中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
20期
191-192
,共2页
同型半胱氨酸%脑钠肽%维持性血液透析%应用价值
同型半胱氨痠%腦鈉肽%維持性血液透析%應用價值
동형반광안산%뇌납태%유지성혈액투석%응용개치
Homocysteine%Natriuretic peptide%Hemodialysis%Value
目的：探讨同型半胱氨酸(Hcy)联合脑钠肽(BNP)检测在维持性血液透析(MHD)中的应用价值。方法随机选取2010年1月-2015年1月与该院进行维持性血液透析治疗的尿毒症患者116例作为研究对象，选择50例健康体检患者为对照组。所有患者均行维持性血液透析1年以上，已排除失访病例。采集所有患者血液透析前后外周静脉血进行检查，应用放射免疫法检测透析前后BNP、Hcy指标，并根据患者透析后心血管风险事件发生率分析Hcy联合BNP在MHD中检测意义。结果血透组患者透析前Hcy、BNP指标均高于透析后(P<0.05)，并且透析前后Hcy、BNP指标均明显高于对照组(P<0.05)；随访复查中发生心血管疾病63例，其透析前后BNP及Hcy指标明显高于无并发心血管疾病患者，差异有统计学意义(P<0.05)。结论BNP联合Hcy检测可作为维持性血液透析患者心血管风险事件发生的高危预警因素，具有临床应用及推广价值。
目的：探討同型半胱氨痠(Hcy)聯閤腦鈉肽(BNP)檢測在維持性血液透析(MHD)中的應用價值。方法隨機選取2010年1月-2015年1月與該院進行維持性血液透析治療的尿毒癥患者116例作為研究對象，選擇50例健康體檢患者為對照組。所有患者均行維持性血液透析1年以上，已排除失訪病例。採集所有患者血液透析前後外週靜脈血進行檢查，應用放射免疫法檢測透析前後BNP、Hcy指標，併根據患者透析後心血管風險事件髮生率分析Hcy聯閤BNP在MHD中檢測意義。結果血透組患者透析前Hcy、BNP指標均高于透析後(P<0.05)，併且透析前後Hcy、BNP指標均明顯高于對照組(P<0.05)；隨訪複查中髮生心血管疾病63例，其透析前後BNP及Hcy指標明顯高于無併髮心血管疾病患者，差異有統計學意義(P<0.05)。結論BNP聯閤Hcy檢測可作為維持性血液透析患者心血管風險事件髮生的高危預警因素，具有臨床應用及推廣價值。
목적：탐토동형반광안산(Hcy)연합뇌납태(BNP)검측재유지성혈액투석(MHD)중적응용개치。방법수궤선취2010년1월-2015년1월여해원진행유지성혈액투석치료적뇨독증환자116례작위연구대상，선택50례건강체검환자위대조조。소유환자균행유지성혈액투석1년이상，이배제실방병례。채집소유환자혈액투석전후외주정맥혈진행검사，응용방사면역법검측투석전후BNP、Hcy지표，병근거환자투석후심혈관풍험사건발생솔분석Hcy연합BNP재MHD중검측의의。결과혈투조환자투석전Hcy、BNP지표균고우투석후(P<0.05)，병차투석전후Hcy、BNP지표균명현고우대조조(P<0.05)；수방복사중발생심혈관질병63례，기투석전후BNP급Hcy지표명현고우무병발심혈관질병환자，차이유통계학의의(P<0.05)。결론BNP연합Hcy검측가작위유지성혈액투석환자심혈관풍험사건발생적고위예경인소，구유림상응용급추엄개치。
Objective To discuss the Application with Homocysteine and brain natriuretic peptide in maintenance hemodialysis patients. Methods Selected 116 hemodialysis in uremic as study from January 2010 to January 2015 in our hospital, and selected 50 healthy people as a control group. All patients were performed maintenance hemodialysis more than 1 year, excepted those lost to follow-up. Collected all patients' peripheral venous blood before and after hemodialysis and used ria method to detect the BNP and Hcy. The incidence of cardiovascular events risk analysis Hcy joint significance of BNP testing in accordance with MHD pa-tients after dialysis. Results Hemodialysis patients before dialysis Hcy, BNP indicators were higher than after dialysis (P<0.05), and before and after dialysis Hcy, BNP indicators were significantly higher (P<0.05);63 patients with cardiovascular disease in the follow-up review, BNP and its front and rear dialysis Hcy index than those without concurrent cardiovascular disease, P<0.05, sta-tistically significant. Conclusion BNP and Hcy detect high-risk warning as cardiovascular risk factors in maintaining blood inci-dent dialysis patients, with clinical applications and promotional value.
