CAJ | 학술논문

目的：检测鼻息肉患者外周血中Th17细胞的表达水平，初步探讨其与鼻息肉形成的关系。方法收集46例慢性鼻窦炎伴鼻息肉患者的外周血作为鼻息肉组，另收22例单纯鼻出血或者鼻中隔偏曲患者外周血作为对照组。采用流式细胞术检测两组患者的外周血中的Th17细胞的表达水平。结果鼻息肉组外周血中Th17细胞的表达水平为(4.03±0.69)%，明显高于对照组的(1.35±0.26)%，差异有显著统计学意义(P<0.05)。结论鼻息肉的发生发展可能与高水平表达Th17细胞存在一定关系，具体发病机制有待进一步研究。
목적：검측비식육환자외주혈중Th17세포적표체수평，초보탐토기여비식육형성적관계。방법수집46례만성비두염반비식육환자적외주혈작위비식육조，령수22례단순비출혈혹자비중격편곡환자외주혈작위대조조。채용류식세포술검측량조환자적외주혈중적Th17세포적표체수평。결과비식육조외주혈중Th17세포적표체수평위(4.03±0.69)%，명현고우대조조적(1.35±0.26)%，차이유현저통계학의의(P<0.05)。결론비식육적발생발전가능여고수평표체Th17세포존재일정관계，구체발병궤제유대진일보연구。
Objective To detect the expression of Th17 cells in peripheral blood in nasal polyps, and to ex-plore the role of Th17 cells in pathogenesis of nasal polyposis. Methods The peripheral blood samples were collect-ed from 46 patients of chronic sinusitis with nasal polyp (CRSwNP, the study group) and 22 patients with simple nasal bleeding or nasal septum deviation (the control group). Flow cytometry was used to detect the expression levels of Th17 cells in peripheral blood in the two groups. Results The levels of Th17 cells in the study group was (4.03%± 0.69%), significantly higher than (1.35%± 0.26%) in the control group (P<0.05). Conclusion The pathogenesis of CRSwNP may be involved in the increased expression of Th17 cells, and the detailed mechanisms should be further studied.