CAJ | 학술논문

目的：探讨降钙素原(PCT)和1，3-β-D葡聚糖(G试验)联合检测诊断ICU危重患者深部真菌感染的价值。方法将我院2012年11月至2014年8月确诊为深部真菌感染的ICU危重患者106例作为真菌组，非深部真菌感染者519例为对照组，分别进行血清PCT和1，3-β-D葡聚糖含量检测，以配对t检验比较结果的差异性。结果真菌组血清中PCT和1，3-β-D葡聚糖含量分别为(0.701±0.22) pg/ml和(37.82±18.43) pg/ml，明显高于对照组的(0.238±0.12) pg/ml和(14.96±4.37) pg/ml，两者结果比较差异均有统计学意义(P<0.05)；真菌组血清中PCT阳性检出率为57.5%(61/106)，明显低于1，3-β-D葡聚糖阳性检出率[89.6%(95/106)]，差异有统计学意义(P<0.05)。结论 ICU深部真菌感染危重患者血清中的PCT和1，3-β-D葡聚糖含量均明显高于ICU非深部真菌感染的危重患者，PCT和1，3-β-D葡聚糖联合检测对ICU危重病患者深部真菌感染诊断有重要的临床意义。
목적：탐토강개소원(PCT)화1，3-β-D포취당(G시험)연합검측진단ICU위중환자심부진균감염적개치。방법장아원2012년11월지2014년8월학진위심부진균감염적ICU위중환자106례작위진균조，비심부진균감염자519례위대조조，분별진행혈청PCT화1，3-β-D포취당함량검측，이배대t검험비교결과적차이성。결과진균조혈청중PCT화1，3-β-D포취당함량분별위(0.701±0.22) pg/ml화(37.82±18.43) pg/ml，명현고우대조조적(0.238±0.12) pg/ml화(14.96±4.37) pg/ml，량자결과비교차이균유통계학의의(P<0.05)；진균조혈청중PCT양성검출솔위57.5%(61/106)，명현저우1，3-β-D포취당양성검출솔[89.6%(95/106)]，차이유통계학의의(P<0.05)。결론 ICU심부진균감염위중환자혈청중적PCT화1，3-β-D포취당함량균명현고우ICU비심부진균감염적위중환자，PCT화1，3-β-D포취당연합검측대ICU위중병환자심부진균감염진단유중요적림상의의。
Objective To explore the diagnostic value of joint detection of procalcitonin (PCT) and 1,3-beta D-glucan (G test) in critical patients with deep fungus infection in ICU. Methods From November 2012 to August 2014, 106 critical patients diagnosed with deep fungal infection in ICU were enrolled as the fungal group, and 519 pa-tients with fungus infection (not deep) were selected as control group. Detection of serum PCT and 1, 3-D beta glucan was performed in both groups, and matching t test was applied to compare the difference of the result. Results The levels of serum PCT and 1, 3-D beta glucan of the fungal group were (0.701 ± 0.22) pg/ml and (37.82 ± 18.43) pg/ml, significantly higher than (0.238±0.12) pg/ml and (14.96±4.37) pg/ml in the control group, with statistically significant differences between the two groups (P<0.05). The positive detection rate of serum PCT was 57.5%(61/106) in the fun-gal group, significantly lower than the positive detection rate of 1, 3-D beta glucan [89.6%(95/106)], with statistically significant difference (P<0.05). Conclusion Critical patients with deep fungal infection in ICU have significantly higher levels of serum PCT and 1, 3-beta-D glucan than the patients with non-deep fungus infection in ICU. Joint de-tection of PCT and 1, 3-beta-D glucan has significant clinical values in the diagnosis of deep fungal infection in criti-cal patients in ICU.