CAJ | 학술논문

目的：研究首都医科大学附属北京地坛医院乙型肝炎肝硬化住院患者的并发症、合并症及死亡的相关危险因素。方法分别回顾性分析本院2008年1月至2010年12月2568例和2011年1月至2014年9月3008例乙型肝炎肝硬化住院患者的相关资料。结果发现乙型肝炎肝硬化并发症发病率最高为原发性肝癌，不同时期比较发现发病率呈上升趋势（P =0.000），其余并发症如腹水、上消化道出血、自发性细菌性腹膜炎、肝性脑病、肝肾综合征发病率呈下降趋势（P =0.000）。2型糖尿病、高血压等合并症发病率前后比较无统计学差异（P =0.399，P =0.089）。除自发性细菌性腹膜炎外，肺部感染是肝硬化住院患者最易发的感染。对不同时期死亡的相关危险因素进行多元回归分析，肝癌、自发性细菌性腹膜炎、肝性脑病、肝肾综合征和上消化道出血均与病死显著相关（P =0.000）。结论原发性肝癌仍然是乙型肝炎肝硬化最常见并发症，也是乙型肝炎肝硬化最主要的病死原因，病死患者均伴发多种并发症。
목적：연구수도의과대학부속북경지단의원을형간염간경화주원환자적병발증、합병증급사망적상관위험인소。방법분별회고성분석본원2008년1월지2010년12월2568례화2011년1월지2014년9월3008례을형간염간경화주원환자적상관자료。결과발현을형간염간경화병발증발병솔최고위원발성간암，불동시기비교발현발병솔정상승추세（P =0.000），기여병발증여복수、상소화도출혈、자발성세균성복막염、간성뇌병、간신종합정발병솔정하강추세（P =0.000）。2형당뇨병、고혈압등합병증발병솔전후비교무통계학차이（P =0.399，P =0.089）。제자발성세균성복막염외，폐부감염시간경화주원환자최역발적감염。대불동시기사망적상관위험인소진행다원회귀분석，간암、자발성세균성복막염、간성뇌병、간신종합정화상소화도출혈균여병사현저상관（P =0.000）。결론원발성간암잉연시을형간염간경화최상견병발증，야시을형간염간경화최주요적병사원인，병사환자균반발다충병발증。
Objcetive To analyze the associated complications and the causes of death of hepatitis B virus related cirrhosis patients.Methods The data of 2568 patients from January 2008 to December 2010 and 3008 patients from January 2011 to September 2014, hospitalized in Beijing Ditan Hospital, Capital Medical University, were retrospective reviewed respectively.ResultsAmong all the hepatitis B virus (HBV) related cirrhosis patients, the highest incidence of complication was primary hepatocellular carcinoma (HCC) and it showed an ascending trend in recent years (P = 0.000). The incidence of other complications, including ascites, spontaneous bacterial peritonitis (SBP), upper gastrointestinal bleeding, hepatic encephalopathy (HE) and hepatorenal syndrome(HRS) were reduced (P = 0.000). No signiifcant difference between the incidence of type 2 diabetes and hypertension (P = 0.399,P = 0.089). Apart from SBP, pneumonia was the most frequent type of infection.Conclusions HCC is still the most common complication and the predominant cause of HBV related cirrhosis. A variety of complications coexist in all death patients.