CAJ | 학술논문

代谢组学是系统生物学的重要组成部分。研究显示，代谢组学在临床诊断过程中有着不可比拟的作用。当机体受到外源性或内源性刺激时，体内小分子代谢物的种类及含量会发生显著改变，代谢组学技术通过对体内复杂代谢物的动态变化进行分析，分析代谢物变化与机体病理或生理变化的直接相关性。随着分析技术的不断发展，核磁共振、色谱-质谱联用等先进技术被广泛应用于代谢组学的研究中。目前临床运用代谢组学技术可以全面分析患者体液中代谢物的动态变化，发现体液中与疾病密切相关的特征性生物标志物，从而实现疾病的早期临床诊断。本文主要对代谢组学技术及其在临床诊断过程中的广泛应用作一综述。
대사조학시계통생물학적중요조성부분。연구현시，대사조학재림상진단과정중유착불가비의적작용。당궤체수도외원성혹내원성자격시，체내소분자대사물적충류급함량회발생현저개변，대사조학기술통과대체내복잡대사물적동태변화진행분석，분석대사물변화여궤체병리혹생리변화적직접상관성。수착분석기술적불단발전，핵자공진、색보-질보련용등선진기술피엄범응용우대사조학적연구중。목전림상운용대사조학기술가이전면분석환자체액중대사물적동태변화，발현체액중여질병밀절상관적특정성생물표지물，종이실현질병적조기림상진단。본문주요대대사조학기술급기재림상진단과정중적엄범응용작일종술。
Metabonomics is an important part of systems biology. Many research shows that metabonomics has an poten?tial incomparable advantages in clinical diagnosis. When human body was stimulated by exogenous or endogenous factor, it could respond throughalteration of low molecular weight metabolites. Therefore, researches of the dynamic changes of com?plex metabolites could explore the pathological or physiological changes in the body. With advance of modern technologies nuclear magnetic resonance and chromatography couple to mass spectrometer are widely applied to the metabonomics. Now, comprehensive analysis the dynamic changes of patients in vivo then setting up relationship between biomarkers and related diseases become possible through the application of Metabolomics in clinical. Finally, we discuss the realization of disease diagnosis by metabolome analysis.