国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
14期
1061-1066
,共6页
王雯%王东%方明明%张兆瑞%张波
王雯%王東%方明明%張兆瑞%張波
왕문%왕동%방명명%장조서%장파
Toll样受体4%基因多态性%结核病%meta分析
Toll樣受體4%基因多態性%結覈病%meta分析
Toll양수체4%기인다태성%결핵병%meta분석
Toll like receptor 4%Polymorphism%Tuberculosis%Meta-analysis
目的 系统评价Toll样受体4(TLR4)基因多态性与结核病易感性的关系.方法 计算机及手工检索自建库至2014年5月发表的关于TLR4基因Asp299Gly和Thr399Ile多态性与结核病易感性的病例-对照研究,提取有关信息,用固定效应模型和随机效应模型进行meta分析,并根据种族进行亚组分析.结果 共纳入7篇文献,病例组2 234例,对照组1 736名.meta分析结果显示:TLR4Asp299Gly多态性与结核病易感性无显著关联性(GvsA:OR =1.04,95％CI:0.79～1.37,P=0.77;GG vs AA:OR =1.56,95％CI:0.76～3.21,P=0.23;GA vs AA:OR=1.01,95％CI:0.84～1.22,P=0.92;GG vs GA+AA:OR=1.55,95％ CI:0.75～3.19,P=0.24;GG+GA vs AA:OR=1.03,95％CI:0.86～1.24,P=0.74).TLR4 Thr399Ile多态性与结核病易感性也无显著联系(TvsC:OR=1.02,95％ CI:0.82～1.27,P=0.86;TT vs CC:OR=1.46,95％ CI:0.62～3.42,P=0.39;TC vsCC:OR =0.97,95％CI:0.76～1.23,P=0.81;TT vs TC+CC:OR =1.43,95％CI:0.61～3.35,P=0.41;TT+TC vs CC:OR =0.99,95％CI:0.79～1.26,P=0.97).并且在亚洲人和非亚洲人中均未见显著相关性.结论 TLR4基因Asp299Gly和Thr399Ile多态性与结核病易感性无关.
目的 繫統評價Toll樣受體4(TLR4)基因多態性與結覈病易感性的關繫.方法 計算機及手工檢索自建庫至2014年5月髮錶的關于TLR4基因Asp299Gly和Thr399Ile多態性與結覈病易感性的病例-對照研究,提取有關信息,用固定效應模型和隨機效應模型進行meta分析,併根據種族進行亞組分析.結果 共納入7篇文獻,病例組2 234例,對照組1 736名.meta分析結果顯示:TLR4Asp299Gly多態性與結覈病易感性無顯著關聯性(GvsA:OR =1.04,95％CI:0.79～1.37,P=0.77;GG vs AA:OR =1.56,95％CI:0.76～3.21,P=0.23;GA vs AA:OR=1.01,95％CI:0.84～1.22,P=0.92;GG vs GA+AA:OR=1.55,95％ CI:0.75～3.19,P=0.24;GG+GA vs AA:OR=1.03,95％CI:0.86～1.24,P=0.74).TLR4 Thr399Ile多態性與結覈病易感性也無顯著聯繫(TvsC:OR=1.02,95％ CI:0.82～1.27,P=0.86;TT vs CC:OR=1.46,95％ CI:0.62～3.42,P=0.39;TC vsCC:OR =0.97,95％CI:0.76～1.23,P=0.81;TT vs TC+CC:OR =1.43,95％CI:0.61～3.35,P=0.41;TT+TC vs CC:OR =0.99,95％CI:0.79～1.26,P=0.97).併且在亞洲人和非亞洲人中均未見顯著相關性.結論 TLR4基因Asp299Gly和Thr399Ile多態性與結覈病易感性無關.
목적 계통평개Toll양수체4(TLR4)기인다태성여결핵병역감성적관계.방법 계산궤급수공검색자건고지2014년5월발표적관우TLR4기인Asp299Gly화Thr399Ile다태성여결핵병역감성적병례-대조연구,제취유관신식,용고정효응모형화수궤효응모형진행meta분석,병근거충족진행아조분석.결과 공납입7편문헌,병례조2 234례,대조조1 736명.meta분석결과현시:TLR4Asp299Gly다태성여결핵병역감성무현저관련성(GvsA:OR =1.04,95％CI:0.79～1.37,P=0.77;GG vs AA:OR =1.56,95％CI:0.76～3.21,P=0.23;GA vs AA:OR=1.01,95％CI:0.84～1.22,P=0.92;GG vs GA+AA:OR=1.55,95％ CI:0.75～3.19,P=0.24;GG+GA vs AA:OR=1.03,95％CI:0.86～1.24,P=0.74).TLR4 Thr399Ile다태성여결핵병역감성야무현저련계(TvsC:OR=1.02,95％ CI:0.82～1.27,P=0.86;TT vs CC:OR=1.46,95％ CI:0.62～3.42,P=0.39;TC vsCC:OR =0.97,95％CI:0.76～1.23,P=0.81;TT vs TC+CC:OR =1.43,95％CI:0.61～3.35,P=0.41;TT+TC vs CC:OR =0.99,95％CI:0.79～1.26,P=0.97).병차재아주인화비아주인중균미견현저상관성.결론 TLR4기인Asp299Gly화Thr399Ile다태성여결핵병역감성무관.
Objective To systematically assess the association between Toll like receptor 4 (TLR4) gene polymorphisms and tuberculosis susceptibility.Methods We systematically searched the electronic Medline,Embase,The Cochrane Library,CNKI,CBMDisc and WanFang databases for research articles about TLR4 gene polymorphisms and tuberculosis up to May 2014.The data were calculated by either fixed-effect model or random-effect model.Results Seven case-control studies were identified,involving 2 234 patients and 1 736 controls.There was no significant association between TLR4 gene Asp299Gly polymorphisms and tuberculosis in the allele model (G vs A:OR =1.04,95 ％ CI:0.79 ～ 1.37,P =0.77),the codominant model (GG vs AA:OR =1.56,95％ CI:0.76～3.21,P =0.23;GA vs AA:OR =1.01,95％ CI:0.84～1.22,P =0.92),the dominant model (GG+GA vs AA:OR =1.03,95％ CI:0.86～1.24,P =0.74),and the recessive model (GG vs GA+ AA:OR =1.55,95％ CI:0.75～3.19,P =0.24).Similarly,there was no significant association between TLR4 gene Thr399Ile polymorphisms and tuberculosis in the allele mode (T vs C:OR =1.02,95％ CI:0.82～1.27,P =0.86),the codominant model (TT vs CC:OR =1.46,95％ CI:0.62～3.42,P =0.39;TC vs CC:OR =0.97,95％ CI:0.76～ 1.23,P =0.81),the dominant mode (TT+TC vs CC:OR =0.99,95％ CI:0.79～1.26,P =0.97),and the recessive mode (TT vs TC+CC:OR =1.43,95％ CI:0.61～3.35,P =0.41).Besides,there were still no significant statistical results in Asian or non-Asian population.Conclusions TLR4 gene Asp299Gly and Thr399Ile polymorphisms are not associated with the susceptibility of tuberculosis.
