술논문

小细胞肺癌的药物治疗仍面临很大的挑战。局限期小细胞肺癌的标准治疗方案为基于铂类药物的化疗方案联合胸部放疗和预防性全脑放疗。对广泛期小细胞肺癌，化疗仍然是主要的治疗方法，必要时还可进行局部放疗。随着新型化疗药物、分子靶向药物和免疫调节剂的不断涌现，小细胞肺癌药物治疗有了更多的实际选择，但治疗结果迄今并未获得实质性的进步，有待今后进一步的深入研究。
소세포폐암적약물치료잉면림흔대적도전。국한기소세포폐암적표준치료방안위기우박류약물적화료방안연합흉부방료화예방성전뇌방료。대엄범기소세포폐암，화료잉연시주요적치료방법，필요시환가진행국부방료。수착신형화료약물、분자파향약물화면역조절제적불단용현，소세포폐암약물치료유료경다적실제선택，단치료결과흘금병미획득실질성적진보，유대금후진일보적심입연구。
Treatment of small cell lung cancer (SCLC) remains a great challenge for oncologists. Generally, limited-stage SCLC can be treated with platinum-based chemotherapy plus concurrent chest radiotherapy and prophylactic cranial irradiation while extensive-stage SCLC can be considered for a platinum-based chemotherapy, and palliative irradiation if needed. Newer chemotherapy agents, molecular-targeted drugs, as well as immunomodulators have provided more choices for SCLC treatment, but no real progress has been made so far, emphasizing the need for a better understanding of the molecular mechanisms and therapeutic targets.