CAJ | 학술논문

目的探讨艾司西酞普兰与盐酸舍曲林治疗老年性卒中后抑郁的有效性及安全性。 　　方法将80例老年性卒中后抑郁患者随机分为艾司西酞普兰组（10mg/d）和盐酸舍曲林组（50mg/d），每组各40例，疗程6周，两组的基础治疗相同并辅以心理治疗。在治疗第l、2、4、6周，盲法评定两组的汉密尔顿抑郁量表（Hamilton Depression Scale，HAMD）、美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale，NIHSS）、贝斯指数（Barthel index，BI）并进行比较。 　　结果艾司西酞普兰组与盐酸舍曲林组HAMD、NIHSS评分在第2、4、6周较本组治疗前均有显著降低（P均＜0.001），但组间无显著差异，治疗第4、6周艾司西酞普兰组BI指数高于盐酸舍曲林组（P=0.016，P=0.025）。 　　结论艾司西酞普兰与盐酸舍曲林结合心理治疗均能改善老年性卒中后抑郁症状和神经功能；在短期日常生活能力改善方面，艾司西酞普兰优于盐酸舍曲林。
목적탐토애사서태보란여염산사곡림치료노년성졸중후억욱적유효성급안전성。 　　방법장80례노년성졸중후억욱환자수궤분위애사서태보란조（10mg/d）화염산사곡림조（50mg/d），매조각40례，료정6주，량조적기출치료상동병보이심리치료。재치료제l、2、4、6주，맹법평정량조적한밀이돈억욱량표（Hamilton Depression Scale，HAMD）、미국국립위생연구원졸중량표（National Institutes of Health Stroke Scale，NIHSS）、패사지수（Barthel index，BI）병진행비교。 　　결과애사서태보란조여염산사곡림조HAMD、NIHSS평분재제2、4、6주교본조치료전균유현저강저（P균＜0.001），단조간무현저차이，치료제4、6주애사서태보란조BI지수고우염산사곡림조（P=0.016，P=0.025）。 　　결론애사서태보란여염산사곡림결합심리치료균능개선노년성졸중후억욱증상화신경공능；재단기일상생활능력개선방면，애사서태보란우우염산사곡림。
Objective To evaluate the efifcacy and safety of escitalopram and sertraline in the treatment of senile post-stroke depression. Methods Eighty patients with senile post-stroke depression were divided into treatment group and control group with 40 cases in each. The treatment group was given escitalopram combined with routine cerebrovascular disease drug treatment, the control group received sertraline combined with routine cerebrovascular disease drug treatment. In the treatment of 1, 2, 4, 6 weeks, Hamilton Depression Scale (HAMD), National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI) were used and their scores were compared. Results In the treatment group and the control group, HAMD, NIHSS scores were signiifcantly improved, but no significant difference between groups, BI index difference had statistical signiifcance in the treatment of the fourth and sixth week (P=0.016,P=0.025). Conclusion Escitalopram have signiifcant effects on treatment of senile post-stroke depression, and the ability of daily life is better than the sertraline group.