CAJ | 학술논문

双阴性T细胞(即DNT细胞)是一种细胞表型为TCR+ CD3+ CD4-CD8-的特殊的调节性T细胞,分为αβT和γδT两群,在调节免疫反应中起着十分重要的作用.既往人们对DNT细胞研究主要局限于自身免疫性疾病和器官移植免疫方面.近年来,DNT细胞的过继免疫治疗作为一种新型的抗肿瘤方法逐渐走进公众的视野.本综述主要对DNT细胞来源分群、抗肿瘤作用及其可能的作用机制进行描述.
쌍음성T세포(즉DNT세포)시일충세포표형위TCR+ CD3+ CD4-CD8-적특수적조절성T세포,분위αβT화γδT량군,재조절면역반응중기착십분중요적작용.기왕인문대DNT세포연구주요국한우자신면역성질병화기관이식면역방면.근년래,DNT세포적과계면역치료작위일충신형적항종류방법축점주진공음적시야.본종술주요대DNT세포래원분군、항종류작용급기가능적작용궤제진행묘술.
Double negative T cells,namely DNT cells,are specific regulatory cells with TCR+ CD3 + CD4-CD8-in cell phenotype,divide into αβ T cell and γδ T cell,play a very important role in regulating immunoreaction.Previous research restricted to the treatment of autoimmune disease and organ transplantation immunity.Recently dnt cells adoptive immunotherapy,as a new anti-tumor method,gradually come into public view.This review mainly focuses on the source of DNT cells,their anti-tumor effect,as well as the possible mechanism.