新疆医学
新疆醫學
신강의학
XINJIANG MEDICAL JOURNAL
2015年
7期
855-857,854
,共4页
人乳头瘤病毒%薄层液基细胞学检测%宫颈上皮内瘤变%宫颈癌
人乳頭瘤病毒%薄層液基細胞學檢測%宮頸上皮內瘤變%宮頸癌
인유두류병독%박층액기세포학검측%궁경상피내류변%궁경암
Human Rapillomavirus%Thin-layer Liquid-based%Cytology Cervical Intraepithelial Neoplasia Cervical%Cancer
目的：了解社区育龄妇女人乳头瘤病毒（HPV）感染的现状，探讨HPV基因分型检测和薄层液基细胞学（TCT）检测对社区妇女宫颈癌及癌前病变筛查的意义。方法对社区2024例已婚育龄妇女进行HPV基因分型检测和TCT检测，对检测结果异常的部分女性进行阴道镜检查，对病变部位进行活检取材行病理学检查。结果2024例女性中HPV分型检测阳性者216例，检出率10.67%，其中高危型197例，占91.2%，低危型19例，占8.8%，高危型中16型和52型检出率最高；TCT检测阳性数121例，阳性率6.0%；HPV阳性的女性中阴道镜及活检阳性率为45.45%, TCT阳性者中活检阳性率46.91%, HPV/TCT并联试验阳性者中活检阳性率42.31%；CIN各分级中TCT阳性率均为100%、HPV的阳性率除CINⅠ外也均为100%。结论本社区育龄妇女HPV感染率较高，HPV基因分型检测和（或）TCT检测可早期筛查社区妇女宫颈癌和上皮内瘤变。
目的：瞭解社區育齡婦女人乳頭瘤病毒（HPV）感染的現狀，探討HPV基因分型檢測和薄層液基細胞學（TCT）檢測對社區婦女宮頸癌及癌前病變篩查的意義。方法對社區2024例已婚育齡婦女進行HPV基因分型檢測和TCT檢測，對檢測結果異常的部分女性進行陰道鏡檢查，對病變部位進行活檢取材行病理學檢查。結果2024例女性中HPV分型檢測暘性者216例，檢齣率10.67%，其中高危型197例，佔91.2%，低危型19例，佔8.8%，高危型中16型和52型檢齣率最高；TCT檢測暘性數121例，暘性率6.0%；HPV暘性的女性中陰道鏡及活檢暘性率為45.45%, TCT暘性者中活檢暘性率46.91%, HPV/TCT併聯試驗暘性者中活檢暘性率42.31%；CIN各分級中TCT暘性率均為100%、HPV的暘性率除CINⅠ外也均為100%。結論本社區育齡婦女HPV感染率較高，HPV基因分型檢測和（或）TCT檢測可早期篩查社區婦女宮頸癌和上皮內瘤變。
목적：료해사구육령부녀인유두류병독（HPV）감염적현상，탐토HPV기인분형검측화박층액기세포학（TCT）검측대사구부녀궁경암급암전병변사사적의의。방법대사구2024례이혼육령부녀진행HPV기인분형검측화TCT검측，대검측결과이상적부분녀성진행음도경검사，대병변부위진행활검취재행병이학검사。결과2024례녀성중HPV분형검측양성자216례，검출솔10.67%，기중고위형197례，점91.2%，저위형19례，점8.8%，고위형중16형화52형검출솔최고；TCT검측양성수121례，양성솔6.0%；HPV양성적녀성중음도경급활검양성솔위45.45%, TCT양성자중활검양성솔46.91%, HPV/TCT병련시험양성자중활검양성솔42.31%；CIN각분급중TCT양성솔균위100%、HPV적양성솔제CINⅠ외야균위100%。결론본사구육령부녀HPV감염솔교고，HPV기인분형검측화（혹）TCT검측가조기사사사구부녀궁경암화상피내류변。
Objective To understand the infection status of human papilloma virus (HPV) in child-bearing age women of community, and to investigate the clinical application of HPV genotyping and thin-layer liquid-based cytology (TCT) for screening of cervical cancer and precancerous lesions of women in the community. Methods HPV genotyping and TCT detection were performed in 2024 married women of child-bearing age in the community, and the cases with abnormal TCT or positive HPV received biopsy and pathological examination under colposcope. Results Among 2024 cases, 216 cases were found with positive HPV, the detection rate was 10.67%. Among which 197 cases were infected by high risk type, accounting for 91.2%, 19 cases were infected by low risk type, accounting for 8.8%. The detection rates of type 16 and type 52 were the highest in high risk type. 121 cases were TCT positive, the positive rate was 6%. The positive rate of biopsy under colposcope was 45.45%in HPV positive women and 46.91%in TCT positive women, While, in cases with positive HPV/TCT parallel test it was 42.31%. The positive rate of TCT in different CIN grades were all 100%, and the positive rate of HPV also was 100%except CIN I. Conclusion The HPV infection rate of child-bearing age women in our community is high. Detection of HPV genotyping and (or) TCT can help us to find cervical cancer and epithelial neoplasia in the community in early stage.
