中国卒中杂志
中國卒中雜誌
중국졸중잡지
CHINESE JOURNAL OF STROKE
2015年
8期
672-677
,共6页
缺血性卒中%青年%病因分型%危险因素
缺血性卒中%青年%病因分型%危險因素
결혈성졸중%청년%병인분형%위험인소
Ischemic stroke%Young adults%Etiology classiifcation%Risk factors
目的探讨青年缺血性卒中患者的病因分型构成特点和相关危险因素。<br> 方法回顾性分析北京市海淀医院神经内科2010年1月～2014年6月连续登记的120例青年首发缺血性卒中患者，同时选取同期住院的中老年缺血性卒中患者136例作为对照，收集所有研究对象的临床资料，根据中国缺血性卒中亚型（China Ischemic Stroke Subclassification，CISS）明确所有研究对象的病因分型及其危险因素，比较两组患者的病因分型特点及相关危险因素特点。<br> 结果青年缺血性卒中组男性82例（68.3%），女性38例（31.7%）；中老年组男性76例（55.9%），女性60例（44.1%）。两组性别相比差异具有显著性（χ2=4.183，P=0.041）。CISS分型青年组依次为大动脉粥样硬化（large artery atherosclerosis，LAA）25.8%，原因不明（stroke of other undetermined etiology， SUE）22.5%，穿支动脉闭塞（perforating branch artery occlusion，PAO）20.8%，心源性（cardioembolism， CE）19.2%，其他病因（stroke of other etiology，SOE）11.7%。中老年组依次为LAA 40.5%，PAO 33.8%， CE 21.3%，SOE 2.9%，SUE 1.5%。青年缺血性卒中和中老年缺血性卒中两组间病因分型除CE差异无显著性外，LAA、PAO、SOE、SUE两组比较均差异具有显著性（P＜0.05）。其中青年组SOE、SUE病因分型比例明显高于中老年组，差异有显著性（P＜0.05）。青年组排前5位的危险因素分别是吸烟48.3%，高血压44.2%，高脂血症40.8%，饮酒36.7%，卒中家族史23.3%。而中老年组分别是高血压57.4%，糖尿病47.1%，高脂血症43.4%，颈动脉粥样硬化37.5%，吸烟35.3%。两组间相关危险因素比较，青年组吸烟、饮酒、卒中家族史明显高于中老年组，两组比较差异有显著性（P＜0.05）。<br> 结论青年缺血性卒中病因分型构成特点和相关危险因素与中老年患者分布不同。早期明确病因分型和发现危险因素有利于青年缺血性卒中的防治。
目的探討青年缺血性卒中患者的病因分型構成特點和相關危險因素。<br> 方法迴顧性分析北京市海澱醫院神經內科2010年1月～2014年6月連續登記的120例青年首髮缺血性卒中患者，同時選取同期住院的中老年缺血性卒中患者136例作為對照，收集所有研究對象的臨床資料，根據中國缺血性卒中亞型（China Ischemic Stroke Subclassification，CISS）明確所有研究對象的病因分型及其危險因素，比較兩組患者的病因分型特點及相關危險因素特點。<br> 結果青年缺血性卒中組男性82例（68.3%），女性38例（31.7%）；中老年組男性76例（55.9%），女性60例（44.1%）。兩組性彆相比差異具有顯著性（χ2=4.183，P=0.041）。CISS分型青年組依次為大動脈粥樣硬化（large artery atherosclerosis，LAA）25.8%，原因不明（stroke of other undetermined etiology， SUE）22.5%，穿支動脈閉塞（perforating branch artery occlusion，PAO）20.8%，心源性（cardioembolism， CE）19.2%，其他病因（stroke of other etiology，SOE）11.7%。中老年組依次為LAA 40.5%，PAO 33.8%， CE 21.3%，SOE 2.9%，SUE 1.5%。青年缺血性卒中和中老年缺血性卒中兩組間病因分型除CE差異無顯著性外，LAA、PAO、SOE、SUE兩組比較均差異具有顯著性（P＜0.05）。其中青年組SOE、SUE病因分型比例明顯高于中老年組，差異有顯著性（P＜0.05）。青年組排前5位的危險因素分彆是吸煙48.3%，高血壓44.2%，高脂血癥40.8%，飲酒36.7%，卒中傢族史23.3%。而中老年組分彆是高血壓57.4%，糖尿病47.1%，高脂血癥43.4%，頸動脈粥樣硬化37.5%，吸煙35.3%。兩組間相關危險因素比較，青年組吸煙、飲酒、卒中傢族史明顯高于中老年組，兩組比較差異有顯著性（P＜0.05）。<br> 結論青年缺血性卒中病因分型構成特點和相關危險因素與中老年患者分佈不同。早期明確病因分型和髮現危險因素有利于青年缺血性卒中的防治。
목적탐토청년결혈성졸중환자적병인분형구성특점화상관위험인소。<br> 방법회고성분석북경시해정의원신경내과2010년1월～2014년6월련속등기적120례청년수발결혈성졸중환자，동시선취동기주원적중노년결혈성졸중환자136례작위대조，수집소유연구대상적림상자료，근거중국결혈성졸중아형（China Ischemic Stroke Subclassification，CISS）명학소유연구대상적병인분형급기위험인소，비교량조환자적병인분형특점급상관위험인소특점。<br> 결과청년결혈성졸중조남성82례（68.3%），녀성38례（31.7%）；중노년조남성76례（55.9%），녀성60례（44.1%）。량조성별상비차이구유현저성（χ2=4.183，P=0.041）。CISS분형청년조의차위대동맥죽양경화（large artery atherosclerosis，LAA）25.8%，원인불명（stroke of other undetermined etiology， SUE）22.5%，천지동맥폐새（perforating branch artery occlusion，PAO）20.8%，심원성（cardioembolism， CE）19.2%，기타병인（stroke of other etiology，SOE）11.7%。중노년조의차위LAA 40.5%，PAO 33.8%， CE 21.3%，SOE 2.9%，SUE 1.5%。청년결혈성졸중화중노년결혈성졸중량조간병인분형제CE차이무현저성외，LAA、PAO、SOE、SUE량조비교균차이구유현저성（P＜0.05）。기중청년조SOE、SUE병인분형비례명현고우중노년조，차이유현저성（P＜0.05）。청년조배전5위적위험인소분별시흡연48.3%，고혈압44.2%，고지혈증40.8%，음주36.7%，졸중가족사23.3%。이중노년조분별시고혈압57.4%，당뇨병47.1%，고지혈증43.4%，경동맥죽양경화37.5%，흡연35.3%。량조간상관위험인소비교，청년조흡연、음주、졸중가족사명현고우중노년조，량조비교차이유현저성（P＜0.05）。<br> 결론청년결혈성졸중병인분형구성특점화상관위험인소여중노년환자분포불동。조기명학병인분형화발현위험인소유리우청년결혈성졸중적방치。
Objective To investigate the etiology classiifcation features and related risk factors of ischemic stroke in young adults. <br> Methods We retrospectively analyzed the clinical data of 120 successive patients with ifrst-ever ischemic stroke in young adults from January 2010 to June 2014 in the Department of Neurology, Beijing Haidian Hospital as young patient group. And 136 middle-aged and old patients with ischemic stroke were selected randomly as control group. The clinical data of all the subjects were collected. The study was to identify the etiology classification and related risk factors in whole cohort, and further to compare the difference between the two groups in above characteristics based on China Ischemic Stroke Subclassiifcation (CISS). <br> Results There were 82 (68.3%) male and 38 (31.7%) female in young ischemic stroke group. There were 76 (55.9%) male and 60 (44.1%) female in the control group. Male stroke incidence in the young group was significantly higher than in the elderly group (χ2=4.183,P=0.041). The CISS classification in young patient group was as follows: large artery atherosclerotic (LAA)25.8%, stroke of other undetermined etiology (SUE) 22.5%, perforating branch artery occlusion (PAO) 20.8%, cardioembolism (CE) 19.2%, stroke of other etiology (SOE) 11.7%. Middle-aged and old patient group showed LAA 40.5%, PAO 33.8%, CE 21.3%, SOE 2.9%, SUE 1.5%. LAA, PAO, SOE, SUE between the two groups were significantly different except CE (P<0.05). The youth group SOE, SUE etiology classification was obviously higher than in the control group, and the difference was significant (P<0.05). Young ischemic stroke risk factors of the top 5 are smoking 48.3%, hypertension 44.2%, hyperlipidemia 40.8%, alcohol drinking 36.7%, family history of stroke 23.3%. In contrast, the middle-aged stroke group is hypertension 57.4%, diabetes 47.1%, hyperlipidemia 43.4%, carotid atherosclerosis 37.5%, smoking 35.3%. Comparison of risk factors between the two groups, young group, smoking, drinking and family history of stroke was signiifcantly higher than that in the middle-aged and old group.There was signiifcant difference between two groups (P<0.05). <br> Conclusion Young ischemic stroke etiology classiifcation characteristics and related risk factors differ from the middle-aged and old patients. Early etiological classiifcation and detection of risk factors are beneifcial to the prevention and treatment for ischemic stroke in young adults.
