CAJ | 학술논문

目的：探讨HOXA10启动子区基因多态性对体外受精及胚胎移植(IVF-ET)患者子宫内膜容受性的影响。方法将2013年7月至2014年7月在海南省农垦总医院行IVF-ET的不孕患者220例按照妊娠结局分为妊娠成功组(117例)和受孕失败组(103例)，检测两组患者HOXA10基因启动子区SNP位点rs3779456多态性，利用统计学软件SPSS19.0探讨其基因型及等位基因与女性子宫内膜容受性的关联性。结果对TT基因型和(CC+CT)的比较结果及对CC基因型和(TT+CT)的比较结果显示P均<0.05，且TT在受孕并正常发育组和受孕失败组的OR值为1.45。对等位基因T和C的分析显示差异无统计学意义(P>0.05)。结论基因型TT有利于子宫内膜对胎儿的容受性，而CC则反之。
목적：탐토HOXA10계동자구기인다태성대체외수정급배태이식(IVF-ET)환자자궁내막용수성적영향。방법장2013년7월지2014년7월재해남성농은총의원행IVF-ET적불잉환자220례안조임신결국분위임신성공조(117례)화수잉실패조(103례)，검측량조환자HOXA10기인계동자구SNP위점rs3779456다태성，이용통계학연건SPSS19.0탐토기기인형급등위기인여녀성자궁내막용수성적관련성。결과대TT기인형화(CC+CT)적비교결과급대CC기인형화(TT+CT)적비교결과현시P균<0.05，차TT재수잉병정상발육조화수잉실패조적OR치위1.45。대등위기인T화C적분석현시차이무통계학의의(P>0.05)。결론기인형TT유리우자궁내막대태인적용수성，이CC칙반지。
Objective To investigate the effect of polymorphism of the HOXA10 promoter on the endometri-al receptivity of patients who underwent in vitro fertilization-embryo transfer (IVF-ET). Methods Two hundred and twenty infertile patients who underwent IVF-ET from July 2013 to July 2014 in Hainan Provincial Nongken General Hospital were divided into two groups according to pregnancy (117 cases, the success group) or not (103 cases, the failure group). The polymorphism of rs3779456 located in the HOXA10 promoter was detected, and the data were ana-lyzed by SPSS19.0 to investigate the correlation between the genotypes and the endometrial receptivity of patients. Results The difference between TT and (CC+CT) was significant with P<0.05, and the difference between CC and (TT+CT) was significant as well. The OR value of TT frequency in the success group and the failure group was 1.45. There was no significant difference between the frequency of allele T and C (P>0.05). Conclusion TT is beneficial to the endometrial receptivity, while CC may be on the contrary.