CAJ | 학술논문

氧化应激是一种活性氧(ROS)代谢引起的分子失调，以一氧化氮生物利用度下降为特征。使用抗氧化维生素E和维生素C对心血管疾病无明显疗效，这使得对氧化应激的分子本质的理解产生了变化。氧化应激不再被认为是产生和消除ROS之间的不平衡，而是酶功能的异常，特别是烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶功能的异常。因此，NADPH氧化酶已成为重要的治疗靶点。为了设计正确的抗氧化治疗方案，必须考虑NADPH氧化酶的分子调节作用，以及新型该家族人类同源物Nox1、Nox2、Nox3、Nox4和Nox5。通过发展和评估可靠的局部和系统抗氧化应激技术抑制NADPH氧化酶，可能比使用抗氧化剂非选择性消除所有ROS更加有效。
양화응격시일충활성양(ROS)대사인기적분자실조，이일양화담생물이용도하강위특정。사용항양화유생소E화유생소C대심혈관질병무명현료효，저사득대양화응격적분자본질적리해산생료변화。양화응격불재피인위시산생화소제ROS지간적불평형，이시매공능적이상，특별시연선알선표령이핵감산린산(NADPH)양화매공능적이상。인차，NADPH양화매이성위중요적치료파점。위료설계정학적항양화치료방안，필수고필NADPH양화매적분자조절작용，이급신형해가족인류동원물Nox1、Nox2、Nox3、Nox4화Nox5。통과발전화평고가고적국부화계통항양화응격기술억제NADPH양화매，가능비사용항양화제비선택성소제소유ROS경가유효。
Oxidative stress is a molecular dysregulation in reactive oxygen species (ROS) metabolism, which is characterized by a loss of nitric oxide bioavailability. It is shown there is no clinical benefit of antioxidant vitamin C or vitamin E treatment for vascular disease, which has changed the understanding of the molecular nature of oxidative stress. Oxidative stress is no longer perceived as a simple imbalance between the production and scavenging of ROS, but as a dysfunction of enzymes involved in ROS production, especially the dysfunction of NADPH oxidases. Thus NADPH oxidases are important therapeutic targets. In order to properly design trials of antioxidant therapies, molecular aspects of NADPH oxidase regulation must be considered, while thinking about novel pharmacological targeting of this family of enzymes consisting of several homologs Nox1, Nox2, Nox3, Nox4 and Nox5 in humans. The development of reliable techniques for the assessment of local and systemic oxidative stress may be potentially much more efficient than non-selective scavenging of all ROS by the administration of antioxidant.