CAJ | 학술논문

目的：回顾性分析该院金黄色葡萄球菌在临床感染的分布调查，对其耐药性变迁情况进行调查研究，为临床抗感染治疗提供依据。方法对2012年1～12月该院送检的13175例标本中分离出406株金黄色葡萄球菌进行临床感染分布及药敏试验结果进行统计对比分析；分离菌株用VIT EK 2 Compact型全自动微生物鉴定及药敏系统进行鉴定，用珠海美华医疗科技有限公司生产的葡萄球菌鉴定及药敏分析系统测试板进行药敏试验。结果金黄色葡萄球菌在科室感染分布中分离率最高的是儿科和神经外科。在临床各类标本中分离率最高的标本是痰液和脓液。金黄色葡萄球菌耐药率最低的是达托霉素和万古霉素耐药率为0％，耐甲氧西林金黄色葡萄球菌（M RS A ）菌株的耐药性明显高于非M RS A菌株的耐药性。金黄色葡萄球菌对万古霉素敏感性减低筛查显示耐药率存在上升趋势；结论三亚地区金黄色葡萄球菌对达托霉素和万古霉素保持较好的敏感性，仍可作为临床抗感染的治疗首选药物。应加强金黄色葡萄球菌耐药基因的检测，可避免多药耐药菌株在院内感染的流行，可指导临床选择用药。
목적：회고성분석해원금황색포도구균재림상감염적분포조사，대기내약성변천정황진행조사연구，위림상항감염치료제공의거。방법대2012년1～12월해원송검적13175례표본중분리출406주금황색포도구균진행림상감염분포급약민시험결과진행통계대비분석；분리균주용VIT EK 2 Compact형전자동미생물감정급약민계통진행감정，용주해미화의료과기유한공사생산적포도구균감정급약민분석계통측시판진행약민시험。결과금황색포도구균재과실감염분포중분리솔최고적시인과화신경외과。재림상각류표본중분리솔최고적표본시담액화농액。금황색포도구균내약솔최저적시체탁매소화만고매소내약솔위0％，내갑양서림금황색포도구균（M RS A ）균주적내약성명현고우비M RS A균주적내약성。금황색포도구균대만고매소민감성감저사사현시내약솔존재상승추세；결론삼아지구금황색포도구균대체탁매소화만고매소보지교호적민감성，잉가작위림상항감염적치료수선약물。응가강금황색포도구균내약기인적검측，가피면다약내약균주재원내감염적류행，가지도림상선택용약。
Objective To retrospective analysis the distribution of Staphylococcus aureus infection ,and to study their drug re‐sistance change ,then to provide the basis for clinical anti‐infection treatment .Methods The clinical infection distribution and drug susceptibility test results was tested in 406 strains of Staphylococcus aureus which were isolated from the specimens of 13175 cases from January 2012 to December 2012 ,then analysis these results using statistical methods ;Isolated strains were identified by VITEK 2 Compact type automatic microbial identification and drug susceptibility system ,accompanied with drug sensitive test using Staphylococcus aureus identification and drug susceptibility analysis system test plate of Zhuhai Meihua Medical Technology com‐pany .Results The highest separation rates of Staphylococcus aureus in all clinical departments infection distribution were in de‐partment of pediatrics and neurosurgery .The highest separation rates of all kinds of clinical specimen were sputum and pus .For Staphylococcus aureus ,the lowest resistant rates were in daptomycin and vancomycin ,whose rates were both zero ;the drug resist‐ance of MRSA strains was obviously higher than that of the drug resistance of non‐MRSA strains .The reduced susceptibility to vancomycin in Staphylococcus aureus in screening showed that the drug resistance rate was rising .Conclusion Staphylococcus au‐reus in Sanya kept a good sensitivity of daptomycin and vancomycin ,these two drugs can still be the first choice drug for clinical an‐ti‐infection treatment .