中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
5期
413-416
,共4页
杨美荣%杨艳红%张国顺%王国立%路静
楊美榮%楊豔紅%張國順%王國立%路靜
양미영%양염홍%장국순%왕국립%로정
慢性乙型肝炎病毒感染%慢加急性肝衰竭%影响因素
慢性乙型肝炎病毒感染%慢加急性肝衰竭%影響因素
만성을형간염병독감염%만가급성간쇠갈%영향인소
Chronic HBV infection%Acute-on-chronic liver failure%Influencing factor
目的 探讨慢性乙型肝炎病毒(HBV)感染并发慢加急性肝衰竭的影响因素.方法 选择2008年7月至2013年12月在河北联合大学附属医院住院的慢性HBV感染并发慢加急性肝衰竭患者186例(病例组),选择同期住院的慢性HBV感染患者186为对照组.采用面对面问卷方式填写调查表,分析HBV感染并发慢加急性肝衰竭的影响因素.结果 多因素条件Logistic回归分析显示:影响慢性HBV感染并发慢加急性肝衰竭的9个变量如下:8个危险因素:病毒重叠感染(OR=6.523,95％CI:2.034～10.030),药物应用(OR=9.012,95％ CI:3.018～13.241),饮酒(OR=7.252,95％ CI:1.985 ～11.247),细菌感染(OR=4.378,95％CI:2.032～5.648),外科手术(OR=8.514,95％CI:2.114～17.253),情绪紧张及劳累(OR=2.217,95％ CI:1.729～5.648),遗传(OR=11.124,95％ CI:2.168～13.429),高PCR-HBV DNA定量(OR=1.628,95％ CI:1.504～3.282);1个保护因素:使用抗病毒药物(OR=0.163,95％CI:0.085～0.417).结论 病毒重叠感染、应用肝毒性药物、病前饮酒、细菌感染、外科手术、情绪紧张及劳累、父母遗传、高PCR-HBV DNA定量是影响慢性HBV感染并发慢加急性肝衰竭的因素,使用抗病毒药物是保护性因素.
目的 探討慢性乙型肝炎病毒(HBV)感染併髮慢加急性肝衰竭的影響因素.方法 選擇2008年7月至2013年12月在河北聯閤大學附屬醫院住院的慢性HBV感染併髮慢加急性肝衰竭患者186例(病例組),選擇同期住院的慢性HBV感染患者186為對照組.採用麵對麵問捲方式填寫調查錶,分析HBV感染併髮慢加急性肝衰竭的影響因素.結果 多因素條件Logistic迴歸分析顯示:影響慢性HBV感染併髮慢加急性肝衰竭的9箇變量如下:8箇危險因素:病毒重疊感染(OR=6.523,95％CI:2.034～10.030),藥物應用(OR=9.012,95％ CI:3.018～13.241),飲酒(OR=7.252,95％ CI:1.985 ～11.247),細菌感染(OR=4.378,95％CI:2.032～5.648),外科手術(OR=8.514,95％CI:2.114～17.253),情緒緊張及勞纍(OR=2.217,95％ CI:1.729～5.648),遺傳(OR=11.124,95％ CI:2.168～13.429),高PCR-HBV DNA定量(OR=1.628,95％ CI:1.504～3.282);1箇保護因素:使用抗病毒藥物(OR=0.163,95％CI:0.085～0.417).結論 病毒重疊感染、應用肝毒性藥物、病前飲酒、細菌感染、外科手術、情緒緊張及勞纍、父母遺傳、高PCR-HBV DNA定量是影響慢性HBV感染併髮慢加急性肝衰竭的因素,使用抗病毒藥物是保護性因素.
목적 탐토만성을형간염병독(HBV)감염병발만가급성간쇠갈적영향인소.방법 선택2008년7월지2013년12월재하북연합대학부속의원주원적만성HBV감염병발만가급성간쇠갈환자186례(병례조),선택동기주원적만성HBV감염환자186위대조조.채용면대면문권방식전사조사표,분석HBV감염병발만가급성간쇠갈적영향인소.결과 다인소조건Logistic회귀분석현시:영향만성HBV감염병발만가급성간쇠갈적9개변량여하:8개위험인소:병독중첩감염(OR=6.523,95％CI:2.034～10.030),약물응용(OR=9.012,95％ CI:3.018～13.241),음주(OR=7.252,95％ CI:1.985 ～11.247),세균감염(OR=4.378,95％CI:2.032～5.648),외과수술(OR=8.514,95％CI:2.114～17.253),정서긴장급로루(OR=2.217,95％ CI:1.729～5.648),유전(OR=11.124,95％ CI:2.168～13.429),고PCR-HBV DNA정량(OR=1.628,95％ CI:1.504～3.282);1개보호인소:사용항병독약물(OR=0.163,95％CI:0.085～0.417).결론 병독중첩감염、응용간독성약물、병전음주、세균감염、외과수술、정서긴장급로루、부모유전、고PCR-HBV DNA정량시영향만성HBV감염병발만가급성간쇠갈적인소,사용항병독약물시보호성인소.
Objective To investigate the influence factors of chronic hepatitis B virus(HBV) infection complicated with chronic liver failure.Methods One hundred and eighty-six chronic HBV infection patients with chronic liver failure were selected as our subjects,who were hospitalized in the Affiliated Hospital of Hebei United University from Jul.2008 to Dec.2013 and they served as case group.Meanwhile,186 patients with chronic HBV infection were selected and served as control group,who were hospitalized during the same period.A self-mad questionnaire was used to collect the information.The influence factors related to HBV infection complicated with acute on chronic liver failure were recorded.Results Multivariate conditional Logistic regression analysis showed that 8 variables were risk factors in terms of chronic HBV infection complicated with acute on chronic liver failure and they were virus overlap infection (OR =6.523,95％ CI:2.034 -10.030),drug application (OR =9.012,95％ CI:3.018-13.241),alcohol (OR =7.2520,95％ CI:1.985 -11.247),bacterial infection(OR =4.378,95％ CI:2.032-5.648),surgical operation (OR =8.514,95％ CI:2.114-17.253),emotional stress and fatigue (OR =2.217,95％ CI:1.729-5.648),genetic (OR =11.124,95％ CI:2.168-13.429),high PCR-HBVDNA quantity (OR =1.628,95％ CI:1.504-3.282).And one protective factorwas the usage of antiviral drug(OR=0.163,95％CI:0.085-0.417).Conclusion The risk factors include virus over infection,application of hepatotoxic drugs,disease before drinking,bacterial infection,surgical operation,emotional stress and fatigue,the genetic parents and high PCR-HBVDNA quantification;and antiviral drugs application is the protective factor in terms of Chronic HBV infection complicated with acute-on-chronic liver failure.
