中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2015年
7期
491-496
,共6页
田莉%李绍梅%闫喆%于连英%贾瑞丽%唐冰瑶
田莉%李紹梅%閆喆%于連英%賈瑞麗%唐冰瑤
전리%리소매%염철%우련영%가서려%당빙요
心血管疾病%心室功能,左%慢性肾脏病%胎盘生长因子
心血管疾病%心室功能,左%慢性腎髒病%胎盤生長因子
심혈관질병%심실공능,좌%만성신장병%태반생장인자
Cardiovascular diseases%Ventricular function,left%Chronic kidney disease%Placental growth factor
目的 探讨慢性肾脏病(CKD)患者血清胎盘生长因子(placental growth factor,PLGF)水平及其与左心室结构和功能的关系.方法 选取CKD非透析患者72例,年龄、性别相匹配的健康体检者16例作为对照组.采用酶联免疫吸附法测定血清PLGF浓度,心脏超声评定心脏形态和结构.结果 (1)CKD患者血清PLGF显著高于对照组[3.32(2.97,19.77) ng/L比2.33 (2.27,2.49) ng/L,P＜0.01];且随着肾功能的减退,PLGF水平进行性升高(P＜ 0.05/6).(2)CKD各期患者的室间隔厚度(IVST)和左室后壁厚度(LVPWT)升高,射血分数(EF)下降.(3)CKD患者左心室肥厚组血清PLGF显著高于非左心室肥厚组[19.05 (3.31,21.05) ng/L比2.99 (2.60,3.32) ng/L,P＜0.05].PLGF高浓度组左室肥厚发生率显著高于PLGF低浓度组(70％比18％,P＜ 0.01).(4)相关分析显示PLGF与左心室质量指数、收缩压、舒张压、24 h尿蛋白、血肌酐(Scr)、血尿酸(UA)、血尿素氮(BUN)、甲状旁腺激素(iPTH)、高血压病史呈正相关(P＜0.05),与左心室射血分数、血红蛋白(Hb)、血白蛋白(Alb)、肾小球滤过率(eGFR)呈负相关(P＜0.01).多元线性逐步回归分析显示,血肌酐、血红蛋白、射血分数、血尿酸是PLGF的独立相关因素(P＜0.05).结论 CKD患者血清PLGF显著升高,PLGF与CKD患者心脏结构和功能改变密切相关,其可能参与CKD患者心血管事件的发生.
目的 探討慢性腎髒病(CKD)患者血清胎盤生長因子(placental growth factor,PLGF)水平及其與左心室結構和功能的關繫.方法 選取CKD非透析患者72例,年齡、性彆相匹配的健康體檢者16例作為對照組.採用酶聯免疫吸附法測定血清PLGF濃度,心髒超聲評定心髒形態和結構.結果 (1)CKD患者血清PLGF顯著高于對照組[3.32(2.97,19.77) ng/L比2.33 (2.27,2.49) ng/L,P＜0.01];且隨著腎功能的減退,PLGF水平進行性升高(P＜ 0.05/6).(2)CKD各期患者的室間隔厚度(IVST)和左室後壁厚度(LVPWT)升高,射血分數(EF)下降.(3)CKD患者左心室肥厚組血清PLGF顯著高于非左心室肥厚組[19.05 (3.31,21.05) ng/L比2.99 (2.60,3.32) ng/L,P＜0.05].PLGF高濃度組左室肥厚髮生率顯著高于PLGF低濃度組(70％比18％,P＜ 0.01).(4)相關分析顯示PLGF與左心室質量指數、收縮壓、舒張壓、24 h尿蛋白、血肌酐(Scr)、血尿痠(UA)、血尿素氮(BUN)、甲狀徬腺激素(iPTH)、高血壓病史呈正相關(P＜0.05),與左心室射血分數、血紅蛋白(Hb)、血白蛋白(Alb)、腎小毬濾過率(eGFR)呈負相關(P＜0.01).多元線性逐步迴歸分析顯示,血肌酐、血紅蛋白、射血分數、血尿痠是PLGF的獨立相關因素(P＜0.05).結論 CKD患者血清PLGF顯著升高,PLGF與CKD患者心髒結構和功能改變密切相關,其可能參與CKD患者心血管事件的髮生.
목적 탐토만성신장병(CKD)환자혈청태반생장인자(placental growth factor,PLGF)수평급기여좌심실결구화공능적관계.방법 선취CKD비투석환자72례,년령、성별상필배적건강체검자16례작위대조조.채용매련면역흡부법측정혈청PLGF농도,심장초성평정심장형태화결구.결과 (1)CKD환자혈청PLGF현저고우대조조[3.32(2.97,19.77) ng/L비2.33 (2.27,2.49) ng/L,P＜0.01];차수착신공능적감퇴,PLGF수평진행성승고(P＜ 0.05/6).(2)CKD각기환자적실간격후도(IVST)화좌실후벽후도(LVPWT)승고,사혈분수(EF)하강.(3)CKD환자좌심실비후조혈청PLGF현저고우비좌심실비후조[19.05 (3.31,21.05) ng/L비2.99 (2.60,3.32) ng/L,P＜0.05].PLGF고농도조좌실비후발생솔현저고우PLGF저농도조(70％비18％,P＜ 0.01).(4)상관분석현시PLGF여좌심실질량지수、수축압、서장압、24 h뇨단백、혈기항(Scr)、혈뇨산(UA)、혈뇨소담(BUN)、갑상방선격소(iPTH)、고혈압병사정정상관(P＜0.05),여좌심실사혈분수、혈홍단백(Hb)、혈백단백(Alb)、신소구려과솔(eGFR)정부상관(P＜0.01).다원선성축보회귀분석현시,혈기항、혈홍단백、사혈분수、혈뇨산시PLGF적독립상관인소(P＜0.05).결론 CKD환자혈청PLGF현저승고,PLGF여CKD환자심장결구화공능개변밀절상관,기가능삼여CKD환자심혈관사건적발생.
Objective To investigate the serum level of placental growth factor (PLGF) and explore its relationship with left ventricular structure and function in chronic kidney disease (CKD) patients.Methods Seventy-two non-dialysis CKD patients and sixteen age-and sex-matched healthy controls were included in this study.Serum PLGF level was measured by ELISA.Cardiac structure and function were assessed by two dimensional echocardiography.Results (1)The serum level of PLGF in CKD patients[3.32(2.97,19.77) ng/L] was significantly higher compared to the healthy controls [2.33(2.27,2.49) ng/L] (P ＜ 0.01).It progressively increased with the decline of renal function (P＜ 0.05/6).(2)The interventricular septum (IVS),left ventricular posterior wall (LVPW) was significantly higher while the ejection fraction was significantly lower in CKD patients.(3)The serum PLGF level was higher in patients with left ventricular hypertrophy (LVH) than those without LVH [19.05(3.31,21.05) ng/L vs 2.99(2.60,3.32) ng/L,P ＜ 0.05].The prevalence of LVH in the group above median PLGF level was significantly higher than that in the group below the median PLGF level (70％ vs 18％,P ＜ 0.01).(4)PLGF level was positively correlated with left ventricular mass index (LVMI),systolic pressure,diastolic pressure,24 h urine protein,Scr,UA,BUN,iPTH,the history of high blood pressure and was negatively correlated with LVEF,hemoglobin,albumin,eGFR (P ＜ 0.05).Multiple regression results showed that UA,Scr,LVEF,Hb were associated with PLGF level independently (P ＜ 0.01).Conclusions CKD patients have elevated level of PLGF.It has a relationship with cardiac structure and function.It may participate in the occurrence of cardiovascular events.
