CAJ | 학술논문

目的：探讨慢性乙型肝炎患者 HBV YMDD变异的情况、相关影响因素及临床意义，为临床诊断和治疗提供依据。方法对100例慢性乙型肝炎患者采用实时荧光PCR法检测血清中HBVYMDD变异及HBVDNA载量。结果100例乙肝患者中检出HBV YMDD变异共13例（阳性率13％），其中YIDD变异7例，YVDD变异5例，YIDD／YVDD共生变异1例。13例YMDD变异患者 HBV DNA在（1．77×105～1×108） IU／mL ，丙氨酸转氨酶（ALT ）水平18．1～273．5 U／L。结论未发现慢性乙型肝炎患者的性别、年龄、乙型肝炎E抗原（HBeAg）状态、HBV DNA载量及ALT水平与 HBV YMDD变异检出率之间存在相关性，差异无统计学意义（P＞0．05）。
목적：탐토만성을형간염환자 HBV YMDD변이적정황、상관영향인소급림상의의，위림상진단화치료제공의거。방법대100례만성을형간염환자채용실시형광PCR법검측혈청중HBVYMDD변이급HBVDNA재량。결과100례을간환자중검출HBV YMDD변이공13례（양성솔13％），기중YIDD변이7례，YVDD변이5례，YIDD／YVDD공생변이1례。13례YMDD변이환자 HBV DNA재（1．77×105～1×108） IU／mL ，병안산전안매（ALT ）수평18．1～273．5 U／L。결론미발현만성을형간염환자적성별、년령、을형간염E항원（HBeAg）상태、HBV DNA재량급ALT수평여 HBV YMDD변이검출솔지간존재상관성，차이무통계학의의（P＞0．05）。
Objective To discuss YMDD mutation ,related factors and clinical significance in chronic hepatitis B patients ,provi‐ding the basis for clinical diagnosis and treatment .Methods YMDD mutations and DNA load of hepatitis B virus in 100 chronic hepatitis B patients were detected by real‐time fluorescence PCR .Results YMDD mutations of hepatitis B virus were found in 13 out of 100 patients(positive rate 13% ) .Including YIDD mutations in 7 ,YVDD mutations in 5 and YIDD/YVDD symbiotic mutation in 1 .In the 13 patients ,HBV DNA load and ALT level were at (1 .77 × 105 -1 × 108 )IU/mL and 18 .1-273 .5 U/L .Conclusion Do not find the detection rate of YMDD mutation in chronic hepatitis B patients is related with gender ,age ,HBeAg status ,HBV DNA load and ALT level ,the difference has no statistical significance (P>0 .05) .