中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
22期
15-16
,共2页
慢性肾脏病%左心室肥厚%高同型半胱氨酸血症
慢性腎髒病%左心室肥厚%高同型半胱氨痠血癥
만성신장병%좌심실비후%고동형반광안산혈증
Chronic kidney disease%Left ventricular hypertrophy%Hyperhomocystinemia
目的:研究慢性肾脏病(CKD)患者血浆高同型半胱氨酸血症(HHcy)与左心室肥厚(LVH)发生的相关性。方法:回顾性分析本院212例CKD1-5期非透析患者的临床病例,其中血浆高同型半胱氨酸血症组(Hcy group)145例,血浆正常同型半胱氨酸血症组(n-Hcy group)67例,并采用彩色多普勒超声诊断仪测定患者的左心室形态结构。结果:212例CKD1-5期患者中发生左心室肥厚(LVH)者占45.75%,其中血浆高同型半胱氨酸(Hcy)组左心室肥厚发生率为51.03%,血浆正常同型半胱氨酸(Hcy)组左心室肥厚发生率为34.33%,两组比较差异有统计学意义(P<0.01);且血浆Hcy增高组的室间隔厚度(IVST)、左心室后壁厚度(LVPWT)、左心室心肌重量指数(LVMI)均明显高于血浆Hcy正常组,比较差异有统计学意义(P<0.01)。结论:慢性肾脏病患者普遍存在高同型半胱氨酸血症和左心室肥厚,高同型半胱氨酸血症是慢性肾脏病患者发生左心室肥厚的独立危险因素。
目的:研究慢性腎髒病(CKD)患者血漿高同型半胱氨痠血癥(HHcy)與左心室肥厚(LVH)髮生的相關性。方法:迴顧性分析本院212例CKD1-5期非透析患者的臨床病例,其中血漿高同型半胱氨痠血癥組(Hcy group)145例,血漿正常同型半胱氨痠血癥組(n-Hcy group)67例,併採用綵色多普勒超聲診斷儀測定患者的左心室形態結構。結果:212例CKD1-5期患者中髮生左心室肥厚(LVH)者佔45.75%,其中血漿高同型半胱氨痠(Hcy)組左心室肥厚髮生率為51.03%,血漿正常同型半胱氨痠(Hcy)組左心室肥厚髮生率為34.33%,兩組比較差異有統計學意義(P<0.01);且血漿Hcy增高組的室間隔厚度(IVST)、左心室後壁厚度(LVPWT)、左心室心肌重量指數(LVMI)均明顯高于血漿Hcy正常組,比較差異有統計學意義(P<0.01)。結論:慢性腎髒病患者普遍存在高同型半胱氨痠血癥和左心室肥厚,高同型半胱氨痠血癥是慢性腎髒病患者髮生左心室肥厚的獨立危險因素。
목적:연구만성신장병(CKD)환자혈장고동형반광안산혈증(HHcy)여좌심실비후(LVH)발생적상관성。방법:회고성분석본원212례CKD1-5기비투석환자적림상병례,기중혈장고동형반광안산혈증조(Hcy group)145례,혈장정상동형반광안산혈증조(n-Hcy group)67례,병채용채색다보륵초성진단의측정환자적좌심실형태결구。결과:212례CKD1-5기환자중발생좌심실비후(LVH)자점45.75%,기중혈장고동형반광안산(Hcy)조좌심실비후발생솔위51.03%,혈장정상동형반광안산(Hcy)조좌심실비후발생솔위34.33%,량조비교차이유통계학의의(P<0.01);차혈장Hcy증고조적실간격후도(IVST)、좌심실후벽후도(LVPWT)、좌심실심기중량지수(LVMI)균명현고우혈장Hcy정상조,비교차이유통계학의의(P<0.01)。결론:만성신장병환자보편존재고동형반광안산혈증화좌심실비후,고동형반광안산혈증시만성신장병환자발생좌심실비후적독립위험인소。
Objective:To study the the relationship between hyperhomocysteinemia and left ventricular hypertrophy in patients with chronic kidney disease. Method:Clinical 212 CKD1-5 non-dialysis patients were analyzed. The serum Hyperhomocystinemia Group(Hcy group)included 145 cases and the serum normal-hyperhomocystinemia Group(n-Hcy group)67 cases. To estimate the ventricular morphology with color doppler ultrasonic diagnostic instrument. Result:45.75%patients had left ventricular hypertrophy(LVH)on the 212 CKD1-5 non-dialysis patients. The probability of the Hcy group was 51.03%,and the n-Hcy group was 34.33%,which was lower than that of the Hcy group(P<0.01). And the level of the interventricular septum thickness(IVST),left ventricular posteriorwall thickness(LVPWT),and left ventricular mass index (LVMI)of the Hcy group was higher than that of the n-Hcy group(P<0.01). Conclusion:Patients with chronic kidney disease is prevalent hyperhomocysteinemia and left ventricular hypertrophy. Hyperhomocysteinemia is an independent risk factor for left ventricular hypertrophy in chronic kidney disease patients.