中国肝脏病杂志（电子版）
中國肝髒病雜誌（電子版）
중국간장병잡지（전자판）
CHINESE JOURNAL OF LIVER DISEASES(ELECTRONIC VERSION)
2015年
2期
72-76
,共5页
解宝江%李振华%袁海峰%刘祝彤%张雪莲
解寶江%李振華%袁海峰%劉祝彤%張雪蓮
해보강%리진화%원해봉%류축동%장설련
肝细胞癌%25-羟基维生素D%酶联免疫吸附法
肝細胞癌%25-羥基維生素D%酶聯免疫吸附法
간세포암%25-간기유생소D%매련면역흡부법
Hepatocellular carcinoma%25-hydroxyvitamin D%ELISA
目的：检测HCC患者外周血25-羟基维生素D[25（OH）D]的水平，探讨测定HCC患者外周血25（OH）D水平的临床意义。方法收集本院住院的HCC患者65例，同时选取年龄、性别与之相匹配的78例健康志愿者作为对照组。采用酶联免疫吸附法（ELISA）测定HCC患者及健康志愿者的外周血25（OH）D水平，并对测定结果及HCC不同TNM分期患者之间的外周血25（OH）D水平分别进行统计学分析。结果 HCC患者的外周血25（OH）D水平[（28.132±10.82）nmol/L]显著低于健康志愿者[（45.635±9.23）nmol/L]（P =0.000）；不同TNM分期的HCC患者之间的外周血25（OH）D水平无显著性差异（P =0.122）。结论上述研究表明，HCC患者的外周血25-羟基维生素D水平较健康志愿者明显降低，提示外周血25（OH）D水平降低与HCC的发生发展可能存在着密切的联系，这对研究HCC的发病机理以及新的诊疗方法有一定指导意义。
目的：檢測HCC患者外週血25-羥基維生素D[25（OH）D]的水平，探討測定HCC患者外週血25（OH）D水平的臨床意義。方法收集本院住院的HCC患者65例，同時選取年齡、性彆與之相匹配的78例健康誌願者作為對照組。採用酶聯免疫吸附法（ELISA）測定HCC患者及健康誌願者的外週血25（OH）D水平，併對測定結果及HCC不同TNM分期患者之間的外週血25（OH）D水平分彆進行統計學分析。結果 HCC患者的外週血25（OH）D水平[（28.132±10.82）nmol/L]顯著低于健康誌願者[（45.635±9.23）nmol/L]（P =0.000）；不同TNM分期的HCC患者之間的外週血25（OH）D水平無顯著性差異（P =0.122）。結論上述研究錶明，HCC患者的外週血25-羥基維生素D水平較健康誌願者明顯降低，提示外週血25（OH）D水平降低與HCC的髮生髮展可能存在著密切的聯繫，這對研究HCC的髮病機理以及新的診療方法有一定指導意義。
목적：검측HCC환자외주혈25-간기유생소D[25（OH）D]적수평，탐토측정HCC환자외주혈25（OH）D수평적림상의의。방법수집본원주원적HCC환자65례，동시선취년령、성별여지상필배적78례건강지원자작위대조조。채용매련면역흡부법（ELISA）측정HCC환자급건강지원자적외주혈25（OH）D수평，병대측정결과급HCC불동TNM분기환자지간적외주혈25（OH）D수평분별진행통계학분석。결과 HCC환자적외주혈25（OH）D수평[（28.132±10.82）nmol/L]현저저우건강지원자[（45.635±9.23）nmol/L]（P =0.000）；불동TNM분기적HCC환자지간적외주혈25（OH）D수평무현저성차이（P =0.122）。결론상술연구표명，HCC환자적외주혈25-간기유생소D수평교건강지원자명현강저，제시외주혈25（OH）D수평강저여HCC적발생발전가능존재착밀절적련계，저대연구HCC적발병궤리이급신적진료방법유일정지도의의。
Objective To investigate the level of 25-hydroxyvitamin D in the peripheral blood of patients with hepatocellular carcinoma and to evaluate its clinical significance.Methods The 65 patients with hepatocellular carcinoma admitted in our hospital and 80 healthy volunteers were recruited, and the levels of 25-hydroxyvitamin D in their peripheral blood samples were detected by enzyme-linked immunosorbent assay (ELISA) method, and the results were statistically analyzed. Besides, the differences of the 25-hydroxyvitamin D levels of the hepatocellular carcinoma patients with different TNM stages were also analyzed simutaneously.ResultsThe 25-hydroxyvitamin D level of the peripheral blood in patients with hepatocellular carcinoma was (28.132 ± 10.82 ) nmol/L, which was signiifcantly lower than that of healthy volunteers [(45.635 ± 9.23 nmol/L,P = 0.000)]; and there were no signiifcant difference among the different TNM staging in patients with hepatocellular carcinoma in peripheral blood of the 25-hydroxyvitamin D, theP value was 0.122.ConclusionsThe present study showed that the 25-hydroxyvitamin D level of the peripheral blood in patients with hepatocellular carcinoma is signiifcantly lower than that of healthy volunteers, which implies that the reduction of the 25-hydroxyvitamin D level in the peripheral blood may closely associated with the occurrence and the development of hepatocellular carcinoma, and this result may be helpful to understand the pathogenesis and ifnd new therapy for hepatocellular carcinoma.
