中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
5期
404-407
,共4页
王青梅%冯玉宝%李永玲%李长青%乔建晶%郭宏
王青梅%馮玉寶%李永玲%李長青%喬建晶%郭宏
왕청매%풍옥보%리영령%리장청%교건정%곽굉
原发性高血压%季节性变异%8羟基脱氧鸟苷%钙通道阻滞剂%肾素-血管紧张素-醛固酮系统抑制剂
原髮性高血壓%季節性變異%8羥基脫氧鳥苷%鈣通道阻滯劑%腎素-血管緊張素-醛固酮繫統抑製劑
원발성고혈압%계절성변이%8간기탈양조감%개통도조체제%신소-혈관긴장소-철고동계통억제제
Essential hypertension%Season variability%8-hydroxydeoxyguanosine%Ca2+ channel blocker%Renin angiotensin aldosterone system inhibitors
目的 观察两种降压治疗方法对原发性高血压患者血压和尿8羟基脱氧鸟苷(8-OHdG)季节性变异的影响.方法 选择2013年夏季就诊于内蒙古医科大学鄂尔多斯临床医学院心内科门诊的原发性高血压患者50例,8例失访,最终研究对象为42例,按照前瞻性随机对照研究方法分为两组,含肾素-血管紧张素-醛固酮系统抑制剂(RASI)组30例,钙通道阻滞剂(CCB)组12例.Epidata 3.1软件建立数据库,两组均在2013年夏季、秋季、冬季及2014年春季来院,收集无菌尿液,酶联免疫吸附测定法检测尿8-OHdG浓度,观察两组患者春、夏、秋、冬季血压及尿8-OHdG浓度的变化.结果 RASI组与CCB组的收缩压冬季高于夏季[RASI组:(158±20)、(145±12) mmHg,CCB组:(158±20)、(141±9)mmHg],舒张压冬季高于夏季[RASI组:(101±13)、(93±9) mmHg,CCB组:(100±4)、(90±7) mmHg],差异均有统计学意义(P均＜0.05).RASI组尿8-OhdG浓度夏季和秋季高于冬季和春季[夏季:(243.20±30.94) ng/L,秋季:(240.40±47.99) ng/L,冬季:(190.80±15.56) ng/L,春季:(189.06±13.56) ng/L],差异均有统计学意义(P均＜0.001);CCB组春、夏、秋、冬季比较差异均无统计学意义(P均＞0.05).结论 原发性高血压患者经口服CCB以及含RASI为基础治疗药物的降压治疗,血压的季节性变异仍然存在,冬季血压高于夏季;以含有RASI为基础治疗药物的降压治疗,可以使冬季的氧化应激水平明显降低.
目的 觀察兩種降壓治療方法對原髮性高血壓患者血壓和尿8羥基脫氧鳥苷(8-OHdG)季節性變異的影響.方法 選擇2013年夏季就診于內矇古醫科大學鄂爾多斯臨床醫學院心內科門診的原髮性高血壓患者50例,8例失訪,最終研究對象為42例,按照前瞻性隨機對照研究方法分為兩組,含腎素-血管緊張素-醛固酮繫統抑製劑(RASI)組30例,鈣通道阻滯劑(CCB)組12例.Epidata 3.1軟件建立數據庫,兩組均在2013年夏季、鞦季、鼕季及2014年春季來院,收集無菌尿液,酶聯免疫吸附測定法檢測尿8-OHdG濃度,觀察兩組患者春、夏、鞦、鼕季血壓及尿8-OHdG濃度的變化.結果 RASI組與CCB組的收縮壓鼕季高于夏季[RASI組:(158±20)、(145±12) mmHg,CCB組:(158±20)、(141±9)mmHg],舒張壓鼕季高于夏季[RASI組:(101±13)、(93±9) mmHg,CCB組:(100±4)、(90±7) mmHg],差異均有統計學意義(P均＜0.05).RASI組尿8-OhdG濃度夏季和鞦季高于鼕季和春季[夏季:(243.20±30.94) ng/L,鞦季:(240.40±47.99) ng/L,鼕季:(190.80±15.56) ng/L,春季:(189.06±13.56) ng/L],差異均有統計學意義(P均＜0.001);CCB組春、夏、鞦、鼕季比較差異均無統計學意義(P均＞0.05).結論 原髮性高血壓患者經口服CCB以及含RASI為基礎治療藥物的降壓治療,血壓的季節性變異仍然存在,鼕季血壓高于夏季;以含有RASI為基礎治療藥物的降壓治療,可以使鼕季的氧化應激水平明顯降低.
목적 관찰량충강압치료방법대원발성고혈압환자혈압화뇨8간기탈양조감(8-OHdG)계절성변이적영향.방법 선택2013년하계취진우내몽고의과대학악이다사림상의학원심내과문진적원발성고혈압환자50례,8례실방,최종연구대상위42례,안조전첨성수궤대조연구방법분위량조,함신소-혈관긴장소-철고동계통억제제(RASI)조30례,개통도조체제(CCB)조12례.Epidata 3.1연건건립수거고,량조균재2013년하계、추계、동계급2014년춘계래원,수집무균뇨액,매련면역흡부측정법검측뇨8-OHdG농도,관찰량조환자춘、하、추、동계혈압급뇨8-OHdG농도적변화.결과 RASI조여CCB조적수축압동계고우하계[RASI조:(158±20)、(145±12) mmHg,CCB조:(158±20)、(141±9)mmHg],서장압동계고우하계[RASI조:(101±13)、(93±9) mmHg,CCB조:(100±4)、(90±7) mmHg],차이균유통계학의의(P균＜0.05).RASI조뇨8-OhdG농도하계화추계고우동계화춘계[하계:(243.20±30.94) ng/L,추계:(240.40±47.99) ng/L,동계:(190.80±15.56) ng/L,춘계:(189.06±13.56) ng/L],차이균유통계학의의(P균＜0.001);CCB조춘、하、추、동계비교차이균무통계학의의(P균＞0.05).결론 원발성고혈압환자경구복CCB이급함RASI위기출치료약물적강압치료,혈압적계절성변이잉연존재,동계혈압고우하계;이함유RASI위기출치료약물적강압치료,가이사동계적양화응격수평명현강저.
Objective To investigate anti-hypertension threapy on seasonal variability of blood pressure,urinary 8-OHdG levels in essential hypertension in order to provide a basis for seasonal antihypertensive treatment.Methods Fifty hypertensive patients admitted the hospital of Erdos Clinical Medical College of Inner Mongolia Medical University at summer 2013 were selected as our subjects.The final subjects was 42 cases due to 8 lost cases.The patients were randomly divided into two groups,including 30 cases in renin angiotensin aldosterone system inhibitors(RASI) group and 12 cases in Ca2+ channel blocker(CCB) group.Epidata 3.1 software was applied to perform statistic analysis.Urinary 8-OHdG concentration was measured by enzyme-linked immunosorbent assay (ELISA).Blood pressure was measured in spring,summer,autumn and winter.Results Systolic blood pressure(SBP) in RASI group and CCB group at winter periods were (158±20) mmHg,(158 ± 20) mmHg,higher than that in summer periods ((145 ± 12) mmHg,(141 ± 9) mmHg;P＜ 0.05).Diastolic blood pressure(DPB) in RASI group and CCB group at winter periods were (101 ± 13)mmHg and (100±4)mmHg,significant high than that in summer periods ((93 ±7) mmHg,(90±7) mmHg;P＜0.05).8-OhdG levels in RASI group at summer and autumn periods were (243.20±30.94) ng/L and (240.40±47.99) ng/L,significantly higher than that in winter and spring periods((190.80± 15.56) ng/L and (189.06± 13.56) ng/L),and the differences were significant(P＜0.001).No significant differences were seen in CCB group among 4 seasons in terms of 8-OhdG levels (P ＞ 0.05).Conclusion Blood pressure change still occur among 4 seasons in hypertensive patients after a single CCB containing RASI-based drug antihypertensive therapy.And blood pressure in winter periods is higher than that in summer,which indicates that therapy medication based on RASI might reduce the level of oxidative stress at winter periods.
