CAJ | 학술논문

目的：探讨原发性食管小细胞癌的临床特点、治疗方案及预后。方法选取病理证实的20例食管小细胞癌，给予放化疗综合治疗，观察治疗效果、不良反应及预后。结果完全缓解4例，部分缓解13例，无缓解3例，中位生存期为0.5、1、2、3年生存率分别为80%（16例）、40%（8例）、15%（3例）、0（0例）。不良反应主要为骨髓抑制、急性放射性食管炎及消化道反应。结论原发性食管小细胞癌预后差，应采取化疗联合放疗、手术的综合治疗方案。
목적：탐토원발성식관소세포암적림상특점、치료방안급예후。방법선취병리증실적20례식관소세포암，급여방화료종합치료，관찰치료효과、불량반응급예후。결과완전완해4례，부분완해13례，무완해3례，중위생존기위0.5、1、2、3년생존솔분별위80%（16례）、40%（8례）、15%（3례）、0（0례）。불량반응주요위골수억제、급성방사성식관염급소화도반응。결론원발성식관소세포암예후차，응채취화료연합방료、수술적종합치료방안。
Objective To observe and investigate the clinical characteristic,treatment and prog-nosis of primary small cell carcinoma of the esophagus. Methods Twenty esophageal carcinoma patients with pathologic diagnosis of primary small cell carcinoma were selected. Chemotherapy combine with ra-diotherapy were given. The efficacy,safety and prognosis was observed. Results After treatment,4 ca-ses had complete remission,13 cases had partial remission,3 cases had no remission. The Median surviv-al time was 344 days. The 0. 5,1-year,2-year and 3-year survival rate was 80%、40%、15% and 0 . Conclusions Primary small cell carcinoma of esophagus is a highly malignant disease with poor prog-nosis. Chemotherapy combine with radiotherapy and operation is the the first treatment prescription.