中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
22期
105-108
,共4页
朱红%王新%蔡云亮%李安学%李文兵%黄静%郑自群
硃紅%王新%蔡雲亮%李安學%李文兵%黃靜%鄭自群
주홍%왕신%채운량%리안학%리문병%황정%정자군
七氟醚%麻醉深度%老年患者%术后认知功能障碍%S100β
七氟醚%痳醉深度%老年患者%術後認知功能障礙%S100β
칠불미%마취심도%노년환자%술후인지공능장애%S100β
Sevofluence%Depth of anesthesia%Elderly patients%Postoperative cognitive dysfunction%S100β
目的:观察七氟醚在两种不同麻醉深度下对老年腹腔镜手术患者早期术后认知功能的影响。方法选择2013年5月~2014年10月深圳市龙岗区人民医院行腹部腹腔镜手术患者120例,采用随机数字表法将其分为麻醉较深组(Ⅰ组)和麻醉较浅组(Ⅱ组),每组60例。两组患者均选择全身麻醉,术中吸入七氟醚维持麻醉,Ⅰ组维持BIS值35~45,Ⅱ组维持BIS值50~60,其余麻醉处理相同。采用简易精神状态评价量表(MMSE)于术前1 d、术后1、3、7 d对患者进行精神状态评分;手术前、后分别采集静脉血样,采用酶联免疫吸附法检测血清S100β蛋白水平。结果两组患者麻醉手术前MMSE评分差异无统计学意义(P>0.05);两组患者术后1、3 d MMSE评分均较麻醉前明显下降(P<0.01),且Ⅱ组MMSE评分明显低于Ⅰ组(P<0.05);两组患者术后7 d MMSE评分均恢复到麻醉前水平(P>0.05),Ⅱ组MMSE评分低于Ⅰ组,但差异无统计学意义(P>0.05)。Ⅰ组和Ⅱ组术后POCD的发生率比较[术后1 d:28.3%比36.7%;术后3 d:1.7%比21.7%;术后7d:1.7%比0.0%],差异均无统计学意义(P>0.05)。术前两组血清S100β蛋白浓度差异无统计学意义(P>0.05)。术后1 d两组血清S100β蛋白浓度的均较麻醉前1 d明显升高(P<0.05),且Ⅱ组血清S100β蛋白浓度明显高于Ⅰ组(P<0.05);两组患者术后3、7 d血清S100β蛋白浓度均恢复到麻醉前水平(P>0.05),两组血清S100β蛋白浓度比较,差异无统计学意义(P>0.05)。结论七氟醚吸入麻醉中,与较浅麻醉(BIS值50~60)比较,较深麻醉(BIS值35~45)可减少老年患者术后早期MMSE评分下降、抑制血清S100β蛋白水平升高,对老年腹腔镜手术患者早期术后认知功能的影响较小。
目的:觀察七氟醚在兩種不同痳醉深度下對老年腹腔鏡手術患者早期術後認知功能的影響。方法選擇2013年5月~2014年10月深圳市龍崗區人民醫院行腹部腹腔鏡手術患者120例,採用隨機數字錶法將其分為痳醉較深組(Ⅰ組)和痳醉較淺組(Ⅱ組),每組60例。兩組患者均選擇全身痳醉,術中吸入七氟醚維持痳醉,Ⅰ組維持BIS值35~45,Ⅱ組維持BIS值50~60,其餘痳醉處理相同。採用簡易精神狀態評價量錶(MMSE)于術前1 d、術後1、3、7 d對患者進行精神狀態評分;手術前、後分彆採集靜脈血樣,採用酶聯免疫吸附法檢測血清S100β蛋白水平。結果兩組患者痳醉手術前MMSE評分差異無統計學意義(P>0.05);兩組患者術後1、3 d MMSE評分均較痳醉前明顯下降(P<0.01),且Ⅱ組MMSE評分明顯低于Ⅰ組(P<0.05);兩組患者術後7 d MMSE評分均恢複到痳醉前水平(P>0.05),Ⅱ組MMSE評分低于Ⅰ組,但差異無統計學意義(P>0.05)。Ⅰ組和Ⅱ組術後POCD的髮生率比較[術後1 d:28.3%比36.7%;術後3 d:1.7%比21.7%;術後7d:1.7%比0.0%],差異均無統計學意義(P>0.05)。術前兩組血清S100β蛋白濃度差異無統計學意義(P>0.05)。術後1 d兩組血清S100β蛋白濃度的均較痳醉前1 d明顯升高(P<0.05),且Ⅱ組血清S100β蛋白濃度明顯高于Ⅰ組(P<0.05);兩組患者術後3、7 d血清S100β蛋白濃度均恢複到痳醉前水平(P>0.05),兩組血清S100β蛋白濃度比較,差異無統計學意義(P>0.05)。結論七氟醚吸入痳醉中,與較淺痳醉(BIS值50~60)比較,較深痳醉(BIS值35~45)可減少老年患者術後早期MMSE評分下降、抑製血清S100β蛋白水平升高,對老年腹腔鏡手術患者早期術後認知功能的影響較小。
목적:관찰칠불미재량충불동마취심도하대노년복강경수술환자조기술후인지공능적영향。방법선택2013년5월~2014년10월심수시룡강구인민의원행복부복강경수술환자120례,채용수궤수자표법장기분위마취교심조(Ⅰ조)화마취교천조(Ⅱ조),매조60례。량조환자균선택전신마취,술중흡입칠불미유지마취,Ⅰ조유지BIS치35~45,Ⅱ조유지BIS치50~60,기여마취처리상동。채용간역정신상태평개량표(MMSE)우술전1 d、술후1、3、7 d대환자진행정신상태평분;수술전、후분별채집정맥혈양,채용매련면역흡부법검측혈청S100β단백수평。결과량조환자마취수술전MMSE평분차이무통계학의의(P>0.05);량조환자술후1、3 d MMSE평분균교마취전명현하강(P<0.01),차Ⅱ조MMSE평분명현저우Ⅰ조(P<0.05);량조환자술후7 d MMSE평분균회복도마취전수평(P>0.05),Ⅱ조MMSE평분저우Ⅰ조,단차이무통계학의의(P>0.05)。Ⅰ조화Ⅱ조술후POCD적발생솔비교[술후1 d:28.3%비36.7%;술후3 d:1.7%비21.7%;술후7d:1.7%비0.0%],차이균무통계학의의(P>0.05)。술전량조혈청S100β단백농도차이무통계학의의(P>0.05)。술후1 d량조혈청S100β단백농도적균교마취전1 d명현승고(P<0.05),차Ⅱ조혈청S100β단백농도명현고우Ⅰ조(P<0.05);량조환자술후3、7 d혈청S100β단백농도균회복도마취전수평(P>0.05),량조혈청S100β단백농도비교,차이무통계학의의(P>0.05)。결론칠불미흡입마취중,여교천마취(BIS치50~60)비교,교심마취(BIS치35~45)가감소노년환자술후조기MMSE평분하강、억제혈청S100β단백수평승고,대노년복강경수술환자조기술후인지공능적영향교소。
Objective To investigate deferent depth of Sevofluence anesthesia on postoperative cognitive function (POCD) in elderly patients after early laparoscopic surgery. Methods From May 2013 to October 2014, in Shenzhen Longgang District People's Hospital, 120 elderly patients undergoing abdominal laparoscopic surgery were randomly di-vided into deeper anesthesia group (group Ⅰ) and shallow group (groupII) according random number table, with 60 cases in each group. All patients were given general anesthesia maintained with Sevofluence, and group Ⅰ maintained BIS value at 35-45 and groupII at 50-60. The rest anaesthesia managements were similar. In the preoperative and postoperative the mini mental state examination (MMSE) was evaluated for all patients and blood samples were collect-ed to determine the concentration of serum S100βprotein by ELISA. Results MMSE scores were not statistically signif-icant in two groups before surgery (P> 0.05). In the 1 d and 3 d after surgery MMSE scores in two groups decreased significantly compared with preoperative (P< 0.01), and the decline was significantly lower in group II than groupⅠ(P<0.05). The incidences of POCD in groupⅠ and groupII [1 d postoperative: 28.3% v s 36.7%; 3 d postoperative:1.7% v s 21.7%; 7d postoperative: 1.7% v s 0.0%] had no statistically significant difference (P> 0.05). Before surgery there was no statistically significant between the two groups in the concentration of S100β protein (P> 0.05). In 1 d postoperative it was significantly higher in both groups than 1 d preoperative (P>0.05), and group II increased signifi-cantly higher than group Ⅰ (P< 0.05). Conclusion In Sevofluence inhalation anesthesia deeper anesthesia (BIS value of 35-45) can reduce MMSE score, decreases and suppresses the elevation of concentration of S100β protein, and less impact on early postoperative cognitive function in elderly patients with laparoscopic surgery.