CAJ | 학술논문

目的：探讨Rho激酶（Rho kinase, ROCK）活性与系统性红斑狼疮（SLE）疾病活动度的相关性。方法采用蛋白质印迹法（Western blot）检测SLE患者和健康受试者的ROCK活性，SLE疾病活动指数2000（SLEDAI-2000，SLEDAI-2K）评分评估SLE患者疾病活动程度，应用SPSS17.0统计软件分析ROCK活性与SLEDAI-2K评分的相关性。结果 SLE疾病轻度、中度及重度活动组患者ROCK活性均明显高于健康受试者，中度和重度活动组患者ROCK活性显著高于轻度活动组；中度活动组与重度活动组患者的ROCK活性相比差异无统计学意义；ROCK活性与SLEDAI-2K评分呈相关性。结论 ROCK活性与SLE疾病活动度相关，可作为一种新的潜在的SLE疾病活动度评估指标。
목적：탐토Rho격매（Rho kinase, ROCK）활성여계통성홍반랑창（SLE）질병활동도적상관성。방법채용단백질인적법（Western blot）검측SLE환자화건강수시자적ROCK활성，SLE질병활동지수2000（SLEDAI-2000，SLEDAI-2K）평분평고SLE환자질병활동정도，응용SPSS17.0통계연건분석ROCK활성여SLEDAI-2K평분적상관성。결과 SLE질병경도、중도급중도활동조환자ROCK활성균명현고우건강수시자，중도화중도활동조환자ROCK활성현저고우경도활동조；중도활동조여중도활동조환자적ROCK활성상비차이무통계학의의；ROCK활성여SLEDAI-2K평분정상관성。결론 ROCK활성여SLE질병활동도상관，가작위일충신적잠재적SLE질병활동도평고지표。
Objective To investigate the correlation between Rho kinase(ROCK) activity and systemic Lupus erythematosus(SLE) disease activity. Method ROCK activity of SLE patients and healthy volunteers was test by Western blotting. SLE disease activity was evaluated by SLEDAI-2K score. The correlation between ROCK activity and SLE disease activity was analyzed via SPSS17.0 software. Result ROCK activities of the mild, moderate and severe active group of SLE patients were all greater than healthy volunteers. ROCK activities of the moderate and severe active group of SLE patients were both greater than the mild active group. There was no difference in the ROCK activity between the moderate and severe active group of SLE patients. ROCK activity also correlated with SLEDAI-2K scores. Conclusion ROCK activity which correlated with SLE disease activity may be a new potential marker of SLE disease activity.