中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
22期
53-55
,共3页
陈世豪%张伟坚%李珍瑶%李亮
陳世豪%張偉堅%李珍瑤%李亮
진세호%장위견%리진요%리량
中性粒细胞明胶酶相关脂质运载蛋白%高血压肾病%肾小球滤过率
中性粒細胞明膠酶相關脂質運載蛋白%高血壓腎病%腎小毬濾過率
중성립세포명효매상관지질운재단백%고혈압신병%신소구려과솔
Neutrophil gelatinase-associated lipocalin%Hypertensive nephropathy%Gluomerular filtoation rate
目的：探讨尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、肾小球滤过率（GFR）和血清胱抑素C（CysC）之间的关系，以及NGAL在原发性高血压（EH）肾损伤患者中应用。方法：选择本院内科2013年10月-2014年5月已确诊原发性高血压（EH组）患者65例，根据尿白蛋白排泄率（UAER）标准又分为三组，正常白蛋白尿（NA）23例，微量白蛋白尿（MA）27例，临床白蛋白尿（CN）15例，另随机选取体检中心健康人群25例为对照组，尿NGAL和血清CysC等指标由全自动生化分析仪检测，以Cockroff-Gault公式计算GFR。结果：EH组患者尿NGAL水平明显高于对照组，比较差异有统计学意义（P<0.01）。尿NGAL水平在三组有明显差异，且其水平与UAER严重程度呈正相关；与NA组相比，MA组和CN组尿NGAL水平明显升高，比较差异均有统计学意义（P<0.01）。另外，尿NGAL与eGFR呈负相关（r=-0.729，P<0.01），而与血清CysC呈正相关（r=0.773，P<0.01）。结论：尿NGAL水平在高血压患者中显著升高，并且与肾损伤程度成正相关，尿NGAL可作为原发性高血压患者早期肾损伤的诊断和治疗效果的指标。
目的：探討尿中性粒細胞明膠酶相關脂質運載蛋白（NGAL）、腎小毬濾過率（GFR）和血清胱抑素C（CysC）之間的關繫，以及NGAL在原髮性高血壓（EH）腎損傷患者中應用。方法：選擇本院內科2013年10月-2014年5月已確診原髮性高血壓（EH組）患者65例，根據尿白蛋白排洩率（UAER）標準又分為三組，正常白蛋白尿（NA）23例，微量白蛋白尿（MA）27例，臨床白蛋白尿（CN）15例，另隨機選取體檢中心健康人群25例為對照組，尿NGAL和血清CysC等指標由全自動生化分析儀檢測，以Cockroff-Gault公式計算GFR。結果：EH組患者尿NGAL水平明顯高于對照組，比較差異有統計學意義（P<0.01）。尿NGAL水平在三組有明顯差異，且其水平與UAER嚴重程度呈正相關；與NA組相比，MA組和CN組尿NGAL水平明顯升高，比較差異均有統計學意義（P<0.01）。另外，尿NGAL與eGFR呈負相關（r=-0.729，P<0.01），而與血清CysC呈正相關（r=0.773，P<0.01）。結論：尿NGAL水平在高血壓患者中顯著升高，併且與腎損傷程度成正相關，尿NGAL可作為原髮性高血壓患者早期腎損傷的診斷和治療效果的指標。
목적：탐토뇨중성립세포명효매상관지질운재단백（NGAL）、신소구려과솔（GFR）화혈청광억소C（CysC）지간적관계，이급NGAL재원발성고혈압（EH）신손상환자중응용。방법：선택본원내과2013년10월-2014년5월이학진원발성고혈압（EH조）환자65례，근거뇨백단백배설솔（UAER）표준우분위삼조，정상백단백뇨（NA）23례，미량백단백뇨（MA）27례，림상백단백뇨（CN）15례，령수궤선취체검중심건강인군25례위대조조，뇨NGAL화혈청CysC등지표유전자동생화분석의검측，이Cockroff-Gault공식계산GFR。결과：EH조환자뇨NGAL수평명현고우대조조，비교차이유통계학의의（P<0.01）。뇨NGAL수평재삼조유명현차이，차기수평여UAER엄중정도정정상관；여NA조상비，MA조화CN조뇨NGAL수평명현승고，비교차이균유통계학의의（P<0.01）。령외，뇨NGAL여eGFR정부상관（r=-0.729，P<0.01），이여혈청CysC정정상관（r=0.773，P<0.01）。결론：뇨NGAL수평재고혈압환자중현저승고，병차여신손상정도성정상관，뇨NGAL가작위원발성고혈압환자조기신손상적진단화치료효과적지표。
Objective:To study the relationship between urine NGAL(Neutrophil gelatinase-associatedlipocalin), GFR(gluomerular filtoation rate)and serum CysC(cystatin C),and explore the important role of urine NGAL in assessment of renal injury in patients with essential hypertension. Method:Total of 65 patients with essential hypertension,admitted to the Department of neurology at Xinhui Hospital from October 2013 to May 2014,was enrolled in this study,according to UAER (urinary microalbumin excreting rate),divided into group NA(normal albuminuria,n=23),group MA(microalbuminuria, n=27),group CN(clinicalnephropathy,n=15),and 25 healthy people into control group. The urine NGAL and cystatin C and other indices was assessed by use of fully automatic biochemical,and the GFR based on Cockroff-Gault fomula. Result:The urine NGAL level was higher in the EH group than that in the control group(P<0.01),and the urine NGAL level was significantly different among the three groups,and was positively correlated with the severity of UAER. Compared with the NA group,the urine NGAL level significantly increased in the MA group and the CN group. In addition,the urine NGAL level was negatively correlated with the eGFR(r=-0.729,P<0.01),and positively correlated with serum CysC(r=0.773,P<0.01). Conclusion:The level of urine NGAL is significantly higher in patients with essential hypertension and positively correlated with the severity of renal injury. Thus,urine NGAL may become a new indicator for the assessment of early renal injury in essential hypertension.
