中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
21期
67-69,72
,共4页
黄葵胶囊%血管紧张素转化酶抑制剂%血管紧张素域受体拮抗剂%糖尿病肾病
黃葵膠囊%血管緊張素轉化酶抑製劑%血管緊張素域受體拮抗劑%糖尿病腎病
황규효낭%혈관긴장소전화매억제제%혈관긴장소역수체길항제%당뇨병신병
Abelmoschus moschatus Capsule%Angiotensin converting enzyme inhibitors%Angiotensin II receptor an-tagonist%Diabetic nephropathy
目的：观察黄葵胶囊联合ACEI及ARB治疗早期糖尿病肾病(DN)的有效性及安全性。方法选取本科2014年1~7月被诊断为早期DN的患者60例，随机分为两组，每组30例。在控制血糖的基础上，对照组给予依那普利、厄贝沙坦治疗，观察组在对照组基础上加用黄葵胶囊治疗。观察两组治疗后24 h尿蛋白排泄率(UAER)、血肌酐(SCr)、血尿素氮(BUN)、血糖、血压等的变化及用药后不良反应。结果随着治疗时间延长，两组UAER、SCr及BUN水平逐渐下降，观察组UAER、SCr及BUN较对照组低，差异有统计学意义(P<0.05)；观察组血糖和血压各指标水平均低于对照组，差异有统计学意义(P<0.05)；观察组出现2例不良反应，对照组未出现不良反应，差异无统计学意义(P>0.05)。结论黄葵胶囊联合ACEI及ARB治疗早期DN是一种安全、有效的治疗方案。
目的：觀察黃葵膠囊聯閤ACEI及ARB治療早期糖尿病腎病(DN)的有效性及安全性。方法選取本科2014年1~7月被診斷為早期DN的患者60例，隨機分為兩組，每組30例。在控製血糖的基礎上，對照組給予依那普利、阨貝沙坦治療，觀察組在對照組基礎上加用黃葵膠囊治療。觀察兩組治療後24 h尿蛋白排洩率(UAER)、血肌酐(SCr)、血尿素氮(BUN)、血糖、血壓等的變化及用藥後不良反應。結果隨著治療時間延長，兩組UAER、SCr及BUN水平逐漸下降，觀察組UAER、SCr及BUN較對照組低，差異有統計學意義(P<0.05)；觀察組血糖和血壓各指標水平均低于對照組，差異有統計學意義(P<0.05)；觀察組齣現2例不良反應，對照組未齣現不良反應，差異無統計學意義(P>0.05)。結論黃葵膠囊聯閤ACEI及ARB治療早期DN是一種安全、有效的治療方案。
목적：관찰황규효낭연합ACEI급ARB치료조기당뇨병신병(DN)적유효성급안전성。방법선취본과2014년1~7월피진단위조기DN적환자60례，수궤분위량조，매조30례。재공제혈당적기출상，대조조급여의나보리、액패사탄치료，관찰조재대조조기출상가용황규효낭치료。관찰량조치료후24 h뇨단백배설솔(UAER)、혈기항(SCr)、혈뇨소담(BUN)、혈당、혈압등적변화급용약후불량반응。결과수착치료시간연장，량조UAER、SCr급BUN수평축점하강，관찰조UAER、SCr급BUN교대조조저，차이유통계학의의(P<0.05)；관찰조혈당화혈압각지표수평균저우대조조，차이유통계학의의(P<0.05)；관찰조출현2례불량반응，대조조미출현불량반응，차이무통계학의의(P>0.05)。결론황규효낭연합ACEI급ARB치료조기DN시일충안전、유효적치료방안。
Objective To observe the efficacy and safety of Abelmoschus moschatus capsule combined with ACEI and ARB on the urinary albumin excretion rate of early stage diabetic nephropathy (DN). Methods 60 patients with early stage DN were randomly divided into two groups,with 30 cases in each group.Based on treatment of controlling blood glucose,the control group was given enalapril and irbesartan,the observation group was given Abelmoschus moschatus capsule based on the treatment of control group.The urinary protein excretion rate(UAER)of 24 h,serum creatinine(SCr), blood urea nitrogen(BUN) and blood glucose,blood pressure,and adverse reactions between two groups was observed re-spectively after treatment. Results With the treatment time prolonged,UAER,SCr and BUN of observation group was lower than that of control group respectively,with statistical difference (P<0.05).The blood glucose and blood pressure of observation group was lower than that of control group respectively,with statistical difference(P<0.05).There were 2 cas-es in observation group,no case in control group with adverse reactions,with no statistical differenc between two groups (P>0.05). Conclusion Abelmoschus moschatus capsule combined with ACEI and ARB in the treatment of early stage diabetic nephropathy is a safe,effective treatment scheme.
