CAJ | 학술논문

目的：对比伏格列波糖片与阿卡波糖片对2型糖尿病的临床疗效。方法随机选择2012年1月至2013年12月来我院进行2型DM治疗的患者68例，分为伏格列波糖组与阿卡波糖组各34例。两组患者予以对症治疗，嘱患者控制饮食，适量运动。伏格列波糖组给予伏格列波糖片0.2 mg，日3次口服。用量随病情变化调整，可增至0.3毫克/次。阿卡波糖组给予阿卡波糖片50 mg，日3次，餐前即刻口服。根据患者病情酌情增加用量，最多不超过0.2 g，日3次。观察两组患者8周后的临床疗效以及不良反应发生情况。结果两组患者经过8周治疗，空腹血糖与餐后血糖均比治疗前降低，且具有统计学意义（P<0.05）。但是两组患者治疗后的血糖值无组间差异（P>0.05）。两组患者服药后均有腹胀、肠鸣音亢进、排气增多、一过性低血糖等不良反应出现，但是伏格列波糖组患者的不良反应比阿卡波糖组少，具有组间差异（P<0.05）。结论伏格列波糖片与阿卡波糖片对糖尿病的临床疗效无明显差异，但是伏格列波糖片所引起的不良反应要少于阿卡波糖片。
목적：대비복격렬파당편여아잡파당편대2형당뇨병적림상료효。방법수궤선택2012년1월지2013년12월래아원진행2형DM치료적환자68례，분위복격렬파당조여아잡파당조각34례。량조환자여이대증치료，촉환자공제음식，괄량운동。복격렬파당조급여복격렬파당편0.2 mg，일3차구복。용량수병정변화조정，가증지0.3호극/차。아잡파당조급여아잡파당편50 mg，일3차，찬전즉각구복。근거환자병정작정증가용량，최다불초과0.2 g，일3차。관찰량조환자8주후적림상료효이급불량반응발생정황。결과량조환자경과8주치료，공복혈당여찬후혈당균비치료전강저，차구유통계학의의（P<0.05）。단시량조환자치료후적혈당치무조간차이（P>0.05）。량조환자복약후균유복창、장명음항진、배기증다、일과성저혈당등불량반응출현，단시복격렬파당조환자적불량반응비아잡파당조소，구유조간차이（P<0.05）。결론복격렬파당편여아잡파당편대당뇨병적림상료효무명현차이，단시복격렬파당편소인기적불량반응요소우아잡파당편。
Objective To compare the clinical efifcacy of Voglibose tablets and Acarbose tablet on treatment of type 2 diabetes mellitus. Methods 68 cases of type 2 DM patients who were treated in our hospital from January 2012 to December 2013 were randomly divided into voglibose group and acarbose group, with 34 cases in each group. Two groups received symptomatic treatment;patients were instructed to diet control and did appropriate exercise. Voglibose group was given Voglibose tablets 0.2 mg, 3 times a day orally. The amount of was drug can be increased to a time 0.3 mg according to disease condition. Acarbose group was given Acarbose tablet 50 mg, 3 times a day, before meals oral immediately. The amount of was drug can be increased to a time 0.2 mg according to disease condition, 3 times a day. Observed two groups’ clinical efifcacy and side effects after 8 weeks of treatment. Results After 8 weeks of treatment, both two groups’ blood glucose and fasting blood glucose levels were lower than before treatment, with statistical signiifcance (P<0.05). There was no difference between two groups’ blood glucose levels after treatment (P>0.05). Two groups occurred abdominal distention, bowel cries phonic hyperfunction, increased exhaust adverse reactions, but the side effects of Voglibose group were less than Acarbose group, the difference between two groups had statistical signiifcance (P<0.05). Conclusion There is no signiifcant difference between the clinical curative effect of Voglibose tablets and Acarbose tablet on treatment type 2 diabetes, but the side effects caused by Voglibose tablets are less than Acarbose tablet.