CAJ | 학술논문

目的：观察阿立哌唑和利培酮治疗首发精神分裂症的临床疗效。方法选择2011年1月~2013年1月本院收治的85例首发精神分裂症的患者，随机分为两组，对照组患者给予利培酮治疗，观察组给予阿立哌唑治疗，观察两组患者的临床治疗效果及用药后的不良反应情况。结果观察组患者治疗后总有效率为91.30%，对照组治疗后总有效率为92.31%，两组比较，差异无统计学意义(P>0.05)；用药后观察组的不良反应发生率为26.09%，对照组为69.23%，两组比较，差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮治疗首发精神分裂症的临床疗效显著，但阿立哌唑用药后不良反应较少，安全性高，值得临床推广应用。
목적：관찰아립고서화리배동치료수발정신분렬증적림상료효。방법선택2011년1월~2013년1월본원수치적85례수발정신분렬증적환자，수궤분위량조，대조조환자급여리배동치료，관찰조급여아립고서치료，관찰량조환자적림상치료효과급용약후적불량반응정황。결과관찰조환자치료후총유효솔위91.30%，대조조치료후총유효솔위92.31%，량조비교，차이무통계학의의(P>0.05)；용약후관찰조적불량반응발생솔위26.09%，대조조위69.23%，량조비교，차이유통계학의의(P<0.05)。결론아립고서화리배동치료수발정신분렬증적림상료효현저，단아립고서용약후불량반응교소，안전성고，치득림상추엄응용。
Objective To study the clinical effect between aripiprazole and risperidone in the treatment of first-episode schizophrenia. Methods 85 cases of first-episode schizophrenia patients in our hospital from January 2011 to January 2013 were randomly divided into two groups.The control group was treated with risperidone while the observation group was given aripiprazole treatment.Then the clinical effect and drug adverse reaction between two groups was compared respectively. Results After the treatment,the total effective rate of the treatment of observation group was 91.30%.While the total effective rate of control group was 92.31%,with no statistical differenc (P>0.05).The incidence of adverse reac-tions of observation group was 26.09%, while the control group was 69.23%,with statistical difference (P<0.05). Con-clusion The clinical effect of aripiprazole and risperidone in the treatment of first-episode schizophrenia is significant, but the adverse reaction of aripiprazole is smaller and the safety is higher.It is worthy of clinical popularization and ap-plication.