CAJ | 학술논문

目的：：观察慢性应激抑郁模型大鼠经不同频率的重复经颅磁刺激(rTMS)干预后行为学的变化。方法：40只成年雄性 SD 大鼠分为正常对照组(n =8)和造模组(n =32)。造模组大鼠采用孤养联合慢性不可预见性温和应激方法制备抑郁模型后分为4组：模型组(n =8,不给予任何处理)、高频组(n =8,给予10 Hz 的 rTMS 干预)、低频组(n =8,给予1 Hz 的 rTMS 干预)和伪刺激组(n =8,模拟 rTMS 环境但不发出 rTMS 刺激)。在 rTMS 干预结束后进行行为学评估,包括测量体重、蔗糖水消耗实验以及旷场实验。结果：5组大鼠的体重减分率、蔗糖水消耗量、旷场实验的水平运动评分以及垂直运动评分差异均有统计学意义(F =4.091、7.670、11.008和30.316,P <0.05)；与模型组和伪刺激组相比,高频组和低频组大鼠体重减分率、蔗糖水消耗量、旷场实验的水平运动评分以及垂直运动评分均升高(P <0.05),且高频组与低频组相比,差异均无统计学意义(P >0.05)。结论：rTMS 干预可以改善慢性应激抑郁模型大鼠的抑郁样行为；高频 rTMS 和低频 rTMS 对大鼠抑郁行为的改善作用基本相同。
목적：：관찰만성응격억욱모형대서경불동빈솔적중복경로자자격(rTMS)간예후행위학적변화。방법：40지성년웅성 SD 대서분위정상대조조(n =8)화조모조(n =32)。조모조대서채용고양연합만성불가예견성온화응격방법제비억욱모형후분위4조：모형조(n =8,불급여임하처리)、고빈조(n =8,급여10 Hz 적 rTMS 간예)、저빈조(n =8,급여1 Hz 적 rTMS 간예)화위자격조(n =8,모의 rTMS 배경단불발출 rTMS 자격)。재 rTMS 간예결속후진행행위학평고,포괄측량체중、자당수소모실험이급광장실험。결과：5조대서적체중감분솔、자당수소모량、광장실험적수평운동평분이급수직운동평분차이균유통계학의의(F =4.091、7.670、11.008화30.316,P <0.05)；여모형조화위자격조상비,고빈조화저빈조대서체중감분솔、자당수소모량、광장실험적수평운동평분이급수직운동평분균승고(P <0.05),차고빈조여저빈조상비,차이균무통계학의의(P >0.05)。결론：rTMS 간예가이개선만성응격억욱모형대서적억욱양행위；고빈 rTMS 화저빈 rTMS 대대서억욱행위적개선작용기본상동。
Aim: To explore the behavioral changes of chronic stress depression model rats given different frequency repetitive transcranial magnetic stimulation(rTMS) intervention. Methods: Forty adult male SD rats were allocated into normal control group(n = 8) and model preparation group(n = 32) randomly after screening. The rats in model preparation group were singly housed and given chronic unpredictable mild stress(CUMS) to build depression model. The rats in model preparation group were then allocated into 4 groups: model group(n = 8,without giving any treatment), high frequency group(n = 8,with the intervention of 10 Hz rTMS), low frequency group(n = 8,with the intervention of 1 Hz rTMS) and sham group(n = 8,simulation of rTMS environment without rTMS stimulus). The changes of behaviors in each group were detected by weight measurement, sucrose consumption test and open-field test. Results: There were significant differences in the weight reduction rate, sucrose consumption and the score of open field test among the 5 groups(F = 4. 091,7. 670, 11. 008, and 30. 316,P < 0. 05);compared with model group and sham group, the weight reduction rate, sucrose consump-tion and the score of open field test in high frequency group and low frequency group were higher(P < 0. 05),and the differ-ence between high frequency group and low frequency group was not significant(P > 0. 05). Conclusion: rTMS could im-prove the depression-like behavior in chronic stress depression model rats, and the improvement is basically identical be-tween high frequency rTMS stimulation and low frequency rTMS stimulation.