CAJ | 학술논문

局部pH值和氧分压(pO2)的变化可影响成骨细胞功能。成骨细胞对pH值直接影响极其敏感院酸中毒抑制成骨细胞的矿物沉积。成骨细胞对小范围pH变化反应机制较复杂，涉及对细胞膜离子通道、受体以及细胞内的直接影响。研究表明缺氧严重抑制成骨细胞的生长和分化，促进成骨细胞凋亡。在体内，由于血管灌注的减少和糖酵解代谢的增加，组织缺氧通常伴有酸中毒。血液供应的中断，使成骨细胞pO2减少和pH值降低，而对成骨细胞活动产生负面影响。该文就缺氧和酸中毒对成骨细胞的功能影响及近年研究进展作一综述。
국부pH치화양분압(pO2)적변화가영향성골세포공능。성골세포대pH치직접영향겁기민감원산중독억제성골세포적광물침적。성골세포대소범위pH변화반응궤제교복잡，섭급대세포막리자통도、수체이급세포내적직접영향。연구표명결양엄중억제성골세포적생장화분화，촉진성골세포조망。재체내，유우혈관관주적감소화당효해대사적증가，조직결양통상반유산중독。혈액공응적중단，사성골세포pO2감소화pH치강저，이대성골세포활동산생부면영향。해문취결양화산중독대성골세포적공능영향급근년연구진전작일종술。
The function of osteoblast is affected by local pH and oxygen tension. Osteoblasts are extremely sensitive to the direct effects of pH: acidosis inhibits mineral deposition by osteoblasts. The mechanisms by which osteoblasts sense small pH changes are complex, involving in channels, receptors in the cell membrane and the direct intracellular effects. Reseach shows that severe hypoxia inhibits osteoblast growth and differention, and promotes the apoptosis of osteoblasts. In vivo, tissue hypoxia usually ac-companied by acidosis due to reduced perfusion and increased glycolytic metabolism. Disruption of the blood supply can engender negative effects on osteoblasts via the direct actions of reduced pO2 and pH on osteoblasts. This article aims to review recent re-search progress which the effects of hypoxia and acidosis on proliferation and differentiation of osteoblast function.