材料导报
材料導報
재료도보
MATERIALS REVIEW
2015年
13期
89-92,111
,共5页
聚乙烯亚胺%药物负载%肿瘤治疗%联合载药
聚乙烯亞胺%藥物負載%腫瘤治療%聯閤載藥
취을희아알%약물부재%종류치료%연합재약
polyethyleneimine%drug carrying%cancer therapy%drug combination
聚乙烯亚胺(PEI)作为一种阳离子聚合物在药物负载中受到了广泛的关注。PEI 具有载药高效、易于修饰粒子和生物相容性好等特点,成为了研究热点。综述了目前 PEI 的研究现状,介绍了 PEI 修饰磁性纳米颗粒的制备方法,并对其载药治疗癌症的相关进展进行了讨论,重点阐述了 PEI 在联合载药抗肿瘤方面的应用,最后指出了PEI 在肿瘤治疗过程中仍需解决的问题和未来发展趋势。
聚乙烯亞胺(PEI)作為一種暘離子聚閤物在藥物負載中受到瞭廣汎的關註。PEI 具有載藥高效、易于脩飾粒子和生物相容性好等特點,成為瞭研究熱點。綜述瞭目前 PEI 的研究現狀,介紹瞭 PEI 脩飾磁性納米顆粒的製備方法,併對其載藥治療癌癥的相關進展進行瞭討論,重點闡述瞭 PEI 在聯閤載藥抗腫瘤方麵的應用,最後指齣瞭PEI 在腫瘤治療過程中仍需解決的問題和未來髮展趨勢。
취을희아알(PEI)작위일충양리자취합물재약물부재중수도료엄범적관주。PEI 구유재약고효、역우수식입자화생물상용성호등특점,성위료연구열점。종술료목전 PEI 적연구현상,개소료 PEI 수식자성납미과립적제비방법,병대기재약치료암증적상관진전진행료토론,중점천술료 PEI 재연합재약항종류방면적응용,최후지출료PEI 재종류치료과정중잉수해결적문제화미래발전추세。
As a kind of cationic polymer,polyethyleneimine (PEI)has received remarkable attentions and in-tense researches upon its use in drug carrying due to its excellent properties such as efficient drug loading,ease of modifying particles and good biocompatibility.Herein the research status about PEI and its use in modifying magnetic nanoparticles is reviewed,focusing on the relevant developments about using PEI-modified Fe3 O4 particles in drug loading and drug combinations with application to cancer therapy.Finally the potential issues and prospective trends of PEI in cancer therapy are proposed.