中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
21期
103-105
,共3页
超敏C-反应蛋白%心肌酶%新生儿窒息
超敏C-反應蛋白%心肌酶%新生兒窒息
초민C-반응단백%심기매%신생인질식
High sensitivity C-reactive protein%Myocardial enzyme%Neonatal asphyxia
目的：探讨超敏C-反应蛋白(hs-CRP)、心肌酶测定与新生儿窒息程度的关系。方法选取2012年1月~2014年12月本院收治的123例窒息新生儿，根据出生后1 min内的新生儿Apgar评分，其中42例为重度窒息组，81例为轻度窒息组；选取本院同期顺产分娩的健康无窒息新生儿30例为对照组。3组新生儿在出生24 h内抽静脉血，测定血清中hs-CRP和心肌酶(AST、LDH、CK、CK-MB、α-HBDH)，并作对比分析。结果重度窒息组的hs-CRP和心肌酶指标均高于轻度窒息组，差异有统计学意义(P<0.05)；轻度窒息组的hs-CRP和心肌酶指标均高于对照组，差异有统计学意义(P<0.05)。结论 hs-CRP和心肌酶在窒息新生儿中均显著升高，且升高程度与窒息程度成正相关，可作为心肌损害及严重程度的评估指标。hs-CRP与心肌酶的测定对新生儿窒息所致心肌损害的早期诊断和预后评估有重要的临床价值。
目的：探討超敏C-反應蛋白(hs-CRP)、心肌酶測定與新生兒窒息程度的關繫。方法選取2012年1月~2014年12月本院收治的123例窒息新生兒，根據齣生後1 min內的新生兒Apgar評分，其中42例為重度窒息組，81例為輕度窒息組；選取本院同期順產分娩的健康無窒息新生兒30例為對照組。3組新生兒在齣生24 h內抽靜脈血，測定血清中hs-CRP和心肌酶(AST、LDH、CK、CK-MB、α-HBDH)，併作對比分析。結果重度窒息組的hs-CRP和心肌酶指標均高于輕度窒息組，差異有統計學意義(P<0.05)；輕度窒息組的hs-CRP和心肌酶指標均高于對照組，差異有統計學意義(P<0.05)。結論 hs-CRP和心肌酶在窒息新生兒中均顯著升高，且升高程度與窒息程度成正相關，可作為心肌損害及嚴重程度的評估指標。hs-CRP與心肌酶的測定對新生兒窒息所緻心肌損害的早期診斷和預後評估有重要的臨床價值。
목적：탐토초민C-반응단백(hs-CRP)、심기매측정여신생인질식정도적관계。방법선취2012년1월~2014년12월본원수치적123례질식신생인，근거출생후1 min내적신생인Apgar평분，기중42례위중도질식조，81례위경도질식조；선취본원동기순산분면적건강무질식신생인30례위대조조。3조신생인재출생24 h내추정맥혈，측정혈청중hs-CRP화심기매(AST、LDH、CK、CK-MB、α-HBDH)，병작대비분석。결과중도질식조적hs-CRP화심기매지표균고우경도질식조，차이유통계학의의(P<0.05)；경도질식조적hs-CRP화심기매지표균고우대조조，차이유통계학의의(P<0.05)。결론 hs-CRP화심기매재질식신생인중균현저승고，차승고정도여질식정도성정상관，가작위심기손해급엄중정도적평고지표。hs-CRP여심기매적측정대신생인질식소치심기손해적조기진단화예후평고유중요적림상개치。
Objective To investigate the relevance between the degree of neonatal asphyxia and the determination of high sensitivity C-reactive protein(hs-CRP) and myocardial enzyme. Methods 123 cases of neonatal suffocation admit-ted into our hospital from January 2012 to December 2014 were selected.According to born within 1 min after the neonatal Apgar score,42 cases as severe asphyxia group and 81 cases as mild asphyxia group.30 cases of healthy and without asphyxia newborn baby at the same period in our hospital were selected as control group.Three groups were phlebotomized within 24h after birth to determine serum hs-CRP and myocardial enzyme(AST,LDH,CK,CK-MB,α-HBDH) for comparative analysis. Results The hs-CRP and myocardial enzyme in the severe asphyxia group were higher than those in the mild asphyxia group,the difference was statistically significant(P<0.05).The hs-CRP and myocardial enzyme in the mild asphyxia group were higher than those in the control group,the difference was statistically significant (P<0.05). Conclusion Both hs-CRP and myocardial enzyme were increased in asphyxial newborns.The degrees of elevation are positively correlated with the degrees of asphyxia,which can be used as the indexes of evaluating myocardial dam-age and its severity.The determination of hs-CRP and myocardial enzyme has an important clinical value in the early diagnosis and prognostic evaluation on the myocardial damage caused by neonatal asphyxia.
