中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2015年
8期
687-690
,共4页
经颅磁刺激%额叶前皮质%认知%执行功能%脑损害,慢性
經顱磁刺激%額葉前皮質%認知%執行功能%腦損害,慢性
경로자자격%액협전피질%인지%집행공능%뇌손해,만성
Transcranial magnetic stimulation%Prefrontal cortex%Cognition%Executive function%Brain damage,chronic
目的 探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对前额叶损伤患者认知功能的影响.方法 选取安徽医科大学附属安庆医院神经外科和神经内科2012年1月至2014年10月住院的21例前额叶损伤的患者,对所有受试者均予常规治疗作为背景治疗.同时给予rTMS治疗,分别于治疗前、后进行事件相关电位P300检查和蒙特利尔认知评估量表(MoCA)评分.结果 与治疗前比较,rTMS治疗后P300潜伏期[分别为(367.38±9.79)、(345.43±11.31)ms]明显缩短(t=5.33,P＜0.05)、波幅[分别为(4.79±1.02)、(7.84±1.40) μV]明显增高(t=-8.08,P＜0.05),MoCA总分[分别为(19.57±2.06)、(23.91±1.30)分]、记忆测试得分[分别为(2.19±0.81)、(4.10±0.89)分]和执行能力[分别为(2.52±1.08)、(3.57±0.93)分]明显增高(t=-8.14、-7.24、-3.38,均P＜0.05);且左、右侧额叶损伤的患者治疗前的MoCA总分[分别为(18.22±1.56)、(20.58±1.83)分]、记忆测试得分[分别为(1.89±0.78)、(2.42±0.79)分]和执行能力[分别为(1.56±0.53)、(3.25±0.75)分]差异有统计学意义(t=-3.11、-2.26、-5.76,均P＜0.05),其余各项测试左右侧差异无统计学意义(P＞0.05).结论 rTMS能改善前额叶损伤患者认知功能,且是安全的.
目的 探討重複經顱磁刺激(repetitive transcranial magnetic stimulation,rTMS)對前額葉損傷患者認知功能的影響.方法 選取安徽醫科大學附屬安慶醫院神經外科和神經內科2012年1月至2014年10月住院的21例前額葉損傷的患者,對所有受試者均予常規治療作為揹景治療.同時給予rTMS治療,分彆于治療前、後進行事件相關電位P300檢查和矇特利爾認知評估量錶(MoCA)評分.結果 與治療前比較,rTMS治療後P300潛伏期[分彆為(367.38±9.79)、(345.43±11.31)ms]明顯縮短(t=5.33,P＜0.05)、波幅[分彆為(4.79±1.02)、(7.84±1.40) μV]明顯增高(t=-8.08,P＜0.05),MoCA總分[分彆為(19.57±2.06)、(23.91±1.30)分]、記憶測試得分[分彆為(2.19±0.81)、(4.10±0.89)分]和執行能力[分彆為(2.52±1.08)、(3.57±0.93)分]明顯增高(t=-8.14、-7.24、-3.38,均P＜0.05);且左、右側額葉損傷的患者治療前的MoCA總分[分彆為(18.22±1.56)、(20.58±1.83)分]、記憶測試得分[分彆為(1.89±0.78)、(2.42±0.79)分]和執行能力[分彆為(1.56±0.53)、(3.25±0.75)分]差異有統計學意義(t=-3.11、-2.26、-5.76,均P＜0.05),其餘各項測試左右側差異無統計學意義(P＞0.05).結論 rTMS能改善前額葉損傷患者認知功能,且是安全的.
목적 탐토중복경로자자격(repetitive transcranial magnetic stimulation,rTMS)대전액협손상환자인지공능적영향.방법 선취안휘의과대학부속안경의원신경외과화신경내과2012년1월지2014년10월주원적21례전액협손상적환자,대소유수시자균여상규치료작위배경치료.동시급여rTMS치료,분별우치료전、후진행사건상관전위P300검사화몽특리이인지평고량표(MoCA)평분.결과 여치료전비교,rTMS치료후P300잠복기[분별위(367.38±9.79)、(345.43±11.31)ms]명현축단(t=5.33,P＜0.05)、파폭[분별위(4.79±1.02)、(7.84±1.40) μV]명현증고(t=-8.08,P＜0.05),MoCA총분[분별위(19.57±2.06)、(23.91±1.30)분]、기억측시득분[분별위(2.19±0.81)、(4.10±0.89)분]화집행능력[분별위(2.52±1.08)、(3.57±0.93)분]명현증고(t=-8.14、-7.24、-3.38,균P＜0.05);차좌、우측액협손상적환자치료전적MoCA총분[분별위(18.22±1.56)、(20.58±1.83)분]、기억측시득분[분별위(1.89±0.78)、(2.42±0.79)분]화집행능력[분별위(1.56±0.53)、(3.25±0.75)분]차이유통계학의의(t=-3.11、-2.26、-5.76,균P＜0.05),기여각항측시좌우측차이무통계학의의(P＞0.05).결론 rTMS능개선전액협손상환자인지공능,차시안전적.
Objective To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function and safety in patients with lesions in prefrontal cortex (PFC).Methods Twenty-one patients with lesions in PFC hospitalized in the Department of Neurosurgery and Department of Neurology,Anqing Hospital Affiliated to Anhui Medical University between January 2012 and October 2014 were enrolled and given regular drug treatment as a background.Event-related potential (ERP) P300 latency and amplitude,Montreal Cognitive Assessment (MoCA) scores were recorded and compared before and after 4-week rTMS treatment.Results Compared with those before rTMS treatment,P300 latency ((367.38 ± 9.79) ms vs (345.43 ± 11.31) ms;t =5.33,P ＜ 0.05) was significantly shortened,while amplitude ((4.79 ± 1.02) μV vs (7.84 ± 1.40) μV;t =-8.08,P ＜ 0.05),MoCA scores (19.57 ±2.06 vs 23.91 ± 1.30;t =-8.14,P ＜ 0.05),memory test scores (2.19 ± 0.81 vs 4.10 ± 0.89;t =-7.24,P ＜ 0.05) and executive function test scores (2.52 ± 1.08 vs 3.57 ± 0.93;t =-3.38,P ＜0.05) were obviously increased.MoCA scores (18.22 ± 1.56 vs 20.58 ± 1.83;t =-3.11,P ＜ 0.05),memory test scores (1.89 ± 0.78 vs 2.42 ± 0.79;t =-2.26,P ＜ 0.05) and executive function test scores (1.56 ± 0.53 vs 3.25 ± 0.75;t =-5.76,P ＜ 0.05) showed statistically significant difference before rTMS treatment in patients with lesions in either right or left front lobe.Conclusions rTMS which is thought to be a safe procedure can improve cognitive function in patients with lesions in prefrontal cortex.
