天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2015年
8期
848-851
,共4页
陆潞%谢克恭%韦贵将%王俊利%陆敏安%乔宁宁%卢贤哲%唐毓金
陸潞%謝剋恭%韋貴將%王俊利%陸敏安%喬寧寧%盧賢哲%唐毓金
륙로%사극공%위귀장%왕준리%륙민안%교저저%로현철%당육금
白细胞介素12%多态性,单核苷酸%广西壮族自治区%人种群
白細胞介素12%多態性,單覈苷痠%廣西壯族自治區%人種群
백세포개소12%다태성,단핵감산%엄서장족자치구%인충군
interleukin-12%polymorphism,single nucleotide%Guangxi%ethnic group
目的:分析白细胞介素(IL)-12A基因单核苷酸多态性(SNP)位点rs568408和IL-12B基因SNP位点rs3212227的各基因型和等位基因在广西壮族人群中的分布频率,及不同地区的分布差异。方法采用单碱基延伸的PCR技术对165例广西壮族人群IL-12A rs568408和IL-12B rs3212227进行多态性检测,对比国际人类基因组计划(HapMap)公布的中国北京、日本、非洲和意大利人群的SNP分型数据,分析5个人群rs568408、rs3212227位点的基因型和等位基因频率差异。结果在广西壮族人群中存在rs568408和rs3212227多态性,2位点基因型及等位基因频率在男女性别间差异无统计学意义(P>0.05),IL-12A rs568408与北京、日本和意大利人群差异无统计学意义(P>0.05),但与非洲人群存在差异(P<0.01);IL-12B rs3212227与北京和日本人群差异无统计学意义,但与非洲和意大利人群存在差异(P<0.01)。结论 IL-12A rs568408和IL-12B rs3212227存在多态性,2位点基因型和等位基因在广西壮族人群中的分布频率与其他种族和地区人群相比存在差异,这种差异可能是导致某些疾病在不同人群发病率和临床表现存在差异的原因之一。
目的:分析白細胞介素(IL)-12A基因單覈苷痠多態性(SNP)位點rs568408和IL-12B基因SNP位點rs3212227的各基因型和等位基因在廣西壯族人群中的分佈頻率,及不同地區的分佈差異。方法採用單堿基延伸的PCR技術對165例廣西壯族人群IL-12A rs568408和IL-12B rs3212227進行多態性檢測,對比國際人類基因組計劃(HapMap)公佈的中國北京、日本、非洲和意大利人群的SNP分型數據,分析5箇人群rs568408、rs3212227位點的基因型和等位基因頻率差異。結果在廣西壯族人群中存在rs568408和rs3212227多態性,2位點基因型及等位基因頻率在男女性彆間差異無統計學意義(P>0.05),IL-12A rs568408與北京、日本和意大利人群差異無統計學意義(P>0.05),但與非洲人群存在差異(P<0.01);IL-12B rs3212227與北京和日本人群差異無統計學意義,但與非洲和意大利人群存在差異(P<0.01)。結論 IL-12A rs568408和IL-12B rs3212227存在多態性,2位點基因型和等位基因在廣西壯族人群中的分佈頻率與其他種族和地區人群相比存在差異,這種差異可能是導緻某些疾病在不同人群髮病率和臨床錶現存在差異的原因之一。
목적:분석백세포개소(IL)-12A기인단핵감산다태성(SNP)위점rs568408화IL-12B기인SNP위점rs3212227적각기인형화등위기인재엄서장족인군중적분포빈솔,급불동지구적분포차이。방법채용단감기연신적PCR기술대165례엄서장족인군IL-12A rs568408화IL-12B rs3212227진행다태성검측,대비국제인류기인조계화(HapMap)공포적중국북경、일본、비주화의대리인군적SNP분형수거,분석5개인군rs568408、rs3212227위점적기인형화등위기인빈솔차이。결과재엄서장족인군중존재rs568408화rs3212227다태성,2위점기인형급등위기인빈솔재남녀성별간차이무통계학의의(P>0.05),IL-12A rs568408여북경、일본화의대리인군차이무통계학의의(P>0.05),단여비주인군존재차이(P<0.01);IL-12B rs3212227여북경화일본인군차이무통계학의의,단여비주화의대리인군존재차이(P<0.01)。결론 IL-12A rs568408화IL-12B rs3212227존재다태성,2위점기인형화등위기인재엄서장족인군중적분포빈솔여기타충족화지구인군상비존재차이,저충차이가능시도치모사질병재불동인군발병솔화림상표현존재차이적원인지일。
Objective To investigate the frequencies of genotype and allele distribution of IL-12A gene single nucleo?tide polymorphisms (SNP) rs568408 and IL-12B gene SNP rs3212227 in Zhuang populations in Guangxi, and to compare the distribution of IL-12A and IL-12B polymorphisms among different races. Methods The IL-12A SNP rs568408 and IL-12B SNP rs3212227 were detected by SNaPshot SNP genotyping technique in 165 Zhuang people in Guangxi, frequen?cies of genotype and allele of IL-12A gene rs568408 and IL-12B rs3212227 polymorphisms were analyzed in Zhuang popu?lations compared with the other four populations(HapMap-HCB, HapMap-JPT, HapMap-YRI, HapMap-TSI)from Hap?Map database. Results There were polimorphisms of IL-12A and IL-12B gene in Zhuang populations in Guangxi. The fre?quencies of allele and genotype distribution of IL-12A gene rs568408 polymorphisms were not significantly differenct com?pared with HapMap-HCB, HapMap-JPT and HapMap-TSI(P>0.05), but were significantly different compared with Hap?Map-YRI(P<0.01);The frequencies of allele and genotype distribution of IL-12B rs3212227 polymorphisms were not sig?nificantly differenct compared with HapMap-HCB and HapMap-JPT(P>0.05), but were significantly different compared with HapMap-YRI and HapMap-TSI(P<0.01). Conclusion There are significant differences in the frequencies of allele and genotype distribution of IL-12A gene rs568408 and IL-12B gene rs3212227 between Zhuang populations and other eth?nic populations, and this variation might contribute to a variety of clinical manifestation and morbidity of some IL-12 related diseases.