CAJ | 학술논문

目的探讨立体定向下自体干细胞移植治疗脑出血后遗症的临床效果.方法将2011年1月至2013年9月在我院住院治疗的100例脑出血后遗症患者应用计算机随机分为实验组和对照组,每组50例.实验组患者脑出血后6个月在立体定向下行自体干细胞移植治疗,对照组患者仅行对症治疗.比较两组患者在脑出血7、12个月时神经功能缺损评分和功能独立性测量(FIM)评分.结果实验组和对照组脑出血后7个月FIM评分分别为(102.08±8.28)分与(95.28±8.75)分,神经功能缺损评分分别为(13.12±4.00)分与(20.40±4.33)分,实验组均优于对照组,差异均有统计学意义(P均＜0.05),而脑出血后6个月和12个月时两组间差异并无统计学意义(P均＞0.05).结论立体定向下自体干细胞移植治疗脑出血后遗症的近期疗效有差异、远期疗效无差异.
목적 탐토입체정향하자체간세포이식치료뇌출혈후유증적림상효과.방법 장2011년1월지2013년9월재아원주원치료적100례뇌출혈후유증환자응용계산궤수궤분위실험조화대조조,매조50례.실험조환자뇌출혈후6개월재입체정향하행자체간세포이식치료,대조조환자부행대증치료.비교량조환자재뇌출혈7、12개월시신경공능결손평분화공능독립성측량(FIM)평분.결과 실험조화대조조뇌출혈후7개월FIM평분분별위(102.08±8.28)분여(95.28±8.75)분,신경공능결손평분분별위(13.12±4.00)분여(20.40±4.33)분,실험조균우우대조조,차이균유통계학의의(P균＜0.05),이뇌출혈후6개월화12개월시량조간차이병무통계학의의(P균＞0.05).결론 입체정향하자체간세포이식치료뇌출혈후유증적근기료효유차이、원기료효무차이.
Objective To investigate the therapeutic effect of autologous stem cell transplantation research for patients with cerebral hemorrhage sequelae under the stereotactic.Methods One hundred patients with cerebral hemorrhage from Jan.2011 to Sep.2013 in our hospital were selected and randomly divided into the experimental group (n =50) and the control group (n =50).The patients of experimental group were given autologous stem cell transplantation under the stereotactic in 6 months after cerebral hemorrhage,while the patients in control group were just given traditional treatment.At 6,7 and 12 months after cerebral hemorrhage,rate with neural function defect scale and functional independence measure(FIM) scores of the two groups were compared.Results FIM scores in the experimental group was 102.08 ± 8.28,significant higher than that in control group(95.28±8.75,P＜0.05).Functional independence measure scores in the experimental group at 7 months after cerebral hemorrhage was 13.12±4.00,significant lower than that in control group(20.40±4.33,P ＜0.05).While,there was no statistical difference at 6 months and 12 months after cerebral hemorrhage between the two groups(P＞0.05).Conclusion The therapeutic of autologous stem cell transplantation on patients with cerebral hemorrhage sequelae under the stereotactic is benefit at short term,but the long term therapy effective still needs further study.