CAJ | 학술논문

目的：探讨氨基末端B型钠尿肽原（NT‐proBNP）和心肌肌钙蛋白I（cTnI）联合检测在心力衰竭（HF）患者诊治中的临床价值。方法选择心血管患者198例作为研究对象，其中H F患者95例作为H F组，非H F患者103例作为对照组，比较两组患者左心室射血分数（LVEF）及血清NT‐proBNP、cTnI水平，并比较HF组不同心功能患者LVEF、血清NT‐proBNP、cTnI水平，分析HF患者血清NT‐proBNP、cTnI水平与 LVEF的相关性。NT‐proBNP、cTnI联合检测和单项检测对 HF的诊断价值。结果 HF组LVEF及血清NT‐proBNP、cTnI水平均高于对照组（P＜0．05），HF组患者随着心功能分级的增加，LVEF明显下降，血清NT‐proBNP、cTnI水平明显升高，差异有统计学意义（P＜0．05），血清 NT‐proBNP、cTnI水平与LVEF呈负相关（r＝－0．536、－0．328，P＜0．05）；proBNP、cTnI联合检测诊断 HF的特异度、阳性预测值及准确率较单项检测明显提高，其中特异度、准确率与cTnI比较，差异有统计学意义（χ2＝4．595、21．648，P＝0．032、0．000）。结论血清 NT‐proBNP、cTnI水平检测对于HF的诊断及病情判断有重要的临床价值。
목적：탐토안기말단B형납뇨태원（NT‐proBNP）화심기기개단백I（cTnI）연합검측재심력쇠갈（HF）환자진치중적림상개치。방법선택심혈관환자198례작위연구대상，기중H F환자95례작위H F조，비H F환자103례작위대조조，비교량조환자좌심실사혈분수（LVEF）급혈청NT‐proBNP、cTnI수평，병비교HF조불동심공능환자LVEF、혈청NT‐proBNP、cTnI수평，분석HF환자혈청NT‐proBNP、cTnI수평여 LVEF적상관성。NT‐proBNP、cTnI연합검측화단항검측대 HF적진단개치。결과 HF조LVEF급혈청NT‐proBNP、cTnI수평균고우대조조（P＜0．05），HF조환자수착심공능분급적증가，LVEF명현하강，혈청NT‐proBNP、cTnI수평명현승고，차이유통계학의의（P＜0．05），혈청 NT‐proBNP、cTnI수평여LVEF정부상관（r＝－0．536、－0．328，P＜0．05）；proBNP、cTnI연합검측진단 HF적특이도、양성예측치급준학솔교단항검측명현제고，기중특이도、준학솔여cTnI비교，차이유통계학의의（χ2＝4．595、21．648，P＝0．032、0．000）。결론혈청 NT‐proBNP、cTnI수평검측대우HF적진단급병정판단유중요적림상개치。
Objective To investigate the clinical value of NT‐proBNP and cTnI detection in the diagnosis and treatment of con‐gestiveheartfailure.Methods 198patientswithcardiovascularwereastheresearchobjects,95caseswithHFwereasHFgroup, 103 caseswithout HF were as control group ,compared left ventricular ejection fraction (LVEF) and serum NT‐proBNP ,cTnI levels of patients ,and compared LVEF ,serum NT‐proBNP ,cTnI levels of patients with different cardiac functions ,analysed the correla‐tion between serum NT‐proBNP ,cTnI levels and LVEF in patients with HF ,and analysed the diagnosic value of NT‐proBNP ,cTnI combined detection and single detection on HF .Results LVEF and serum NT‐proBNP ,cTnI levels of the HF group were higher than those of the control group(P<0 .05) ,LVEF of the HFgroup decreased significantly when cardiac function classification in‐creased ,serum NT‐proBNP ,cTnI levels increased significantly ,there were statistically significant differences in the indices between the three groups(P<0 .05) ,serum NT‐proBNP ,cTnI was inversely related to the level of LVEF (r= -0 .536 ,-0 .328 ,P<0 .05);proBNP ,the specificity ,positive predictive value and accuracy in the diagnosis of HF byproBNP 、cTnI combined detection improved obviously than the single detection ,compared with cTnI the specificity ,accuracy rate ,there was difference significant(χ2 =4 .595 , 21 .648 ,P=0 .032 ,0 .000) .Conclusion It has important clinical value Serum NT‐proBNP ,cTnI levels detection for the diagnosis and judgment of HF .