中国肝脏病杂志（电子版）
中國肝髒病雜誌（電子版）
중국간장병잡지（전자판）
CHINESE JOURNAL OF LIVER DISEASES(ELECTRONIC VERSION)
2015年
2期
33-36
,共4页
王晓娟%梁冬竹%易为%刘敏
王曉娟%樑鼕竹%易為%劉敏
왕효연%량동죽%역위%류민
乙型肝炎病毒%肝硬化%妊娠
乙型肝炎病毒%肝硬化%妊娠
을형간염병독%간경화%임신
Hepatitis B virus%Cirrhosis%Pregnancy
目的：探讨乙型肝炎后肝硬化对女性妊娠结局的影响。方法利用医院电子病历系统回顾性收集在北京地坛医院分娩的乙型肝炎后肝硬化孕妇，按1∶3配对收集同期慢性HBV感染孕妇为对照组，比较2组孕妇孕期及产时各种并发症发生率，以及2组新生儿出生时发育情况。结果共收集肝硬化孕妇25例，均为代偿期肝硬化。肝硬化孕妇中19例孕前使用抗病毒治疗，2例孕中期开始抗病毒治疗。肝硬化组孕妇平均分娩时间（258.92±16.42）天（其中14例在孕37周及以后分娩），产后出血发生率24％，与对照组相比有显著差异（P=0.003，P =0.000）。妊娠期糖尿病、羊水过少、羊水过多、羊水Ⅲ度粪染、妊娠高血压疾病的发生率2组孕妇相比无显著差异（P值均大于0.05）。两组新生儿畸形发生率无明显差异，肝硬化组新生儿窒息发生率12%，与对照组相比有显著差异（P =0.014）。结论代偿期肝硬化患者在抗病毒治疗及密切临床监测下妊娠结局良好，可足月分娩，但应注意产后出血和新生儿窒息的发生。
目的：探討乙型肝炎後肝硬化對女性妊娠結跼的影響。方法利用醫院電子病歷繫統迴顧性收集在北京地罈醫院分娩的乙型肝炎後肝硬化孕婦，按1∶3配對收集同期慢性HBV感染孕婦為對照組，比較2組孕婦孕期及產時各種併髮癥髮生率，以及2組新生兒齣生時髮育情況。結果共收集肝硬化孕婦25例，均為代償期肝硬化。肝硬化孕婦中19例孕前使用抗病毒治療，2例孕中期開始抗病毒治療。肝硬化組孕婦平均分娩時間（258.92±16.42）天（其中14例在孕37週及以後分娩），產後齣血髮生率24％，與對照組相比有顯著差異（P=0.003，P =0.000）。妊娠期糖尿病、羊水過少、羊水過多、羊水Ⅲ度糞染、妊娠高血壓疾病的髮生率2組孕婦相比無顯著差異（P值均大于0.05）。兩組新生兒畸形髮生率無明顯差異，肝硬化組新生兒窒息髮生率12%，與對照組相比有顯著差異（P =0.014）。結論代償期肝硬化患者在抗病毒治療及密切臨床鑑測下妊娠結跼良好，可足月分娩，但應註意產後齣血和新生兒窒息的髮生。
목적：탐토을형간염후간경화대녀성임신결국적영향。방법이용의원전자병력계통회고성수집재북경지단의원분면적을형간염후간경화잉부，안1∶3배대수집동기만성HBV감염잉부위대조조，비교2조잉부잉기급산시각충병발증발생솔，이급2조신생인출생시발육정황。결과공수집간경화잉부25례，균위대상기간경화。간경화잉부중19례잉전사용항병독치료，2례잉중기개시항병독치료。간경화조잉부평균분면시간（258.92±16.42）천（기중14례재잉37주급이후분면），산후출혈발생솔24％，여대조조상비유현저차이（P=0.003，P =0.000）。임신기당뇨병、양수과소、양수과다、양수Ⅲ도분염、임신고혈압질병적발생솔2조잉부상비무현저차이（P치균대우0.05）。량조신생인기형발생솔무명현차이，간경화조신생인질식발생솔12%，여대조조상비유현저차이（P =0.014）。결론대상기간경화환자재항병독치료급밀절림상감측하임신결국량호，가족월분면，단응주의산후출혈화신생인질식적발생。
ObjectiveTo discuss the pregnancy outcomes in women with liver cirrhosis after hepatitis B. Methods Pregnant women with compensated liver cirrhosis after hepatitis B who delivered in Beijing Ditan Hospital were retrospectively collected through the HIS system. According to 1∶3 pairing, the corresponding period pregnant women with chronic HBV infection were collected as control group. The incidence of complications in pregnancy women of the two groups were compared. The development of the neonatus were compared too.ResultsTotally,25 cases of pregnant women with compensated liver cirrhosis were collected, 19 cases were given antiviral therapy before pregnancy and two cases started antiviral therapy at the second trimester. The average delivery time of women with liver cirrhosis was (258.92 ± 16.42) days (including 14 cases at 37 weeks of pregnancy and after), and the rate of postpartum hemorrhage was 24%, the differences were significant compared with the control group (P = 0.003,P = 0.000). There were no significant differences in the incidence of gestational diabetes mellitus, postpartum hemorrhage, polyhydramnios, oligohydramnios, meconium staining of the amniotic lfuidⅢ degrees and hypertensive disorder in pregnancy (P> 0.05). To the infants, it had no signiifcant difference on the rate of congenital abnormality in the two groups (P> 0.05). The rate of neonate asphyxia was 12% in infants whose mother were with liver cirrhosis, which had signiifcant difference with the control group.Conclusions Under antiviral therapy and closely clinical monitoring, the pregnant outcomes in patients with decompensated cirrhosis is good, some of them can full-term delivery. But we should pay attention to the postpartum hemorrhage and neonatal asphyxia.
