CAJ | 학술논문

目的：研究戊型肝炎的流行病学及临床特征，为其防治积累经验。方法回顾性分析2011年1月至2013年12月在本院住院治疗的98例戊型肝炎患者的流行病学及临床特征。结果本组病例年龄为9～79岁，以青壮年（20～50岁）多见（62/98，占63.27%），且男性多于女性（1.88∶1），全年均可发病，多见于无业及退休居民、工人及农民（82/98，占83.67%），部分患者合并基础疾病（24/98，占24.49%）。检查提示氨基转移酶及胆红素明显升高，病原学检查示抗-HEV-IgM及抗-HEV-IgG双阳性多见（48/98，48.98%）。经治疗后，治愈71例（71.45%），好转25例（25.51%），死亡2例（2.04%）。有1例老年女性患者迁延不愈，病程已达1年。结论戊型肝炎发病与年龄、性别、职业及有无基础疾病有关，经过早隔离、早治疗后，预后较好，但同时需警惕戊型肝炎的慢性化进程。
목적：연구무형간염적류행병학급림상특정，위기방치적루경험。방법회고성분석2011년1월지2013년12월재본원주원치료적98례무형간염환자적류행병학급림상특정。결과본조병례년령위9～79세，이청장년（20～50세）다견（62/98，점63.27%），차남성다우녀성（1.88∶1），전년균가발병，다견우무업급퇴휴거민、공인급농민（82/98，점83.67%），부분환자합병기출질병（24/98，점24.49%）。검사제시안기전이매급담홍소명현승고，병원학검사시항-HEV-IgM급항-HEV-IgG쌍양성다견（48/98，48.98%）。경치료후，치유71례（71.45%），호전25례（25.51%），사망2례（2.04%）。유1례노년녀성환자천연불유，병정이체1년。결론무형간염발병여년령、성별、직업급유무기출질병유관，경과조격리、조치료후，예후교호，단동시수경척무형간염적만성화진정。
ObjectiveTo investigate the epidemiological and clinical characteristics of patients infected with hepatitis E virus (HEV) in Chengdu from 2011 to 2013.Methods A retrospective analysis was conducted to investigate 98 patients with HEV infection in our hospital from January 2011 to December 2013 in terms of epidemiological and clinical characteristics.ResultsAmong the 98 patients aged 9 years to 79 years, 63.27% of the cases were young adults (20-50 years old), and male patients numbered more than female ones (1.88∶1). Hepatitis E virus infectionoccurred throughout the year. The most patients were unemployed or retired residents, workers and peasants, and some were with basic diseases. Examination showed signiifcantly increased level of serum transaminase and bilirubin. After pathogen identified by pharyngeal swab, anti-HEV-IgM and anti-HEV-IgG double-positive was confirmed in 48 patients. After treatment, 71 patients (71.45%) were cured, 25 patients (25.51%) were improved, and 2 patients died (2.04%).There was an old female patient deferred longer than one year.ConclusionsThe incidence of HEV is related to age, season, profession and basic diseases. Except for few chronicity, early insulation and effective treatment measures may lead to favourable prognosis.