天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2015年
8期
936-938
,共3页
张春风%葛焕琦%谢云%郑辉
張春風%葛煥琦%謝雲%鄭輝
장춘풍%갈환기%사운%정휘
糖尿病,2型%实时动态血糖监测%准确性%错误栅格分析
糖尿病,2型%實時動態血糖鑑測%準確性%錯誤柵格分析
당뇨병,2형%실시동태혈당감측%준학성%착오책격분석
diabetes mellitus,type 2%real-time continuous glucose monitoring%accuracy%error grid analysis
目的：探讨实时动态血糖监测（RT-CGM）在2型糖尿病（T2DM）患者中的准确性。方法选取2013年5月—2014年8月于我院住院治疗的T2DM患者318例作为研究对象。所有受试者佩戴RT-CGM检测仪，每日输入至少4个指端血糖进行校正。依指端血糖水平将受试者分为3组：≤6.99 mmol/L组、7.0~10.0 mmol/L组和≥10.01 mmol/L组，分析指端血糖与探头血糖的相关性，并应用Clarke错误栅格分析评价RT-CGM的准确性。结果（1）本研究共得到2815对指端血糖-探头血糖数据，探头血糖与指端血糖呈正相关（r=0.847），对指端血糖水平分组后分析显示：两者的相关性随血糖值的升高而升高（r分别为0.457、0.648和0.852，P＜0.001）。（2）Clarke错误栅格分析显示：RT-CGM值的临床准确率为76.69%（A区），可接受率为20.28%（B区），临床不可接受血糖比例为3.03%（C~E区）。指端血糖≤6.99 mmol/L时的临床准确率低于7.0~10.0和≥10.01 mmol/L时（73.12%vs 78.63%&79.28%，P＜0.05），而后2组水平的临床准确率差异无统计学意义。结论 RT-CGM具有良好的准确性，尤其是在高血糖时其准确性更稳定。
目的：探討實時動態血糖鑑測（RT-CGM）在2型糖尿病（T2DM）患者中的準確性。方法選取2013年5月—2014年8月于我院住院治療的T2DM患者318例作為研究對象。所有受試者珮戴RT-CGM檢測儀，每日輸入至少4箇指耑血糖進行校正。依指耑血糖水平將受試者分為3組：≤6.99 mmol/L組、7.0~10.0 mmol/L組和≥10.01 mmol/L組，分析指耑血糖與探頭血糖的相關性，併應用Clarke錯誤柵格分析評價RT-CGM的準確性。結果（1）本研究共得到2815對指耑血糖-探頭血糖數據，探頭血糖與指耑血糖呈正相關（r=0.847），對指耑血糖水平分組後分析顯示：兩者的相關性隨血糖值的升高而升高（r分彆為0.457、0.648和0.852，P＜0.001）。（2）Clarke錯誤柵格分析顯示：RT-CGM值的臨床準確率為76.69%（A區），可接受率為20.28%（B區），臨床不可接受血糖比例為3.03%（C~E區）。指耑血糖≤6.99 mmol/L時的臨床準確率低于7.0~10.0和≥10.01 mmol/L時（73.12%vs 78.63%&79.28%，P＜0.05），而後2組水平的臨床準確率差異無統計學意義。結論 RT-CGM具有良好的準確性，尤其是在高血糖時其準確性更穩定。
목적：탐토실시동태혈당감측（RT-CGM）재2형당뇨병（T2DM）환자중적준학성。방법선취2013년5월—2014년8월우아원주원치료적T2DM환자318례작위연구대상。소유수시자패대RT-CGM검측의，매일수입지소4개지단혈당진행교정。의지단혈당수평장수시자분위3조：≤6.99 mmol/L조、7.0~10.0 mmol/L조화≥10.01 mmol/L조，분석지단혈당여탐두혈당적상관성，병응용Clarke착오책격분석평개RT-CGM적준학성。결과（1）본연구공득도2815대지단혈당-탐두혈당수거，탐두혈당여지단혈당정정상관（r=0.847），대지단혈당수평분조후분석현시：량자적상관성수혈당치적승고이승고（r분별위0.457、0.648화0.852，P＜0.001）。（2）Clarke착오책격분석현시：RT-CGM치적림상준학솔위76.69%（A구），가접수솔위20.28%（B구），림상불가접수혈당비례위3.03%（C~E구）。지단혈당≤6.99 mmol/L시적림상준학솔저우7.0~10.0화≥10.01 mmol/L시（73.12%vs 78.63%&79.28%，P＜0.05），이후2조수평적림상준학솔차이무통계학의의。결론 RT-CGM구유량호적준학성，우기시재고혈당시기준학성경은정。
Objective To investigate the accuracy of real-time continuous glucose monitoring(RT-CGM)system in the type 2 diabetes mellitus(T2DM). Methods A total of 318 subjects hospitalized between 2013 May to 2014 August were recruited. Each subject received a RT-CGM system. In order to calibrate the interstitial glucose level, finger-stick blood glucose were measured at least four times every day. Patients were divided into three groups according to their finger-stick blood glucose level:≤6.99 mmol/L, 7.0-10.0 mmol/L and≥10.01 mmol/L. Pearson correlation was used to analyze the relationship between the finger-stick glucose and interstitial glucose gained from RT-CGM. Clarke error grid analysis was used to analyze the accuracy of RT-CGM. Results (1)A total of 2, 815 glucose meter values from finger-stick were com?paired with glucose from RT-CGM. A positive relationship(r=0.847)were found between CGM and finger-stick blood glu?cose. The correlation was closer with higher finger-stick blood glucose levels(r=0.457, 0.648 and 0.852 respectively in≤6.99 mmol/L group, 7.0-10.0 mmol/L group and≥10.01 mmol/L group. P<0.001).(2)The Clarke error grid analysis re?vealed that 76.69%of the readings from RT-CGM were clinical perfect (zone A), 20.28%were acceptable (zone B), 3.03%were unacceptable (zone C-E). Clinical perfect rate was lower when the finger-stick glucose≤6.99 mmol/L , compared with that when it is between 7.0-10.0 or≥10.01 mmol/L group(73.12%vs 78.63%&79.28%,P<0.05), there was no significant difference between group of 7.0-10.0 mmol/L with group≥10.01 mmol/L (P>0.05). Conclusion RT-CGM provides accu?rate blood glucose values to guide the treatment of diabetes, and the accuracy is more reliable in high glucose environment.
