海峡药学
海峽藥學
해협약학
STRAIT PHARMACEUTICAL JOURNAL
2015年
7期
24-27
,共4页
孔晓龙%郭梅红%黄兴振%黄小丹%范颖%黄燕
孔曉龍%郭梅紅%黃興振%黃小丹%範穎%黃燕
공효룡%곽매홍%황흥진%황소단%범영%황연
血脂%虎杖降脂颗粒%高脂血症%血液流变学
血脂%虎杖降脂顆粒%高脂血癥%血液流變學
혈지%호장강지과립%고지혈증%혈액류변학
Blood lipid%HuzhangJiangzhi Granules%Hyperlipidemia%Hemorheology
目的:研究虎杖降脂颗粒对高脂血症大鼠降脂作用的机理。方法高脂性饮食诱导大鼠高脂血症,口服给予不同剂量的虎杖降脂颗粒,考察其对模型动物的SOD、MDA、GSH-Px水平、肝组织脂蛋白酯酶(Lipoprotein Lipase,LPL)、肝酯酶(Hepatic Lipase,HL)和总脂酶活性以及对包括全血粘度、全血还原粘度、全血相对指数、血浆粘度值、红细胞压积(HCT)、红细胞刚性指数(IER)、红细胞聚集指数(IEA)、红细胞变形指数( IED)在内血液流变学性质的影响。结果与模型组比较,血脂康、脂降宁阳性对照组和实验组中、高剂量组 SOD 活性均不同程度升高, MDA活性均不同程度降低,差异均有统计学意义(P<0.01或P<0.05);与模型组比较,血脂康、脂降宁阳性对照组和实验组低、中、高剂量组均能不同程度地升高LPL、HL和总脂酶活性;而且均能不同程度地降低大鼠全血粘度,血浆粘度,全血高、低切还原粘度和全血高、低切相对指数,以及降低HCT、IER和IEA,差异有统计学意义(P<0.01或P<0.05)结论虎杖降脂颗粒对高脂乳剂诱导的高脂血症模型大鼠具有明显的治疗作用,该作用可能与其提高机体的抗氧化能力、抵抗自由基介导的脂质过氧化作用,调节肝脏脂代谢关键酶LPL和HL的活性以及改善血液流变学有关。
目的:研究虎杖降脂顆粒對高脂血癥大鼠降脂作用的機理。方法高脂性飲食誘導大鼠高脂血癥,口服給予不同劑量的虎杖降脂顆粒,攷察其對模型動物的SOD、MDA、GSH-Px水平、肝組織脂蛋白酯酶(Lipoprotein Lipase,LPL)、肝酯酶(Hepatic Lipase,HL)和總脂酶活性以及對包括全血粘度、全血還原粘度、全血相對指數、血漿粘度值、紅細胞壓積(HCT)、紅細胞剛性指數(IER)、紅細胞聚集指數(IEA)、紅細胞變形指數( IED)在內血液流變學性質的影響。結果與模型組比較,血脂康、脂降寧暘性對照組和實驗組中、高劑量組 SOD 活性均不同程度升高, MDA活性均不同程度降低,差異均有統計學意義(P<0.01或P<0.05);與模型組比較,血脂康、脂降寧暘性對照組和實驗組低、中、高劑量組均能不同程度地升高LPL、HL和總脂酶活性;而且均能不同程度地降低大鼠全血粘度,血漿粘度,全血高、低切還原粘度和全血高、低切相對指數,以及降低HCT、IER和IEA,差異有統計學意義(P<0.01或P<0.05)結論虎杖降脂顆粒對高脂乳劑誘導的高脂血癥模型大鼠具有明顯的治療作用,該作用可能與其提高機體的抗氧化能力、牴抗自由基介導的脂質過氧化作用,調節肝髒脂代謝關鍵酶LPL和HL的活性以及改善血液流變學有關。
목적:연구호장강지과립대고지혈증대서강지작용적궤리。방법고지성음식유도대서고지혈증,구복급여불동제량적호장강지과립,고찰기대모형동물적SOD、MDA、GSH-Px수평、간조직지단백지매(Lipoprotein Lipase,LPL)、간지매(Hepatic Lipase,HL)화총지매활성이급대포괄전혈점도、전혈환원점도、전혈상대지수、혈장점도치、홍세포압적(HCT)、홍세포강성지수(IER)、홍세포취집지수(IEA)、홍세포변형지수( IED)재내혈액류변학성질적영향。결과여모형조비교,혈지강、지강저양성대조조화실험조중、고제량조 SOD 활성균불동정도승고, MDA활성균불동정도강저,차이균유통계학의의(P<0.01혹P<0.05);여모형조비교,혈지강、지강저양성대조조화실험조저、중、고제량조균능불동정도지승고LPL、HL화총지매활성;이차균능불동정도지강저대서전혈점도,혈장점도,전혈고、저절환원점도화전혈고、저절상대지수,이급강저HCT、IER화IEA,차이유통계학의의(P<0.01혹P<0.05)결론호장강지과립대고지유제유도적고지혈증모형대서구유명현적치료작용,해작용가능여기제고궤체적항양화능력、저항자유기개도적지질과양화작용,조절간장지대사관건매LPL화HL적활성이급개선혈액류변학유관。
OBJECTIVE To study the mechanism for reducing blood lipids of HuzhangJiangzhi Granules in hy -perlipidemic rats.METHODS The hyperlipidemia was induced by administrating with high fat emulsion ,different oral doses of HuzhangJiangzhi Granules were given to rats .The effect for the drug on SOD,MDA,GSH-Px,enzyme activity of LPL,HL and total lipase,characteristic of hemorheology including whole blood viscosity ,whole blood re-duced viscosity and plasma viscosity ,HCT,ER,IEA,IED were observed.RESULTS The SOD activity were all in-creased to different degrees in positive control group ,middle dose group and high dose group compared with the mod-el group ,the activity of MDA were reduced to varying degrees ,the difference has statistical significance ( P<0.01 ,P<0.05).Likewise,the enzyme activity of LPL,HL and total lipase were all increased to different degrees.The pa-rameters of hemorheology were reduced to arying degrees including whole blood viscosity ,whole blood reduced viscos-ity and plasma viscosity , HCT, ER, IEA, IED.the difference has statistical significance ( P <0.01 , P <0.05 ) .CONCLUSION Huzhang Jiangzhi Granules has significant therapeutic effects for hyperlipidemic rats induced by high-fat emulsion.the effects may be related to improve the body′s antioxidant capacity and resist lipid peroxidation mediated by free radical.regulating enzymes activity of LPL and HL and improve characteristic of hemorheology .