CAJ | 학술논문

目的：探讨半乳糖凝集素-3（Galectin-3）和β连环素（β-catenin）在子宫内膜异位症（EMs）患者的异位内膜和在位内膜中的表达及其在EMs发病中的作用及关系。方法应用免疫组织化学法检测34例EMs患者（EMs组）的异位内膜和在位内膜及30例非子宫内膜异位症（正常对照组）的在位子宫内膜中的半乳糖凝集素-3和β连环素的表达情况，并分析二者的相关性。结果半乳糖凝集素-3在EMs组异位内膜、在位内膜及正常对照组在位内膜的阳性表达率分别为88.2%、85.3%、50.0%；β连环素在上述3组的异常表达率分别为55.9%、52.9%、26.7%。EMs异位内膜组、在位内膜组的半乳糖凝集素-3的阳性表达率和β连环素的异常表达率均高于正常对照组（P＜0.05）。EMs组异位内膜、在位内膜中的半乳糖凝集素-3的阳性表达和β连环素的异常表达呈正相关（rs分别为0.512、0.428，P＜0.01）。结论半乳糖凝集素-3和β连环素可能在EMs的发病中共同起着重要作用。
목적：탐토반유당응집소-3（Galectin-3）화β련배소（β-catenin）재자궁내막이위증（EMs）환자적이위내막화재위내막중적표체급기재EMs발병중적작용급관계。방법응용면역조직화학법검측34례EMs환자（EMs조）적이위내막화재위내막급30례비자궁내막이위증（정상대조조）적재위자궁내막중적반유당응집소-3화β련배소적표체정황，병분석이자적상관성。결과반유당응집소-3재EMs조이위내막、재위내막급정상대조조재위내막적양성표체솔분별위88.2%、85.3%、50.0%；β련배소재상술3조적이상표체솔분별위55.9%、52.9%、26.7%。EMs이위내막조、재위내막조적반유당응집소-3적양성표체솔화β련배소적이상표체솔균고우정상대조조（P＜0.05）。EMs조이위내막、재위내막중적반유당응집소-3적양성표체화β련배소적이상표체정정상관（rs분별위0.512、0.428，P＜0.01）。결론반유당응집소-3화β련배소가능재EMs적발병중공동기착중요작용。
Objective To investigate the expressions and mutual relationship of Galectin-3 andβ-catenin in endome?triosis (EM). Methods Immunohistochemistry was used to detect expression levels of Galectin-3 andβ-catenin and their mutual relationship in expression was also examined. Samples were collected from ectopic endometrium of patients with en?dometriosis (ectopic endometrium group, n=34), eutopic endometrium of patients with endometriosis (eutopic endometrium group, n=34) and normal endometrium from people without endometriosis (control group, n=30). Results The expressions of Galectin-3 were seen in 88.2%, 85.3%, 50.0%of cases in ectopic endometrium group, eutopic endometrium group and control group respectively. On the other hand, the expression ofβ-catenin were seen in 55.9%, 52.9%, 26.7%of cases in ecto?pic endometrium group, eutopic endometrium group and control group respectively. In EMs patients, the expression of Galec?tin-3 andβ-catenin were significantly higher in ectopic endometrium and eutopic endometrium than those in normal endome?trium group(P<0.05). Expression of Galectin-3 was positive correlated with expression ofβ-catenin(rs=0.512, 0.428, P<0.01). Conclusion Galectin-3 andβ-catenin may play important roles synergistically in the pathogenesis of endometriosis.