CAJ | 학술논문

目的：分析我国维吾尔族人群早期糖尿病肾病患者的肾脏存活及危险因素。方法回顾性分析2009年4月至2014年7月期间在新疆维吾尔自治区人民医院诊断为早期糖尿病肾病维吾尔族患者的临床特点，并与同期汉族患者比较，利用Kaplan-Meier法计算患者的累计生存率，利用COX回归模型分析相关危险因素。结果本研究共纳入83例，维吾尔族36例，平均年龄53.1±7.19岁，糖尿病病程53.61±25.60月，出现终末期肾脏病的中位时间是39月，糖尿病病程维吾尔族较同期汉族患者短，BMI大，总胆固醇、甘油三脂水平高，高尿酸血症发生比例较汉族高。COX多因素分析表明性别(男)是维吾尔族III期糖尿病肾病肾脏存活的保护因素，而平均动脉压、BMI、糖化血红蛋白、甘油三酯是维吾尔族III期糖尿病肾病患者进展至终末期肾脏病的危险因素。肾脏中位存活时间30月，较同期汉族患者低。结论维吾尔族早期糖尿病肾病患者在出现微量白蛋白尿后约3-5年可能进入ESRD，平均动脉压、BMI、糖化血红蛋白、甘油三脂是影响其预后的独立危险因素，对患者应加强防控和干预以提高患者的生存率和生存质量。
목적：분석아국유오이족인군조기당뇨병신병환자적신장존활급위험인소。방법회고성분석2009년4월지2014년7월기간재신강유오이자치구인민의원진단위조기당뇨병신병유오이족환자적림상특점，병여동기한족환자비교，이용Kaplan-Meier법계산환자적루계생존솔，이용COX회귀모형분석상관위험인소。결과본연구공납입83례，유오이족36례，평균년령53.1±7.19세，당뇨병병정53.61±25.60월，출현종말기신장병적중위시간시39월，당뇨병병정유오이족교동기한족환자단，BMI대，총담고순、감유삼지수평고，고뇨산혈증발생비례교한족고。COX다인소분석표명성별(남)시유오이족III기당뇨병신병신장존활적보호인소，이평균동맥압、BMI、당화혈홍단백、감유삼지시유오이족III기당뇨병신병환자진전지종말기신장병적위험인소。신장중위존활시간30월，교동기한족환자저。결론유오이족조기당뇨병신병환자재출현미량백단백뇨후약3-5년가능진입ESRD，평균동맥압、BMI、당화혈홍단백、감유삼지시영향기예후적독립위험인소，대환자응가강방공화간예이제고환자적생존솔화생존질량。
Objective To analyze the Uyghur people early renal survival in patients with diabetic nephropathy and risk factors. Methods The retrospective analysis in April 2009 to July 2014 in the xinjiang Uyghur autonomous region people's hospital diagnosed with clinical characteristics of patients with early diabetic nephropathy Uyghur, and compared with the han nationality patients were compared, using Kaplan Meier method to calculate the cumulative survival rate, using COX regression model analysis related risk factors. Results 83 cases were included in this study, the Uyghur 36 cases, mean age 53.1+/-7.19 years of age, 53.61+/-53.61 months duration of diabetes, end-stage renal disease in time is 39 months, Uyghur than the same period the han nationality patients with short duration of diabetes, BMI, high levels of total cholesterol, triglycerides, high uric acid hematic disease high percentage in the han nationality. COX multi-factor analysis showed that sex (male) is Uyghur phase III diabetic nephropathy kidney protection factor of survival, and mean arterial pressure, BMI, glycated hemoglobin, triglycerides are Uyghur phase III of diabetic nephropathy patients progress to end-stage kidney disease risk factors. Kidney the median survival time of 30 months, lower than the same period the han nationality patients. Conclusion The Uyghur in early diabetic nephropathy patients about 3 to 5 years after microalbuminuria may enter the ESRD, mean arterial pressure, BMI, glycated hemoglobin, triglycerides are independent risk factors affecting prognosis, should strengthen the control and prevention and intervention on the patients to improve survival and quality of life.