CAJ | 학술논문

目的：观察多西他赛与顺铂在放射疗治疗中晚期食管癌的疗效及不良反应。方法将70例老年食管癌患者随机分为两组。多西他赛组35例放射治疗联合多西他赛增敏治疗，顺铂组35例采用放射疗联合顺铂增敏治疗。比较观察2组的疗效和不良反应。结果多西他赛组和顺铂组完全缓解率分别为37.1%、34.2%，差异无统计学意义(P>0.05)；两年总生存率比较差异无统计学意义(P>0.05)。两组不良反应中恶心、呕吐方面多西他赛组好于顺铂组，差异有统计学意义(P<0.05)。在骨髓抑制、放射性肺炎、放射性食管炎方面差异无统计学意义(P>0.05)。结论放射治疗联合多西他赛增敏治疗与顺铂增敏治疗疗效相近，且不增加不良反应。
목적：관찰다서타새여순박재방사료치료중만기식관암적료효급불량반응。방법장70례노년식관암환자수궤분위량조。다서타새조35례방사치료연합다서타새증민치료，순박조35례채용방사료연합순박증민치료。비교관찰2조적료효화불량반응。결과다서타새조화순박조완전완해솔분별위37.1%、34.2%，차이무통계학의의(P>0.05)；량년총생존솔비교차이무통계학의의(P>0.05)。량조불량반응중악심、구토방면다서타새조호우순박조，차이유통계학의의(P<0.05)。재골수억제、방사성폐염、방사성식관염방면차이무통계학의의(P>0.05)。결론방사치료연합다서타새증민치료여순박증민치료료효상근，차불증가불량반응。
Objective To explore the efifcacy and toxicities of radiotherapy combined with docetaxel or cisplatin in the treatment of advanced esophageal carcinoma. Methods Seventy cases of esophageal carcinoma were randomly divided into two groups:35 cases of a group received radiotherapy weekly docetaxel, 35 cases of the another group received radiotherapy combined with weekly cisplatin. After treatment, the efficacy and toxicities of the two groups were observed comparatively. Results There was no signiifcant difference in the short-term response rate and 2-year survival rates between two groups(P>0.05). There was no signiifcant difference in the incidence of myelosuppression, radiation-induced esophagitis and radiation-induced pneumonia between the two groups. The incidences of nausea, vomiting was significantly lower in the docetaxel group than in the cisplatin group. Conclusion Radiotherapy combined with docetaxel is effective and well-tolerated in patients with locally advanced esophageal carcinoma.