国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
15期
2177-2179,2182
,共4页
李晶晶%阚丽娟%张秀明%温冬梅%孙各琴%索明环%张德才
李晶晶%闞麗娟%張秀明%溫鼕梅%孫各琴%索明環%張德纔
리정정%감려연%장수명%온동매%손각금%색명배%장덕재
葡萄糖-6-磷酸脱氢酶%缺乏%糖化血红蛋白
葡萄糖-6-燐痠脫氫酶%缺乏%糖化血紅蛋白
포도당-6-린산탈경매%결핍%당화혈홍단백
glucose-6-phosphate dehydrogenase%deficiency%hemoglobin A1c
目的：通过对4组不同人群的葡萄糖‐6‐磷酸脱氢酶（G6PD）活性和糖化血红蛋白（HbA1c）测定结果进行统计分析，探讨G6PD缺乏与 HbA1c的关系。方法选取2012年8月至2014年10月期间来该院进行健康体检者171例作为对照组；同时期该院确诊且符合WHO诊断标准的2型糖尿病患者195例（合并G6PD缺乏者7例）及G6PD缺乏患者73例（合并2型糖尿病者9例），分别设为糖尿病组188例，单纯G6PD缺乏组64例，糖尿病伴G6PD缺乏组16例。分别测定 HbA1c、G6PD活性、空腹血糖（FBG）、间接胆红素（IBIL）、红细胞计数（RBC）、血红蛋白（HGB）水平并进行统计分析。结果与对照组相比，单纯G6PD缺乏组HbA1c值、RBC、HGB结果均偏低，差异具有统计学意义（P＜0．05）；与糖尿病组相比，糖尿病伴G6PD缺乏组HbA1c值、RBC、HGB结果均偏低，IBIL 结果偏高，差异均具有统计学意义（P＜0．05）。对照组及糖尿病伴 G6PD缺乏组 G6PD活性与HbA1c水平不具有相关性，糖尿病组G6PD活性与其 HbA1c水平呈负相关（r＝－0．161，P＝0．033），单纯G6PD缺乏组G6PD活性与其HbA1c水平呈正相关（r＝0．324，P＝0．005）；单纯G6PD缺乏组HbA1c水平与FBG无相关性，糖尿病伴G6PD缺乏组的HbA1c水平与 FBG 呈正相关但其 HbA1c水平与真实 HbA1c水平及相应的 FBG 水平不相符。结论 G6PD 缺乏导致HbA1c测定结果假性偏低，造成HbA1c水平与真实 FBG水平不符。单纯G6PD缺乏者的 HbA1c水平随G6PD活性增高而增高，糖尿病组HbA1c水平随G6PD活性降低而增高。
目的：通過對4組不同人群的葡萄糖‐6‐燐痠脫氫酶（G6PD）活性和糖化血紅蛋白（HbA1c）測定結果進行統計分析，探討G6PD缺乏與 HbA1c的關繫。方法選取2012年8月至2014年10月期間來該院進行健康體檢者171例作為對照組；同時期該院確診且符閤WHO診斷標準的2型糖尿病患者195例（閤併G6PD缺乏者7例）及G6PD缺乏患者73例（閤併2型糖尿病者9例），分彆設為糖尿病組188例，單純G6PD缺乏組64例，糖尿病伴G6PD缺乏組16例。分彆測定 HbA1c、G6PD活性、空腹血糖（FBG）、間接膽紅素（IBIL）、紅細胞計數（RBC）、血紅蛋白（HGB）水平併進行統計分析。結果與對照組相比，單純G6PD缺乏組HbA1c值、RBC、HGB結果均偏低，差異具有統計學意義（P＜0．05）；與糖尿病組相比，糖尿病伴G6PD缺乏組HbA1c值、RBC、HGB結果均偏低，IBIL 結果偏高，差異均具有統計學意義（P＜0．05）。對照組及糖尿病伴 G6PD缺乏組 G6PD活性與HbA1c水平不具有相關性，糖尿病組G6PD活性與其 HbA1c水平呈負相關（r＝－0．161，P＝0．033），單純G6PD缺乏組G6PD活性與其HbA1c水平呈正相關（r＝0．324，P＝0．005）；單純G6PD缺乏組HbA1c水平與FBG無相關性，糖尿病伴G6PD缺乏組的HbA1c水平與 FBG 呈正相關但其 HbA1c水平與真實 HbA1c水平及相應的 FBG 水平不相符。結論 G6PD 缺乏導緻HbA1c測定結果假性偏低，造成HbA1c水平與真實 FBG水平不符。單純G6PD缺乏者的 HbA1c水平隨G6PD活性增高而增高，糖尿病組HbA1c水平隨G6PD活性降低而增高。
목적：통과대4조불동인군적포도당‐6‐린산탈경매（G6PD）활성화당화혈홍단백（HbA1c）측정결과진행통계분석，탐토G6PD결핍여 HbA1c적관계。방법선취2012년8월지2014년10월기간래해원진행건강체검자171례작위대조조；동시기해원학진차부합WHO진단표준적2형당뇨병환자195례（합병G6PD결핍자7례）급G6PD결핍환자73례（합병2형당뇨병자9례），분별설위당뇨병조188례，단순G6PD결핍조64례，당뇨병반G6PD결핍조16례。분별측정 HbA1c、G6PD활성、공복혈당（FBG）、간접담홍소（IBIL）、홍세포계수（RBC）、혈홍단백（HGB）수평병진행통계분석。결과여대조조상비，단순G6PD결핍조HbA1c치、RBC、HGB결과균편저，차이구유통계학의의（P＜0．05）；여당뇨병조상비，당뇨병반G6PD결핍조HbA1c치、RBC、HGB결과균편저，IBIL 결과편고，차이균구유통계학의의（P＜0．05）。대조조급당뇨병반 G6PD결핍조 G6PD활성여HbA1c수평불구유상관성，당뇨병조G6PD활성여기 HbA1c수평정부상관（r＝－0．161，P＝0．033），단순G6PD결핍조G6PD활성여기HbA1c수평정정상관（r＝0．324，P＝0．005）；단순G6PD결핍조HbA1c수평여FBG무상관성，당뇨병반G6PD결핍조적HbA1c수평여 FBG 정정상관단기 HbA1c수평여진실 HbA1c수평급상응적 FBG 수평불상부。결론 G6PD 결핍도치HbA1c측정결과가성편저，조성HbA1c수평여진실 FBG수평불부。단순G6PD결핍자적 HbA1c수평수G6PD활성증고이증고，당뇨병조HbA1c수평수G6PD활성강저이증고。
Objective To discuss the relationship between G6PD deficient and HbA1c ,we statistical and analysis the G6PD ac‐tivity and HbA1c measured results between four groups .Methods Chosen 171 cases of healthy controls in our hospital from Au‐gust 2012 to October 2012 as normal control group .195 cases patients who diagnosised as type 2 diabetes(7 cases combined with G6PD deficient) and 73 patients with G6PD deficient(9 cases combined with type 2 diabetes) were divided into three groups :188 cases of diabetes group ,64 cases G6PD deficient group ,16 cases of diabetes combined with G6PD deficient group .Determination and statistical analysis their HbA1c ,G6PD activity ,fasting blood glucose(FBG) ,indirect bilirubin(IBIL) ,red blood cell count(RBC) , hemoglobin(HGB) content .Results Compared with normal control group ,the results of HbA1c values ,RBC ,HGB were low in G6PD deficient group ,the differences were significant (P< 0 .05);Compared with diabetes group ,the results of HbA1c values , RBC ,HGB are low in diabetes combined with G6PD deficient group ,however the IBIL result was high ,the differences were signifi‐cant(P<0 .05) .Normal control group′s and diabetes combined with G6PD deficient group′s G6PD activity and HbA1c level was not relevant .G6PD activity and HbA1c level in diabetes group has a significant negative correlation (r= -0 .161 ,P=0 .033) ,G6PD activity and HbA1c level in G6PD deficiency group had a significant positive correlation (r= 0 .324 ,P= 0 .005);G6PD deficient group′s HbA1c level and FBG had no relevance ;HbA1c levels and FBG had a significant positive correlation in the diabetes group who with G6PD deficiency ,however ,the HbA1c levels didn′t matched the real HbA1c levels and the corresponding FBG levels . Conclusion G6PD deficiency caused HbA1c determination result false low ,which leads HbA1c level don′t matched the real HbA1c level and the corresponding FBG level .G6PD deficient group′s HbA1c level increased with G6PD activity′s increase .Diabetes com‐bined with G6PD deficient group′s HbA1c level has no relevance with G6PD activity .Diabetes group′s HbA1c level increased with G6PD activity′s decrease .
