中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
5期
461-463
,共3页
妊娠期糖尿病%甲状腺功能%自身抗体
妊娠期糖尿病%甲狀腺功能%自身抗體
임신기당뇨병%갑상선공능%자신항체
Gestational diabetes%Thyroid function%Autoantibodies
目的 探讨妊娠期糖尿病(GDM)高危孕妇孕早期甲状腺功能筛查的意义.方法 选择存在GDM危险因素的孕妇共194例,经口服糖耐量试验(OGTT)检测分为3组:A组(3项均正常,共109例)、B组(1项异常,共57例)和C组(2项及以上异常,共28例),在早孕期检测血清抗甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)、血清三碘甲状腺原氨酸(TT3)、甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺素(TSH),并进行统计学比较.结果 A组TSH水平显著低于B组和C组[(1.45±0.43) mU/L与(1.77±0.53)、(1.89±0.74) mU/L],FT4水平显著高于B组和C组[(11.62±0.98) nmol/L与(10.23±0.75)、(9.87±0.88) nmol/L],差异均有统计学意义(P均＜0.05);A组TPOAb、TGAb阳性比例显著低于B组和C组[9.17％ (10/109)与21.05％ (12/57)、28.57％ (8/28);3.67％ (4/109)与7.02％(5/57)、17.86％ (5/28)],差异有统计学意义(P均＜0.05),TPOAb+TGAb阳性比例也显著低于B组和C组[0.92％(1/109)与7.02％(4/57)、17.86％(5/28)],差异有统计学意义(P均＜0.05).结论 在早孕期对GDM高危孕妇进行甲状腺功能筛查具有重要意义,值得临床推广.
目的 探討妊娠期糖尿病(GDM)高危孕婦孕早期甲狀腺功能篩查的意義.方法 選擇存在GDM危險因素的孕婦共194例,經口服糖耐量試驗(OGTT)檢測分為3組:A組(3項均正常,共109例)、B組(1項異常,共57例)和C組(2項及以上異常,共28例),在早孕期檢測血清抗甲狀腺毬蛋白抗體(TGAb)、抗甲狀腺過氧化物酶抗體(TPOAb)、血清三碘甲狀腺原氨痠(TT3)、甲狀腺素(TT4)、遊離三碘甲狀腺原氨痠(FT3)、遊離甲狀腺素(FT4)和促甲狀腺素(TSH),併進行統計學比較.結果 A組TSH水平顯著低于B組和C組[(1.45±0.43) mU/L與(1.77±0.53)、(1.89±0.74) mU/L],FT4水平顯著高于B組和C組[(11.62±0.98) nmol/L與(10.23±0.75)、(9.87±0.88) nmol/L],差異均有統計學意義(P均＜0.05);A組TPOAb、TGAb暘性比例顯著低于B組和C組[9.17％ (10/109)與21.05％ (12/57)、28.57％ (8/28);3.67％ (4/109)與7.02％(5/57)、17.86％ (5/28)],差異有統計學意義(P均＜0.05),TPOAb+TGAb暘性比例也顯著低于B組和C組[0.92％(1/109)與7.02％(4/57)、17.86％(5/28)],差異有統計學意義(P均＜0.05).結論 在早孕期對GDM高危孕婦進行甲狀腺功能篩查具有重要意義,值得臨床推廣.
목적 탐토임신기당뇨병(GDM)고위잉부잉조기갑상선공능사사적의의.방법 선택존재GDM위험인소적잉부공194례,경구복당내량시험(OGTT)검측분위3조:A조(3항균정상,공109례)、B조(1항이상,공57례)화C조(2항급이상이상,공28례),재조잉기검측혈청항갑상선구단백항체(TGAb)、항갑상선과양화물매항체(TPOAb)、혈청삼전갑상선원안산(TT3)、갑상선소(TT4)、유리삼전갑상선원안산(FT3)、유리갑상선소(FT4)화촉갑상선소(TSH),병진행통계학비교.결과 A조TSH수평현저저우B조화C조[(1.45±0.43) mU/L여(1.77±0.53)、(1.89±0.74) mU/L],FT4수평현저고우B조화C조[(11.62±0.98) nmol/L여(10.23±0.75)、(9.87±0.88) nmol/L],차이균유통계학의의(P균＜0.05);A조TPOAb、TGAb양성비례현저저우B조화C조[9.17％ (10/109)여21.05％ (12/57)、28.57％ (8/28);3.67％ (4/109)여7.02％(5/57)、17.86％ (5/28)],차이유통계학의의(P균＜0.05),TPOAb+TGAb양성비례야현저저우B조화C조[0.92％(1/109)여7.02％(4/57)、17.86％(5/28)],차이유통계학의의(P균＜0.05).결론 재조잉기대GDM고위잉부진행갑상선공능사사구유중요의의,치득림상추엄.
Objective To investigate the significance of thyroid function screening in high-risk pregnant women with gestational diabetes (GDM) in early pregnancy.Methods A total of 194 cases with GDM were selected as our subjects.The patients were divided into group A(three normal items,a total of 109 cases),group B (one abnormal item,a total of 57 cases) and group C (two abnormal items,a total of 28 cases).The levels of serum anti-thyroglobulin antibody (TGAb),anti-thyroid peroxidase antibody (TPOAb),serum three triiodothyronine(TT3),thyroxine (TT4),free three triiodothyronine (FT3),free thyroxine (FT4) and thyroidstimulating hormone (TSH) were screened.Results TSH levels in group A was (1.45 ± 0.43) mU/L,significantly lower than in group B and group C((1.77±0.53),(1.89±0.74) mU/L).FT4 levels in group A was (11.62±0.98) nmol/L,significantly higher in group B and group C((10.23±0.75),(9.87±0.88) nmol/L)).Proportion of TPOAb,TGAb positive in group A were 9.17％(10/109) and 21.05％(12/57),significantly lower than that of group B and group C((28.57％(8/28) and 3.67％(4/109),7.02％(5/57) and 17.86％(5/28)).And the differences were significant (P＜ 0.05).And TPOAb + TGAb in group A was 0.92％(1/109),significantly lower than that of group B and group C(7.02％ (4/57),17.86％ (5/28);P ＜0.05).Conclusion The importance of screening thyroid function in early pregnancy in women at high risk for gestational diabetes is worthy of clinical promotion.
