CAJ | 학술논문

WNT(wingless-type MMTV integration site family)基因是重要的细胞信号分子，在胚胎发育过程中参与决定细胞命运、细胞增殖、分化、运动及凋亡，其靶基因包括参与细胞发育、细胞增殖及细胞迁移的相关因子，信号转导过程发生异常会导致细胞生长、分化、代谢及生物学异常，引起多种疾病发生。 WNT通路可能参与了子宫发育及维持子宫内膜的功能，与雌激素诱导的子宫内膜增殖有关，本文对WNT信号通路与子宫内膜发育、子宫内膜异位症及子宫内膜癌相关关系的研究进展加以综述。
WNT(wingless-type MMTV integration site family)기인시중요적세포신호분자，재배태발육과정중삼여결정세포명운、세포증식、분화、운동급조망，기파기인포괄삼여세포발육、세포증식급세포천이적상관인자，신호전도과정발생이상회도치세포생장、분화、대사급생물학이상，인기다충질병발생。 WNT통로가능삼여료자궁발육급유지자궁내막적공능，여자격소유도적자궁내막증식유관，본문대WNT신호통로여자궁내막발육、자궁내막이위증급자궁내막암상관관계적연구진전가이종술。
WNT (wingless-type MMTV integration site family) genes are important cell signal molecules, participating in cell fatedecision, cell proliferation, differentiation, movement and apoptosis during embryonic development. The target genes of WNT and the pathway include agents relative to cell growth, proliferation and cell migration. Abnormalities in the signal transduction process will lead to abnormalities in cell growth, differentiation, metabolism, causing many dis-eases. The WNT pathway may be involved in the development and maintenance of uterine endometrial function, in the process of estrogen-induced endometrial proliferation. The research progresses on WNT signaling pathway and endome-trial development, endometriosis and endometrial cancer were reviewed.