CAJ | 학술논문

目的：探究系统性红斑狼疮患者疾病活动度与血清铁蛋白（FET ）的关系。方法选取2013年3月至2014年3月于惠东县妇幼保健院进行治疗的系统性红斑狼疮（SLE）患者40例，按疾病的活动度分为稳定期组和活动期组，各20例，同时选取健康志愿者20例纳入对照组。比较3组受试者FET、抗双链DNA（ds‐DNA）抗体水平及SLE疾病活动度指标（SLEDAI）评分。结果稳定期组和活动期组FET、ds‐DNA抗体水平明显高于对照组，活动期组FET、ds‐DNA抗体水平及SLEDAI评分明显高于稳定期组，差异均有统计学意义（P＜0．05）。稳定期组与活动期组患者FET异常率分别为40％、90％，差异有统计学意义（P＜0．05）。SLE患者FET水平与ds‐DNA抗体、SLEDAI评分均呈正相关（r分别为0．541、0．620，P＜0．05）。治疗后2组患者FET升高例数较治疗前均下降，FET水平均降低，治疗前后差异均有统计学意义（P＜0．05）。结论 FET 水平与SLE患者疾病活动度呈正相关，可以将其作为诊断SLE的可靠指标。
목적：탐구계통성홍반랑창환자질병활동도여혈청철단백（FET ）적관계。방법선취2013년3월지2014년3월우혜동현부유보건원진행치료적계통성홍반랑창（SLE）환자40례，안질병적활동도분위은정기조화활동기조，각20례，동시선취건강지원자20례납입대조조。비교3조수시자FET、항쌍련DNA（ds‐DNA）항체수평급SLE질병활동도지표（SLEDAI）평분。결과은정기조화활동기조FET、ds‐DNA항체수평명현고우대조조，활동기조FET、ds‐DNA항체수평급SLEDAI평분명현고우은정기조，차이균유통계학의의（P＜0．05）。은정기조여활동기조환자FET이상솔분별위40％、90％，차이유통계학의의（P＜0．05）。SLE환자FET수평여ds‐DNA항체、SLEDAI평분균정정상관（r분별위0．541、0．620，P＜0．05）。치료후2조환자FET승고례수교치료전균하강，FET수평균강저，치료전후차이균유통계학의의（P＜0．05）。결론 FET 수평여SLE환자질병활동도정정상관，가이장기작위진단SLE적가고지표。
Objective To explore the relationship between the disease activity of patients with systemic lupus erythematosus (SLE)and serum ferritin(FET ) .Methods A total of 40 patients with SLE from March 2013 to March 2014 in Huidong County Maternal and Child Health Care Hospital were selected into this study and divided into plateau group and activity group according to disease activity ,20 patients in each group .Other 20 healthy volunteers were selected as the control group .The FET ,anti‐double‐stranded dna(ds‐DNA) antibody and SLE disease activity index (SLEDAI) score were compared in the three groups .Results The FET ,ds‐DNA antibody levels in plateau group and activity group were statistical significant higher than the control group (P<0 .05) .The FET ,ds‐DNA antibody levels and SLEDAI score in the activity group were significant higher than that of the plateau group(P< 0 .05) .The abnormal rate of plateau group and activity group were 40% ,90% respectively ,the difference was statistical significant(P< 0 .05) .The FET level of SLE patients was positive correlated with ds‐DNA antibody ,the SLEDAI score(r=0 .541 , r=0 .541 ,P<0 .05) .The number of patients with FET levels rising in the plateau group and activity group after treatment were decreased ,and the levels of FET were decreased ,the differences were significant(P<0 .05) .Conclusion FET levels and disease ac‐tivity in patients with SLE are positively correlated ,it could be used as laboratory index of diagnosis for SLE .