CAJ | 학술논문

由蚊媒传播的疾病,如疟疾、登革热、流行性乙型脑炎、黄热病等已严重影响人类健康,但至今尚无有效的防治方法.沃尔巴克氏体是在自然界中广泛存在的、经母系遗传的共生菌,可诱导蚊群产生胞质不相容.迄今为止,胞质不相容的分子机制尚未明确,但“锁-钥匙”模型(lock and key model)、“移除-归还”模型(titration-restitution model)和“减速”模型(slow-motion model)可在一定程度上解释胞质不相容现象.胞质不相容产生的整个过程极为复杂,是多种因子共同作用的结果.该文就胞质不相容的模型及分子机制进行综述.
유문매전파적질병,여학질、등혁열、류행성을형뇌염、황열병등이엄중영향인류건강,단지금상무유효적방치방법.옥이파극씨체시재자연계중엄범존재적、경모계유전적공생균,가유도문군산생포질불상용.흘금위지,포질불상용적분자궤제상미명학,단“쇄-약시”모형(lock and key model)、“이제-귀환”모형(titration-restitution model)화“감속”모형(slow-motion model)가재일정정도상해석포질불상용현상.포질불상용산생적정개과정겁위복잡,시다충인자공동작용적결과.해문취포질불상용적모형급분자궤제진행종술.
Mosquito-borne disease such as malaria、dengue fever,epidemic,encephalitis and yellow fever has a serious impact on human health,but so far there is no effective control methods.Wolbachia are widespread in nature and are maternally inherited endosymbiontic bacteria which can induce cytoplasmic incompatibility(CI).To date,the molecular mechanism of CI has not been elucidated,but the "lock-key",the"-titration-restitution" and the "slow-motion" models could explain the phenomenon to a certain extent.The process of inducing CI is extremely complex,including variety of factors.