中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
5期
410-413
,共4页
辛伐他汀%丹红注射液%不稳定型心绞痛%超敏C反应蛋白
辛伐他汀%丹紅註射液%不穩定型心絞痛%超敏C反應蛋白
신벌타정%단홍주사액%불은정형심교통%초민C반응단백
Simvastatin%Danhong injection%Unstable anginapectoris%High-sensitivity C-reactive protein
目的 探讨辛伐他汀联合丹红注射液对不稳定型心绞痛患者的疗效.方法 选取我院心内科2010年3月至2013年12月住院治疗的不稳定型心绞痛患者90例,应用随机数字表分为对照组40例及辛伐他汀联合丹红注射液治疗组(联合组)50例.在常规治疗的基础上,对照组给予辛伐他汀20mg/d,睡前顿服,连服15 d.联合组在常规治疗基础上加用辛伐他汀20 mg/d,睡前顿服,连服15 d;丹红注射液30 ml加入生理盐水250ml中静脉输注,1次/d,连用15 d.检测两组患者治疗前后血流变、血清超敏C反应蛋白(hs-CRP),并观察两组患者的治疗效果.结果 对照组总有效率为70.0％ (28/40),联合组为84.0％ (42/50),差异有统计学意义(x2=5.738,P=0.039);对照组治疗前和治疗后血清hs-CRP分别为(18.6±4.7)mg/L和(7.6±2.1)mg/L,差异有统计学意义(t=7.484,P=0.007);联合组治疗前和治疗后分别为(19.2±4.2)mg/L和(3.6±1.7)mg/L,差异有统计学意义(t=8.644,P=0.004);联合组治疗后与对照组比较hs-CRP明显降低,差异有统计学意义(t=6.384,P=0.009);与治疗前比较,两组患者的低切黏度、血浆黏度及红细胞聚集指数均明显降低,差异均有统计学意义(P均＜0.05);联合组治疗后与对照组比较,低切黏度、高切黏度、血浆黏度及红细胞聚集指数降低,差异均有统计学意义(t值分别为5.142、4.672、5.738、5.354,P均＜0.05).结论 辛伐他汀联合丹红注射液可以有效改善老年不稳定型心绞痛患者的血流变,降低炎性反应,改善患者微循环,具有较好的临床疗效.
目的 探討辛伐他汀聯閤丹紅註射液對不穩定型心絞痛患者的療效.方法 選取我院心內科2010年3月至2013年12月住院治療的不穩定型心絞痛患者90例,應用隨機數字錶分為對照組40例及辛伐他汀聯閤丹紅註射液治療組(聯閤組)50例.在常規治療的基礎上,對照組給予辛伐他汀20mg/d,睡前頓服,連服15 d.聯閤組在常規治療基礎上加用辛伐他汀20 mg/d,睡前頓服,連服15 d;丹紅註射液30 ml加入生理鹽水250ml中靜脈輸註,1次/d,連用15 d.檢測兩組患者治療前後血流變、血清超敏C反應蛋白(hs-CRP),併觀察兩組患者的治療效果.結果 對照組總有效率為70.0％ (28/40),聯閤組為84.0％ (42/50),差異有統計學意義(x2=5.738,P=0.039);對照組治療前和治療後血清hs-CRP分彆為(18.6±4.7)mg/L和(7.6±2.1)mg/L,差異有統計學意義(t=7.484,P=0.007);聯閤組治療前和治療後分彆為(19.2±4.2)mg/L和(3.6±1.7)mg/L,差異有統計學意義(t=8.644,P=0.004);聯閤組治療後與對照組比較hs-CRP明顯降低,差異有統計學意義(t=6.384,P=0.009);與治療前比較,兩組患者的低切黏度、血漿黏度及紅細胞聚集指數均明顯降低,差異均有統計學意義(P均＜0.05);聯閤組治療後與對照組比較,低切黏度、高切黏度、血漿黏度及紅細胞聚集指數降低,差異均有統計學意義(t值分彆為5.142、4.672、5.738、5.354,P均＜0.05).結論 辛伐他汀聯閤丹紅註射液可以有效改善老年不穩定型心絞痛患者的血流變,降低炎性反應,改善患者微循環,具有較好的臨床療效.
목적 탐토신벌타정연합단홍주사액대불은정형심교통환자적료효.방법 선취아원심내과2010년3월지2013년12월주원치료적불은정형심교통환자90례,응용수궤수자표분위대조조40례급신벌타정연합단홍주사액치료조(연합조)50례.재상규치료적기출상,대조조급여신벌타정20mg/d,수전돈복,련복15 d.연합조재상규치료기출상가용신벌타정20 mg/d,수전돈복,련복15 d;단홍주사액30 ml가입생리염수250ml중정맥수주,1차/d,련용15 d.검측량조환자치료전후혈류변、혈청초민C반응단백(hs-CRP),병관찰량조환자적치료효과.결과 대조조총유효솔위70.0％ (28/40),연합조위84.0％ (42/50),차이유통계학의의(x2=5.738,P=0.039);대조조치료전화치료후혈청hs-CRP분별위(18.6±4.7)mg/L화(7.6±2.1)mg/L,차이유통계학의의(t=7.484,P=0.007);연합조치료전화치료후분별위(19.2±4.2)mg/L화(3.6±1.7)mg/L,차이유통계학의의(t=8.644,P=0.004);연합조치료후여대조조비교hs-CRP명현강저,차이유통계학의의(t=6.384,P=0.009);여치료전비교,량조환자적저절점도、혈장점도급홍세포취집지수균명현강저,차이균유통계학의의(P균＜0.05);연합조치료후여대조조비교,저절점도、고절점도、혈장점도급홍세포취집지수강저,차이균유통계학의의(t치분별위5.142、4.672、5.738、5.354,P균＜0.05).결론 신벌타정연합단홍주사액가이유효개선노년불은정형심교통환자적혈류변,강저염성반응,개선환자미순배,구유교호적림상료효.
Objective To investigate effect of Danhong injection combined with atorvastatin treatment of patients with unstable anginapectoris.Methods Ninety patients with unstable anginapectoris from Mar.2010to Dec.2013 in the First People's Hospital were selected and randomly grouped as control group(n=40) and atorvastatin-Danhong injection group(n =50).All patients in two groups were treated with routine therapy,and patients in the atorvastatin-Danhong injection group were also treated with atorvastatin at dose of 20 mg per day for 15 days and Danhong injection at dose of 30 ml in 250 ml physiological saline per day for 15 days.The level of high-sensitivity C-reactive protdn(hs-CRP) in serum and the haemodynamics of two groups during before and post-treatment were measured and analyzed.Results The effective rate of atorvastatin-Danhong injection group was 84.0％ (42/50),higher than that in control group (70.0％ (28/40),x2 =5.738,P =0.039).The level of hs-CRP in two groups at after treatment were (7.6±2.1) and (3.6±1.7) mg/L,lower than those at pretreatment((1 8.6±4.7) mg/L,(19.2±4.2) mg/L),and the differences were significant (t =8.644,7.848;P =0.004,0.007).Compared with control group after treatment,the level of hs-CRP in atorvastatin-Danhong injection group decreased rapidly (t =6.384,P =0.009).Compared with pre-treatment,the low cut blood viscosity(LCBV),high shearrate blood viscosity(HSBV),plasma viscosity and red cell assembling index in two groups were decreased remarkably(P＜0.05).Compared with control group at post-treatment,the LCBV,HSBV,plasma viscosity and red cell assembling index in atorvastatin-Danhong injection group were significantly declined (t=5.142,4.672,5.738,5.354;P＜0.05).Conclusion Danhong injection combine with atorvastatin improves the haemodynamics in patients with unstable anginapectoris and induce the inflammatory reaction,and it has the better the effects.
