CAJ | 학술논문

目的：制备“铁扇癣痒平”喷雾膜剂，对其理化特性和使用效果进行初步评价。方法以泊洛沙姆407为基质，制备“铁扇癣痒平”喷雾膜剂。采用HPLC法测定含量；采用扩散池法测定皮内滞留量；采用家兔皮肤刺激性实验初步评价安全性。结果自制“铁扇癣痒平”喷雾膜剂外观良好；盐酸小檗碱含量91．4±0．6μg? g －1（n＝3）；其12h药物的皮内滞留量是酊剂的3．8倍；无明显皮肤刺激性。结论“铁扇癣痒平”喷雾膜剂制备简单，使用方便，药物皮内滞留量高，且安全无刺激，具有良好的应用前景。
목적：제비“철선선양평”분무막제，대기이화특성화사용효과진행초보평개。방법이박락사모407위기질，제비“철선선양평”분무막제。채용HPLC법측정함량；채용확산지법측정피내체류량；채용가토피부자격성실험초보평개안전성。결과자제“철선선양평”분무막제외관량호；염산소벽감함량91．4±0．6μg? g －1（n＝3）；기12h약물적피내체류량시정제적3．8배；무명현피부자격성。결론“철선선양평”분무막제제비간단，사용방편，약물피내체류량고，차안전무자격，구유량호적응용전경。
OBJECTIVE To prepare and evaluate Tieshan Xuanyangping Spray Film ( TX-SF).METHODS TX-SF was prepared using Poloxamer 407 as matrix.The content of Berberine Hydrochloride was determined by HPLC ,the drug retention in pig skin was investigated using Franz diffusion cell .,while the skin irritation was evalua-ted using Rabbits.RESULTS TX-SF was transparent and uniform .The content of Berberine Hydrochloride was 91.4 ±0.6μg? g-1(n=3).The drug retention of spray film was 2.8 times more than that of tincture.No skin stimu-lus were observed.CONCLUSION TX-SF was easy to prepare ,had high drug retention in skin and no skin irrita-tion.It had good application prospect .